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dc.contributor.authorHelgadottir, S
dc.contributor.authorSigurdsson, M I
dc.contributor.authorPalsson, R
dc.contributor.authorHelgason, D
dc.contributor.authorSigurdsson, G H
dc.contributor.authorGudbjartsson, T
dc.date.accessioned2016-10-14T14:26:11Z
dc.date.available2016-10-14T14:26:11Z
dc.date.issued2016-10
dc.date.submitted2016
dc.identifier.citationRenal recovery and long-term survival following acute kidney injury after coronary artery surgery: a nationwide study. 2016, 60 (9):1230-40 Acta Anaesthesiol Scanden
dc.identifier.issn1399-6576
dc.identifier.pmid27378715
dc.identifier.doi10.1111/aas.12758
dc.identifier.otherTAS12
dc.identifier.otherIAM12
dc.identifier.otherAAA12
dc.identifier.otherNEU12
dc.identifier.urihttp://hdl.handle.net/2336/620044
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractAcute kidney injury (AKI) is a relatively common complication following CABG and is associated with adverse outcomes. Nonetheless, we hypothesized that the majority of patients make a good long-term recovery of their renal function. We studied the incidence and risk factors of AKI together with renal recovery and long-term survival in patients who developed AKI following CABG.
dc.description.abstractThis nationwide study examined AKI among 1754 consecutive patients undergoing CABG in 2001-2013. AKI was defined according to the KDIGO criteria.
dc.description.abstractPostoperatively 184 (11%) patients developed AKI; 121 (7%), 27 (2%), and 36 (2%) at stages 1, 2, and 3, respectively. AKI was an independent risk factor for chronic kidney disease (CKD) and AKI patients had worse post-operative outcomes. Lower pre-operative glomerular filtration rate, higher EuroSCORE and BMI, diabetes, reoperation, and units of red blood cells transfused were independent risk factors of AKI. At post-operative day 10, renal recovery rates, defined as serum creatinine ratio <1.25 of baseline, were 96 (95% CI 91-99%), 78 (95% CI 53-90%), and 94% (95% CI 77-98%) for AKI stages 1, 2, and 3, respectively. Long-term survival was predicted by AKI with 10-year survival of patients without AKI being 76% and those with AKI stages 1, 2, and 3 being 63%, 56%, and 49%, respectively (P < 0.001).
dc.description.abstractDepending on the severity of the initial AKI, 78-97% of patients made good recovery of their kidney function. However, AKI was significantly linked to progression to CKD and long-term survival remained markedly affected by the severity of the initial kidney injury.
dc.description.sponsorshipLandspitali University University of Iceland Research Fund Helga Gudmundsdottir and Sigurlidi Kristjansson Memorial Funden
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.relation.urlhttp://dx.doi.org/ 10.1111/aas.12758en
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aas.12758/epdfen
dc.rightsArchived with thanks to Acta anaesthesiologica Scandinavicaen
dc.subjectNýrnabilunen
dc.subjectNýru
dc.subjectHjartaaðgerðir
dc.subjectNEP12
dc.subjectAAA12
dc.subjectTAS12
dc.subject.meshAcute Kidney Injuryen
dc.subject.meshCardiac Surgical Procedures/adverse effectsen
dc.subject.meshstoperative Complicationsen
dc.titleRenal recovery and long-term survival following acute kidney injury after coronary artery surgery: a nationwide study.en
dc.typeArticleen
dc.contributor.department[ 1 ] Landspitali Univ Hosp, Dept Cardiothorac Surg, IS-101 Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 2 ] Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA [ 3 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 4 ] Landspitali Univ Hosp, Dept Nephrol, Reykjavik, Iceland   Organization-Enhanced Name(s)      Landspitali National University Hospital [ 5 ] Landspitali Univ Hosp, Dept Anesthesia & Intens Care Med, Reykjavik, Icelanden
dc.identifier.journalActa anaesthesiologica Scandinavicaen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractAcute kidney injury (AKI) is a relatively common complication following CABG and is associated with adverse outcomes. Nonetheless, we hypothesized that the majority of patients make a good long-term recovery of their renal function. We studied the incidence and risk factors of AKI together with renal recovery and long-term survival in patients who developed AKI following CABG.
html.description.abstractThis nationwide study examined AKI among 1754 consecutive patients undergoing CABG in 2001-2013. AKI was defined according to the KDIGO criteria.
html.description.abstractPostoperatively 184 (11%) patients developed AKI; 121 (7%), 27 (2%), and 36 (2%) at stages 1, 2, and 3, respectively. AKI was an independent risk factor for chronic kidney disease (CKD) and AKI patients had worse post-operative outcomes. Lower pre-operative glomerular filtration rate, higher EuroSCORE and BMI, diabetes, reoperation, and units of red blood cells transfused were independent risk factors of AKI. At post-operative day 10, renal recovery rates, defined as serum creatinine ratio <1.25 of baseline, were 96 (95% CI 91-99%), 78 (95% CI 53-90%), and 94% (95% CI 77-98%) for AKI stages 1, 2, and 3, respectively. Long-term survival was predicted by AKI with 10-year survival of patients without AKI being 76% and those with AKI stages 1, 2, and 3 being 63%, 56%, and 49%, respectively (P < 0.001).
html.description.abstractDepending on the severity of the initial AKI, 78-97% of patients made good recovery of their kidney function. However, AKI was significantly linked to progression to CKD and long-term survival remained markedly affected by the severity of the initial kidney injury.


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