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dc.contributor.authorThorsteinsdottir, Ingunn
dc.contributor.authorAspelund, Thor
dc.contributor.authorGudmundsson, Elias
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorHarris, Tamara B
dc.contributor.authorLauner, Lenore J
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorVenge, Per
dc.date.accessioned2016-08-17T11:43:26Z
dc.date.available2016-08-17T11:43:26Z
dc.date.issued2016-04
dc.date.submitted2016
dc.identifier.citationHigh-Sensitivity Cardiac Troponin I Is a Strong Predictor of Cardiovascular Events and Mortality in the AGES-Reykjavik Community-Based Cohort of Older Individuals. 2016, 62 (4):623-30 Clin. Chem.en
dc.identifier.issn1530-8561
dc.identifier.pmid26936931
dc.identifier.doi10.1373/clinchem.2015.250811
dc.identifier.urihttp://hdl.handle.net/2336/618496
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractThe objective of this study was to investigate the predictive power of a high-sensitivity cardiac troponin I (hs-cTnI) assay for cardiovascular events and mortality in a large population of older community dwellers.
dc.description.abstractBlood was collected from 5764 individuals (age 66-98 years) during the period of 2002-2006 and the outcome as to all-cause death and incidence of cardiovascular disease (CVD) and coronary heart disease (CHD) followed up to 10 years. hs-cTnI (Abbott) was measured in serum to assess the association of this marker with CVD, CHD and death, and finally, to compare the results with conventional risk factors by multivariable statistical analysis.
dc.description.abstractThe median (interquartile range) concentrations of hs-cTnI were 8.4 ng/L (5.6-14.2 ng/L) and 5.3 ng/L (3.8-8.1 ng/L) in men (2416) and women (3275), respectively, and the concentrations increased linearly with age. Outcomes as to all-cause death and incidence of CVD and CHD were significantly associated with increasing concentrations of hs-cTnI beginning well below the 99th percentile concentrations. The associations with outcome remained after adjustments for conventional risk factors and were similar in men and women.
dc.description.abstractOur findings suggest that hs-cTnI reflects the status of the myocardium even in seemingly healthy individuals and that the measurements of hs-cTnI may be useful for primary prediction of heart disease; this should form the basis for future prospective clinical trials for determining whether measuring hs-cTnI can be used in the prevention of CVD/CHD.
dc.description.sponsorshipNational Institutes of Health, USA N01-AG-12100 National Institute on Aging Intramural Research Program, the National Eye Institute USA Z01-EY000401 National Institutes of Health Hjartavernd (the Icelandic Heart Association) Althingi (Icelandic Parliament) Abbott Diagnosticsen
dc.language.isoenen
dc.publisherAmer Assoc Clinical Chemistryen
dc.relation.urlhttp://dx.doi.org/10.1373/clinchem.2015.250811en
dc.relation.urlhttp://www.clinchem.org/content/62/4/623.full.pdfen
dc.rightsArchived with thanks to Clinical chemistryen
dc.subjectHjartasjúkdómaren
dc.subjectAldraðiren
dc.subjectMAB12
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshAgingen
dc.subject.meshBiomarkersen
dc.subject.meshCardiovascular Diseasesen
dc.subject.meshCause of Deathen
dc.subject.meshCohort Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshIncidenceen
dc.subject.meshMaleen
dc.subject.meshMultivariate Analysisen
dc.subject.meshPredictive Value of Testsen
dc.subject.meshProspective Studiesen
dc.subject.meshRisk Factorsen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshTroponin Ien
dc.titleHigh-Sensitivity Cardiac Troponin I Is a Strong Predictor of Cardiovascular Events and Mortality in the AGES-Reykjavik Community-Based Cohort of Older Individuals.en
dc.typeArticleen
dc.contributor.department[ 1 ] Iceland Heart Assoc, Res Inst, Kopavogur, Iceland [ 2 ] Landspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 3 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 4 ] NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD 20892 USA [ 5 ] Uppsala Univ, Dept Med Sci, Uppsala, Swedenen
dc.identifier.journalClinical chemistryen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractThe objective of this study was to investigate the predictive power of a high-sensitivity cardiac troponin I (hs-cTnI) assay for cardiovascular events and mortality in a large population of older community dwellers.
html.description.abstractBlood was collected from 5764 individuals (age 66-98 years) during the period of 2002-2006 and the outcome as to all-cause death and incidence of cardiovascular disease (CVD) and coronary heart disease (CHD) followed up to 10 years. hs-cTnI (Abbott) was measured in serum to assess the association of this marker with CVD, CHD and death, and finally, to compare the results with conventional risk factors by multivariable statistical analysis.
html.description.abstractThe median (interquartile range) concentrations of hs-cTnI were 8.4 ng/L (5.6-14.2 ng/L) and 5.3 ng/L (3.8-8.1 ng/L) in men (2416) and women (3275), respectively, and the concentrations increased linearly with age. Outcomes as to all-cause death and incidence of CVD and CHD were significantly associated with increasing concentrations of hs-cTnI beginning well below the 99th percentile concentrations. The associations with outcome remained after adjustments for conventional risk factors and were similar in men and women.
html.description.abstractOur findings suggest that hs-cTnI reflects the status of the myocardium even in seemingly healthy individuals and that the measurements of hs-cTnI may be useful for primary prediction of heart disease; this should form the basis for future prospective clinical trials for determining whether measuring hs-cTnI can be used in the prevention of CVD/CHD.


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