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Changes in IgE sensitization and total IgE levels over 20 years of follow-up.

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Authors
Amaral, André F S
Newson, Roger B
Abramson, Michael J
Antó, Josep M
Bono, Roberto
Corsico, Angelo G
de Marco, Roberto
Demoly, Pascal
Forsberg, Bertil
Gislason, Thorarinn
Heinrich, Joachim
Huerta, Ismael
Janson, Christer
Jõgi, Rain
Kim, Jeong-Lim
Maldonado, José
Martinez-Moratalla Rovira, Jesús
Neukirch, Catherine
Nowak, Dennis
Pin, Isabelle
Probst-Hensch, Nicole
Raherison-Semjen, Chantal
Svanes, Cecilie
Urrutia Landa, Isabel
van Ree, Ronald
Versteeg, Serge A
Weyler, Joost
Zock, Jan-Paul
Burney, Peter G J
Jarvis, Deborah L
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Issue Date
2016-06

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Changes in IgE sensitization and total IgE levels over 20 years of follow-up. 2016, 137 (6):1788-1795.e9 J. Allergy Clin. Immunol.
Abstract
Cross-sectional studies have reported a lower prevalence of sensitization in older adults, but few longitudinal studies have examined whether this is an aging or a year-of-birth cohort effect.
We sought to assess changes in sensitization and total IgE levels in a cohort of European adults as they aged over a 20-year period.
Levels of serum specific IgE to common aeroallergens (house dust mite, cat, and grass) and total IgE levels were measured in 3206 adults from 25 centers in the European Community Respiratory Health Survey on 3 occasions over 20 years. Changes in sensitization and total IgE levels were analyzed by using regression analysis corrected for potential differences in laboratory equipment and by using inverse sampling probability weights to account for nonresponse.
Over the 20-year follow-up, the prevalence of sensitization to at least 1 of the 3 allergens decreased from 29.4% to 24.8% (-4.6%; 95% CI, -7.0% to -2.1%). The prevalence of sensitization to house dust mite (-4.3%; 95% CI, -6.0% to -2.6%) and cat (-2.1%; 95% CI, -3.6% to -0.7%) decreased more than sensitization to grass (-0.6%; 95% CI, -2.5% to 1.3%). Age-specific prevalence of sensitization to house dust mite and cat did not differ between year-of-birth cohorts, but sensitization to grass was most prevalent in the most recent ones. Overall, total IgE levels decreased significantly (geometric mean ratio, 0.63; 95% CI, 0.58-0.68) at all ages in all year-of-birth cohorts.
Aging was associated with lower levels of sensitization, especially to house dust mite and cat, after the age of 20 years.
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To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.
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http://dx.doi.org/ 10.1016/j.jaci.2015.09.037
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889785/
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Archived with thanks to The Journal of allergy and clinical immunology
ae974a485f413a2113503eed53cd6c53
10.1016/j.jaci.2015.09.037
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