• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Bordbar, Aarash
Johansson, Pär I.
Paglia, Giuseppe
Harrison, Scott J.
Wichuk, Kristine
Magnusdottir, Manuela
Valgeirsdottir, Sóley
Gybel-Brask, Mikkel
Ostrowski, Sisse R.
Palsson, Sirus
Rolfsson, Ottar
Sigurjónsson, Olafur E.
Hansen, Morten B.
Gudmundsson, Sveinn
Palsson, Bernhard O.
Show allShow less
Issue Date
2016-04

Metadata
Show full item record
Citation
Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes 2016, 56 (4):852 Transfusion
Abstract
BACKGROUNDThere has been interest in determining whether older red blood cell (RBC) units have negative clinical effects. Numerous observational studies have shown that older RBC units are an independent factor for patient mortality. However, recently published randomized clinical trials have shown no difference of clinical outcome for patients receiving old or fresh RBCs. An overlooked but essential issue in assessing RBC unit quality and ultimately designing the necessary clinical trials is a metric for what constitutes an old or fresh RBC unit. STUDY DESIGN AND METHODSTwenty RBC units were profiled using quantitative metabolomics over 42 days of storage in SAGM with 3- to 4-day time intervals. Metabolic pathway usage during storage was assessed using systems biology methods. The detected time intervals of the metabolic states were compared to clinical outcomes. RESULTSUsing multivariate statistics, we identified a nonlinear decay process exhibiting three distinct metabolic states (Days 0-10, 10-17, and 17-42). Hematologic variables traditionally measured in the transfusion setting (e.g., pH, hemolysis, RBC indices) did not distinguish these three states. Systemic changes in pathway usage occurred between the three states, with key pathways changing in both magnitude and direction. Finally, an association was found between the time periods of the metabolic states with the clinical outcomes of more than 280,000 patients in the country of Denmark transfused over the past 15 years and endothelial damage markers in healthy volunteers undergoing autologous transfusions. CONCLUSIONThe state of RBC metabolism may be a better indicator of cellular quality than traditional hematologic variables.
Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the page
Additional Links
http://doi.wiley.com/10.1111/trf.13460
http://onlinelibrary.wiley.com/doi/10.1111/trf.13460/epdf
Rights
Archived with thanks to Transfusion
ae974a485f413a2113503eed53cd6c53
10.1111/trf.13460
Scopus Count
Collections
English Journal Articles (Peer Reviewed)
English Journal Articles (Peer Reviewed)

entitlement

 

DSpace software (copyright © 2002 - 2022)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.