Prevalence and complications of chronic kidney disease in a representative elderly population in Iceland.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Okparavero, AghoghoFoster, Meredith C
Tighiouart, Hocine
Gudnason, Vilmundur
Indridason, Olafur
Gudmundsdottir, Hrefna
Eiriksdottir, Gudny
Gudmundsson, Elias F
Inker, Lesley A
Levey, Andrew S
Issue Date
2016-03
Metadata
Show full item recordCitation
Nephrol. Dial. Transplant 2016, 31 (3):439-47Abstract
Chronic kidney disease (CKD) is common in the elderly, but data are limited on the distribution of glomerular filtration rate (GFR) and albuminuria and the prevalence of CKD and related complications in this population.A cross-sectional study of 3173 older Icelandic adults [42% men; mean (standard deviation, SD) age of 80 (5) years] was performed to examine the distribution of estimated glomerular filtration rate (eGFR) from creatinine and cystatin C, the albumin-to-creatinine ratio (ACR), and CKD-related metabolic complications (hyperparathyroidism, anemia, hypoalbuminemia, increased anion gap, acidosis, hyperphosphatemia and hyperkalemia).
There was substantial variability in eGFR [mean (SD) 64 (18) mL/min/1.73 m(2)] and ACR [median (interquartile range) 8 (5, 17) mg/g]. The prevalence (95% confidence interval) of reduced eGFR (<60 mL/min/1.73 m(2)), albuminuria (ACR >30 mg/g) and CKD (either reduced eGFR or albuminuria) was 40% (38-41), 14% (12-15) and 45% (43-47), respectively. The prevalence of complications was higher among those with versus without CKD: hyperparathyroidism (38 versus 15%), anemia (26 versus 14%), hypoalbuminemia (19 versus 13%), increased anion gap (9 versus 5%), acidosis (5 versus 1%); (P ≤ 0.02 for all), except hyperphosphatemia (1 versus 1%) and hyperkalemia (0% overall).
The burden of CKD and CKD-related complications is high among community dwelling elderly Icelandic adults. The wide range of eGFR and ACR suggests heterogeneity in processes leading to CKD and that factors beyond aging contribute to the development of CKD in the elderly.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://dx.doi.org/ 10.1093/ndt/gfv370Rights
Archived with thanks to Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Associationae974a485f413a2113503eed53cd6c53
10.1093/ndt/gfv370
Scopus Count
Collections
Related articles
- The association of chronic kidney disease complications by albuminuria and glomerular filtration rate: a cross-sectional analysis.
- Authors: Viswanathan G, Sarnak MJ, Tighiouart H, Muntner P, Inker LA
- Issue date: 2013 Jul
- Metabolic complications in elderly adults with chronic kidney disease.
- Authors: Drawz PE, Babineau DC, Rahman M
- Issue date: 2012 Feb
- The prevalence and detection of chronic kidney disease (CKD)-related metabolic complications as a function of estimated glomerular filtration rate in the oldest old.
- Authors: Van Pottelbergh G, Vaes B, Jadoul M, Matheï C, Wallemacq P, Degryse JM
- Issue date: 2012 May-Jun
- CKD and cardiovascular disease in the Atherosclerosis Risk in Communities (ARIC) study: interactions with age, sex, and race.
- Authors: Hui X, Matsushita K, Sang Y, Ballew SH, Fülöp T, Coresh J
- Issue date: 2013 Oct
- Prevalence of reduced kidney function and albuminuria in older adults: the Berlin Initiative Study.
- Authors: Ebert N, Jakob O, Gaedeke J, van der Giet M, Kuhlmann MK, Martus P, Mielke N, Schuchardt M, Tölle M, Wenning V, Schaeffner ES
- Issue date: 2017 Jun 1