The Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationThe Urban-Rural Gradient In Asthma: A Population-Based Study in Northern Europe. 2016, 13 (1):93 Int J Environ Res Public Health
AbstractThe early life environment appears to have a persistent impact on asthma risk. We hypothesize that environmental factors related to rural life mediate lower asthma prevalence in rural populations, and aimed to investigate an urban-rural gradient, assessed by place of upbringing, for asthma. The population-based Respiratory Health In Northern Europe (RHINE) study includes subjects from Denmark, Norway, Sweden, Iceland and Estonia born 1945-1973. The present analysis encompasses questionnaire data on 11,123 RHINE subjects. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb and inner city. The association of place of upbringing with asthma onset was analysed with Cox regression adjusted for relevant confounders. Subjects growing up on livestock farms had less asthma (8%) than subjects growing up in inner cities (11%) (hazard ratio 0.72 95% CI 0.57-0.91), and a significant urban-rural gradient was observed across six urbanisation levels (p = 0.02). An urban-rural gradient was only evident among women, smokers and for late-onset asthma. Analyses on wheeze and place of upbringing revealed similar results. In conclusion, this study suggests a protective effect of livestock farm upbringing on asthma development and an urban-rural gradient in a Northern European population.
DescriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.
RightsArchived with thanks to International journal of environmental research and public health
- Place of upbringing in early childhood as related to inflammatory bowel diseases in adulthood: a population-based cohort study in Northern Europe.
- Authors: Timm S, Svanes C, Janson C, Sigsgaard T, Johannessen A, Gislason T, Jogi R, Omenaas E, Forsberg B, Torén K, Holm M, Bråbäck L, Schlünssen V
- Issue date: 2014 Jun
- A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe.
- Authors: Christensen SH, Timm S, Janson C, Benediktsdóttir B, Forsberg B, Holm M, Jogi R, Johannessen A, Omenaas E, Sigsgaard T, Svanes C, Schlünssen V
- Issue date: 2016
- The effects of growing up on a farm on adult lung function and allergic phenotypes: an international population-based study.
- Authors: Campbell B, Raherison C, Lodge CJ, Lowe AJ, Gislason T, Heinrich J, Sunyer J, Gómez Real F, Norbäck D, Matheson MC, Wjst M, Dratva J, de Marco R, Jarvis D, Schlünssen V, Janson C, Leynaert B, Svanes C, Dharmage SC
- Issue date: 2017 Mar
- Contact with livestock--a protective effect against allergies and asthma?
- Authors: Dimich-Ward H, Chow Y, Chung J, Trask C
- Issue date: 2006 Sep
- Prevalence of wheeze and asthma and relation to atopy in urban and rural Ethiopia.
- Authors: Yemaneberhan H, Bekele Z, Venn A, Lewis S, Parry E, Britton J
- Issue date: 1997 Jul 12