Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
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Authors
Mbarek, HamdiSteinberg, Stacy
Nyholt, Dale R
Gordon, Scott D
Miller, Michael B
McRae, Allan F
Hottenga, Jouke Jan
Day, Felix R
Willemsen, Gonneke
de Geus, Eco J
Davies, Gareth E
Martin, Hilary C
Penninx, Brenda W
Jansen, Rick
McAloney, Kerrie
Vink, Jacqueline M
Kaprio, Jaakko
Plomin, Robert
Spector, Tim D
Magnusson, Patrik K
Reversade, Bruno
Harris, R Alan
Aagaard, Kjersti
Kristjansson, Ragnar P
Olafsson, Isleifur
Eyjolfsson, Gudmundur Ingi
Sigurdardottir, Olof
Iacono, William G
Lambalk, Cornelis B
Montgomery, Grant W
McGue, Matt
Ong, Ken K
Perry, John R B
Martin, Nicholas G
Stefánsson, Hreinn
Stefánsson, Kari
Boomsma, Dorret I
Issue Date
2016-05-05
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Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility. 2016, 98 (5):898-908 Am. J. Hum. Genet.Abstract
Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown physiological pathways and genetic origin. DZ twinning might index increased fertility and has distinct health implications for mother and child. We performed a GWAS in 1,980 mothers of spontaneous DZ twins and 12,953 control subjects. Findings were replicated in a large Icelandic cohort and tested for association across a broad range of fertility traits in women. Two SNPs were identified (rs11031006 near FSHB, p = 1.54 × 10(-9), and rs17293443 in SMAD3, p = 1.57 × 10(-8)) and replicated (p = 3 × 10(-3) and p = 1.44 × 10(-4), respectively). Based on ∼90,000 births in Iceland, the risk of a mother delivering twins increased by 18% for each copy of allele rs11031006-G and 9% for rs17293443-C. A higher polygenic risk score (PRS) for DZ twinning, calculated based on the results of the DZ twinning GWAS, was significantly associated with DZ twinning in Iceland (p = 0.001). A higher PRS was also associated with having children (p = 0.01), greater lifetime parity (p = 0.03), and earlier age at first child (p = 0.02). Allele rs11031006-G was associated with higher serum FSH levels, earlier age at menarche, earlier age at first child, higher lifetime parity, lower PCOS risk, and earlier age at menopause. Conversely, rs17293443-C was associated with later age at last child. We identified robust genetic risk variants for DZ twinning: one near FSHB and a second within SMAD3, the product of which plays an important role in gonadal responsiveness to FSH. These loci contribute to crucial aspects of reproductive capacity and health.Description
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageAdditional Links
http://dx.doi.org/ 10.1016/j.ajhg.2016.03.008Rights
Archived with thanks to American journal of human geneticsae974a485f413a2113503eed53cd6c53
10.1016/j.ajhg.2016.03.008
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