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dc.contributor.authorHansen, S
dc.contributor.authorStrøm, M
dc.contributor.authorOlsen, S F
dc.contributor.authorDahl, R
dc.contributor.authorHoffmann, H J
dc.contributor.authorGranström, C
dc.contributor.authorRytter, D
dc.contributor.authorBech, B H
dc.contributor.authorLinneberg, A
dc.contributor.authorMaslova, E
dc.contributor.authorKiviranta, H
dc.contributor.authorRantakokko, P
dc.contributor.authorHalldorsson, T I
dc.date.accessioned2016-04-26T13:39:25Zen
dc.date.available2016-04-26T13:39:25Zen
dc.date.issued2016-02en
dc.date.submitted2016en
dc.identifier.citationClin. Exp. Allergy. 2016, 46 (2):329-36en
dc.identifier.issn1365-2222en
dc.identifier.pmid26333063en
dc.identifier.doi10.1111/cea.12631en
dc.identifier.urihttp://hdl.handle.net/2336/607141en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractPrenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.
dc.description.abstractIn a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).
dc.description.abstractThere were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).
dc.description.abstractOur data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.
dc.description.sponsorshipDanish Agency for Science, Technology and Innovation DSF: 09-067124 DSF: 09-063072 DFS: 2101-06-0005 FSS: 09-065631en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/ 10.1111/cea.12631en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/cea.12631/epdfen
dc.rightsArchived with thanks to Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunologyen
dc.subjectOfnæmien
dc.subjectLungnasjúkdómaren
dc.subjectFósturen
dc.subjectMeðgangaen
dc.subjectNUR12
dc.subject.meshHypersensitivityen
dc.subject.meshAir Pollutantsen
dc.subject.meshPrenatal Exposure Delayed Effectsen
dc.subject.meshMaternal Exposureen
dc.subject.meshLung Diseases, Obstructiveen
dc.titlePrenatal exposure to persistent organic pollutants and offspring allergic sensitization and lung function at 20 years of age.en
dc.typeArticleen
dc.contributor.department[ 1 ] Statens Serum Inst, Dept Epidemiol Res, Ctr Fetal Programming, Artillerivej 5, DK-2300 Copenhagen S, Denmark [ 2 ] Harvard Univ, TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA [ 3 ] Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark [ 4 ] Aarhus Univ Hosp, Dept Pulm Med & Allergy, DK-8000 Aarhus, Denmark [ 5 ] Aarhus Univ, Epidemiol Sect, Dept Publ Hlth, Aarhus, Denmark [ 6 ] Capital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark [ 7 ] Glostrup Univ Hosp, Dept Clin Expt Res, Glostrup, Denmark [ 8 ] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark [ 9 ] Natl Inst Hlth & Welf, Chem & Hlth Unit, Kuopio, Finland [ 10 ] Univ Iceland, Fac Food Sci & Nutr, Reykjavik, Iceland [ 11 ] Landspitali Univ Hosp, Unit Nutr Res, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospitalen
dc.identifier.journalClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunologyen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractPrenatal exposures to persistent organic pollutants (POPs) have been associated with asthma medication use and self-reported symptoms, but associations with lung function and allergic sensitization have been minimally explored. The aim of the study was to examine the associations between prenatal exposures to POPs and allergic sensitization and lung function in 20-year-old offspring.
html.description.abstractIn a Danish cohort of 965 pregnant women established in 1988-1989, six polychlorinated biphenyl (PCB) congeners, hexachlorobenzene (HCB), and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in gestational week 30 (n = 872). Among those with available maternal exposure information, at age 20, 421 offspring attended attended a clinical examination including measurements of allergic sensitization (serum-specific IgE ≥ 0.35 kUA /L) (n = 418) and lung function [forced expiratory volume in one second (FEV1 ) and forced vital capacity (FVC)] (n = 414).
html.description.abstractThere were no associations between maternal concentrations of POPs and offspring allergic sensitization at 20 years of age. Maternal concentrations of POPs were, however, positively associated with offspring airway obstruction (FEV1 /FVC < 75%). Compared to offspring in the first tertile of exposure, offspring in the third tertile of dioxin-like PCB exposure had an OR of 2.96 (95% CI: 1.14-7.70). Similar associations for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (1.09, 7.57), respectively. No associations were observed with reduced lung function (FEV1 % of predicted value < 90%).
html.description.abstractOur data indicate that prenatal exposure to POPs appears to be associated with airway obstruction but not allergic sensitization at 20 years of age. The findings support that chronic obstructive lung diseases may have at least part of their origins in early life.


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