Show simple item record

dc.contributor.authorOrmarsson, Orri Thor
dc.contributor.authorAsgrimsdottir, Gudrun Marta
dc.contributor.authorLoftsson, Thorsteinn
dc.contributor.authorStefansson, Einar
dc.contributor.authorLund, Sigrun Helga
dc.contributor.authorBjornsson, Einar Stefan
dc.date.accessioned2016-08-24T10:31:46Z
dc.date.available2016-08-24T10:31:46Z
dc.date.issued2016-06
dc.date.submitted2016
dc.identifier.citationFree fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children. 2016, 105 (6):689-94 Acta Paediatr.en
dc.identifier.issn1651-2227
dc.identifier.pmid26948070
dc.identifier.doi10.1111/apa.13394
dc.identifier.urihttp://hdl.handle.net/2336/618737
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractA well-documented, clinically proven per rectum treatment for childhood constipation is needed. This phase two clinical trial evaluated the efficacy of suppositories containing free fatty acids (FFA) compared with Klyx docusate sodium and sorbitol enemas.
dc.description.abstractA randomised, controlled, single-blind study was undertaken on 77 children aged between one and 17 who presented to an emergency department in Iceland and were diagnosed with constipation. In stage one, 23 patients were randomised to receive lower dose FFA suppositories or Klyx (n = 33). In stage two, 21 different patients were randomised to receive higher dose suppositories and compared with the same Klyx control subjects.
dc.description.abstractThe suppositories were effective at bowel emptying in 39% of the group who received the lower FFA doses and 81% of the group receiving higher doses, compared with 88% in the Klyx control group. Symptom relief was obtained in 30% of the group receiving the lower doses and 71% of the group receiving the higher doses, compared with 73% in the control group.
dc.description.abstractThe higher dose FFA suppositories were as effective as the Klyx enemas with regard to bowel emptying and symptom relief and might provide an important and less invasive alternative for childhood constipation.
dc.description.sponsorshipTechnology Development Fund of Iceland,en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://dx.doi.org/ 10.1111/apa.13394en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/apa.13394/epdfen
dc.rightsArchived with thanks to Acta paediatrica (Oslo, Norway : 1992)en
dc.subjectPES12
dc.subjectOPH12
dc.subjectGAS12
dc.subject.meshConstipationen
dc.subject.meshFatty Acids, Nonesterifieden
dc.subject.meshLaxativesen
dc.subject.meshSuppositoriesen
dc.subject.meshClinical Trialen
dc.titleFree fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in children.en
dc.typeArticleen
dc.contributor.department1Landspitali-University Hospital, Reykjavík, Iceland. 2Lipid Pharmaceuticals, Reykjavík, Iceland. 3University of Iceland, Reykjavík, Iceland.en
dc.identifier.journalActa paediatrica (Oslo, Norway : 1992)en
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractA well-documented, clinically proven per rectum treatment for childhood constipation is needed. This phase two clinical trial evaluated the efficacy of suppositories containing free fatty acids (FFA) compared with Klyx docusate sodium and sorbitol enemas.
html.description.abstractA randomised, controlled, single-blind study was undertaken on 77 children aged between one and 17 who presented to an emergency department in Iceland and were diagnosed with constipation. In stage one, 23 patients were randomised to receive lower dose FFA suppositories or Klyx (n = 33). In stage two, 21 different patients were randomised to receive higher dose suppositories and compared with the same Klyx control subjects.
html.description.abstractThe suppositories were effective at bowel emptying in 39% of the group who received the lower FFA doses and 81% of the group receiving higher doses, compared with 88% in the Klyx control group. Symptom relief was obtained in 30% of the group receiving the lower doses and 71% of the group receiving the higher doses, compared with 73% in the control group.
html.description.abstractThe higher dose FFA suppositories were as effective as the Klyx enemas with regard to bowel emptying and symptom relief and might provide an important and less invasive alternative for childhood constipation.


This item appears in the following Collection(s)

Show simple item record