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dc.contributor.authorMariusdottir, Elin
dc.contributor.authorIngimarsson, Johann P
dc.contributor.authorJonsson, Eirikur
dc.contributor.authorEinarsson, Gudmundur V
dc.contributor.authorAspelund, Thor
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorGudbjartsson, Tomas
dc.date.accessioned2016-06-16T13:11:14Zen
dc.date.available2016-06-16T13:11:14Zen
dc.date.issued2016-06en
dc.date.submitted2016en
dc.identifier.citationOccupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study. 2016, 50 (3):181-5 Scand J Urolen
dc.identifier.issn2168-1813en
dc.identifier.pmid26999634en
dc.identifier.doi10.3109/21681805.2016.1151460en
dc.identifier.urihttp://hdl.handle.net/2336/613338en
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractObjective Using centralized registries in Iceland, the aim of this study was to prospectively investigate multiple risk factors for renal cell carcinoma (RCC), including occupational history. Materials and methods From the Reykjavik study database, 18,840 men and women born in the period 1907-1935 were linked with a population-based registry containing all RCCs diagnosed in Iceland from 1971 to 2005 (n = 910). From this cross-reference, altogether 225 cases were identified. A prospective analysis of the risk factors for RCC was performed using Cox regression analysis, from the time of entry into the Reykjavik study to the diagnosis of RCC, death or end of follow-up, with a median follow-up time of 25 years. The hazard ratio (HR) was then calculated for multiple risk factors including occupational history. Results Male gender [HR 1.65, 95% confidence interval (CI) 1.14-2.38], body mass index (BMI) over 25 kg/m² (HR 1.41, 95% CI 1.06-1.88) and age (HR 1.04, 95% CI 1.03-1.07) increased the risk of RCC, as did severe hypertension (>160/100 mmHg) (HR 1.46, 95% CI 1.05-2.03) and history of kidney disease (HR 1.55, 95% CI 1.11-2.16); however, smoking and type 2 diabetes were not significantly associated with the disease. The risk of RCC was significantly increased in painters (HR 2.97, 95% CI 1.31-6.74), aircraft mechanics (HR 4.51, 95% CI 1.11-18.28) and shipbuilders (HR 2.03, 95% CI 1.06-3.84). Conclusions Together with male gender, advanced age, hypertension, BMI over 25 kg/m² and history of kidney disease, the risk of RCC was significantly increased in painters, aircraft mechanics and shipbuilders, suggesting a link to occupational exposure.
dc.language.isoenen
dc.publisherTaylor & Francis Ltden
dc.relation.urlhttp://dx.doi.org/ 10.3109/21681805.2016.1151460en
dc.rightsArchived with thanks to Scandinavian journal of urologyen
dc.subjectNýrnafrumukrabbameinen
dc.subjectAtvinnaen
dc.subjectUmhverfisáhrifen
dc.subjectÁhættumaten
dc.subjectURO12
dc.subjectTAS12
dc.subject.meshOccupationsen
dc.subject.meshEnvironmenten
dc.subject.meshProspective Studiesen
dc.subject.meshCarcinoma, Renal Cellen
dc.subject.meshRisk Factorsen
dc.titleOccupation as a risk factor for renal cell cancer: a nationwide, prospective epidemiological study.en
dc.typeArticleen
dc.contributor.department[ 1 ] Landspitali Univ Hosp, Dept Urol, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 2 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 3 ] Univ Iceland, Iceland Heart Assoc, Reykjavik, Icelanden
dc.identifier.journalScandinavian journal of urologyen
dc.rights.accessClosed - Lokaðen
html.description.abstractObjective Using centralized registries in Iceland, the aim of this study was to prospectively investigate multiple risk factors for renal cell carcinoma (RCC), including occupational history. Materials and methods From the Reykjavik study database, 18,840 men and women born in the period 1907-1935 were linked with a population-based registry containing all RCCs diagnosed in Iceland from 1971 to 2005 (n = 910). From this cross-reference, altogether 225 cases were identified. A prospective analysis of the risk factors for RCC was performed using Cox regression analysis, from the time of entry into the Reykjavik study to the diagnosis of RCC, death or end of follow-up, with a median follow-up time of 25 years. The hazard ratio (HR) was then calculated for multiple risk factors including occupational history. Results Male gender [HR 1.65, 95% confidence interval (CI) 1.14-2.38], body mass index (BMI) over 25 kg/m² (HR 1.41, 95% CI 1.06-1.88) and age (HR 1.04, 95% CI 1.03-1.07) increased the risk of RCC, as did severe hypertension (>160/100 mmHg) (HR 1.46, 95% CI 1.05-2.03) and history of kidney disease (HR 1.55, 95% CI 1.11-2.16); however, smoking and type 2 diabetes were not significantly associated with the disease. The risk of RCC was significantly increased in painters (HR 2.97, 95% CI 1.31-6.74), aircraft mechanics (HR 4.51, 95% CI 1.11-18.28) and shipbuilders (HR 2.03, 95% CI 1.06-3.84). Conclusions Together with male gender, advanced age, hypertension, BMI over 25 kg/m² and history of kidney disease, the risk of RCC was significantly increased in painters, aircraft mechanics and shipbuilders, suggesting a link to occupational exposure.


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