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dc.contributor.authorOlivecrona, Göran K
dc.contributor.authorLagerqvist, Bo
dc.contributor.authorFröbert, Ole
dc.contributor.authorGudnason, Thórarinn
dc.contributor.authorMaeng, Michael
dc.contributor.authorRåmunddal, Truls
dc.contributor.authorHaupt, Jan
dc.contributor.authorKellerth, Thomas
dc.contributor.authorStewart, Jason
dc.contributor.authorSarno, Giovanna
dc.contributor.authorJensen, Jens
dc.contributor.authorÖstlund, Ollie
dc.contributor.authorJames, Stefan K
dc.date.accessioned2016-08-17T11:29:50Z
dc.date.available2016-08-17T11:29:50Z
dc.date.issued2016
dc.date.submitted2016
dc.identifier.citationImpact of thrombus aspiration during ST-Elevation Myocardial Infarction: a six month composite endpoint and risk of stroke analyses of the TASTE trial. 2016, 16:62 BMC Cardiovasc Disorden
dc.identifier.issn1471-2261
dc.identifier.pmid27036735
dc.identifier.doi10.1186/s12872-016-0238-y
dc.identifier.urihttp://hdl.handle.net/2336/618489
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractRoutine thrombus aspiration during primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) did not reduce the primary composite endpoint in the "A Randomised Trial of Routine Aspiration ThrOmbecTomy With PCI Versus PCI ALone in Patients With STEMI Undergoing Primary PCI" (TOTAL) trial. We aimed to analyse a similar endpoint in "The Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia" (TASTE) trial up to 180 days.
dc.description.abstractIn TASTE, 7244 patients with STEMI were randomised to thrombus aspiration followed by PCI or to PCI alone. We analysed the quadruple composite endpoint of cardiovascular death, cardiogenic shock, rehospitalisation for myocardial infarction, or new hospitalisation for heart failure. Furthermore, an extended net-benefit composite endpoint including stent thrombosis, target vessel revascularization or stroke within 180 days was analysed.
dc.description.abstractThe primary quadruple composite endpoint occurred in 8.7 % (316 of 3621) in the thrombus aspiration group compared to 9.3 % (338 of 3623) in the PCI alone group (hazard ratio (HR), 0.93; 95 % confidence interval (CI); 0.80 - 1.09, P = 0.36) and the extended net-benefit composite endpoint in 12.0 % (436) vs. 13.2 % (479) (HR, 0.90; 95 % CI; 0.79 - 1.03, P = 0.12). Stroke within 30 days occurred in 0.7 % (27) vs. 0.7 % (24) (HR, 0.89; 95 % CI; 0.51-1.54, P = 0.68).
dc.description.abstractA large and an extended composite endpoint analysis from the TASTE trial did not demonstrate any clinical benefit of routine thrombus aspiration during PCI in patients with STEMI. There was no evidence of an increased risk of stroke with thrombus aspiration.
dc.description.sponsorshipSwedish Research Council Swedish Association of Local Authorities and Regions Terumo Medical Corporation Medtronic Vascular Solutions Swedish Heart-Lung Foundation 20100178 B0010401en
dc.language.isoenen
dc.publisherBioMed Central Ltden
dc.relation.urlhttp://dx.doi.org/ 10.1186/s12872-016-0238-yen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818511/en
dc.rightsArchived with thanks to BMC cardiovascular disordersen
dc.subjectKransæðasjúkdómaren
dc.subjectHjarta- og æðasjúkdómaren
dc.subjectCAR12
dc.subject.meshMyocardial Infarctionen
dc.subject.meshThrombectomyen
dc.subject.meshStroke/epidemiologyen
dc.subject.meshCoronary Thrombosis/therapyen
dc.subject.meshCardiovascular Diseases/mortalityen
dc.titleImpact of thrombus aspiration during ST-Elevation Myocardial Infarction: a six month composite endpoint and risk of stroke analyses of the TASTE trial.en
dc.typeArticleen
dc.contributor.department[ 1 ] Lund Univ, Skane Univ Hosp, Dept Cardiol, S-22185 Lund, Sweden [ 2 ] Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden [ 3 ] Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden [ 4 ] Univ Orebro, Fac Hlth, Dept Cardiol, SE-70182 Orebro, Sweden [ 5 ] Landspitali Univ Hosp, Dept Cardiol, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 6 ] Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, Denmark [ 7 ] Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, Denmark [ 8 ] Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden [ 9 ] Sunderby Hosp, PCI Unit, Sunderby, Sweden [ 10 ] Skaraborgs Hosp, Dept Cardiol, Skovde, Sweden [ 11 ] Karolinska Inst, Dept Cardiol, Stockholm, Sweden [ 12 ] Sundsvall Hosp, Sundsvall, Swedenen
dc.identifier.journalBMC cardiovascular disordersen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T16:07:52Z
html.description.abstractRoutine thrombus aspiration during primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) did not reduce the primary composite endpoint in the "A Randomised Trial of Routine Aspiration ThrOmbecTomy With PCI Versus PCI ALone in Patients With STEMI Undergoing Primary PCI" (TOTAL) trial. We aimed to analyse a similar endpoint in "The Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia" (TASTE) trial up to 180 days.
html.description.abstractIn TASTE, 7244 patients with STEMI were randomised to thrombus aspiration followed by PCI or to PCI alone. We analysed the quadruple composite endpoint of cardiovascular death, cardiogenic shock, rehospitalisation for myocardial infarction, or new hospitalisation for heart failure. Furthermore, an extended net-benefit composite endpoint including stent thrombosis, target vessel revascularization or stroke within 180 days was analysed.
html.description.abstractThe primary quadruple composite endpoint occurred in 8.7 % (316 of 3621) in the thrombus aspiration group compared to 9.3 % (338 of 3623) in the PCI alone group (hazard ratio (HR), 0.93; 95 % confidence interval (CI); 0.80 - 1.09, P = 0.36) and the extended net-benefit composite endpoint in 12.0 % (436) vs. 13.2 % (479) (HR, 0.90; 95 % CI; 0.79 - 1.03, P = 0.12). Stroke within 30 days occurred in 0.7 % (27) vs. 0.7 % (24) (HR, 0.89; 95 % CI; 0.51-1.54, P = 0.68).
html.description.abstractA large and an extended composite endpoint analysis from the TASTE trial did not demonstrate any clinical benefit of routine thrombus aspiration during PCI in patients with STEMI. There was no evidence of an increased risk of stroke with thrombus aspiration.


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