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dc.contributor.authorEinarsson, Einar-Jón
dc.contributor.authorPatel, Mitesh
dc.contributor.authorPetersen, Hannes
dc.contributor.authorWiebe, Thomas
dc.contributor.authorFransson, Per-Anders
dc.contributor.authorMagnusson, Måns
dc.contributor.authorMoëll, Christian
dc.date.accessioned2016-11-14T15:48:43Z
dc.date.available2016-11-14T15:48:43Z
dc.date.issued2016-11-10
dc.date.submitted2016
dc.identifier.citationDecreased postural control in adult survivors of childhood cancer treated with chemotherapy. 2016, 6:36784 Sci Repen
dc.identifier.issn2045-2322
dc.identifier.pmid27830766
dc.identifier.doihttp://dx.doi.org/10.1038/srep36784
dc.identifier.urihttp://hdl.handle.net/2336/620063
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.en
dc.description.abstractThe objective of cancer treatment is to secure survival. However, as chemotherapeutic agents can affect the central and peripheral nervous systems, patients must undergo a process of central compensation. We explored the effectiveness of this compensation process by measuring postural behaviour in adult survivors of childhood cancer treated with chemotherapy (CTS). We recruited sixteen adults treated with chemotherapy in childhood for malignant solid (non-CNS) tumours and 25 healthy age-matched controls. Subjects performed posturography with eyes open and closed during quiet and perturbed standing. Repeated balance perturbations through calf vibrations were used to study postural adaptation. Subjects were stratified into two groups (treatment before or from 12 years of age) to determine age at treatment effects. Both quiet (p = 0.040) and perturbed standing (p ≤ 0.009) were significantly poorer in CTS compared to controls, particularly with eyes open and among those treated younger. Moreover, CTS had reduced levels of adaptation compared to controls, both with eyes closed and open. Hence, adults treated with chemotherapy for childhood cancer may suffer late effects of poorer postural control manifested as reduced contribution of vision and as reduced adaptation skills. These findings advocate development of chemotherapeutic agents that cause fewer long-term side effects when used for treating children.
dc.description.sponsorshipSwedish Medical Research Council/ 17x-05693, the Medical Faculty, Lund University, Sweden, Skåne County Council’s research and development foundation.en
dc.languageENG
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttp://dx.doi.org/10.1038/srep36784en
dc.rightsArchived with thanks to Scientific reportsen
dc.subjectKrabbameinen
dc.subjectBörnen
dc.subjectLíkamsbeitingen
dc.subjectLyfjameðferðen
dc.subjectSjónskerðingen
dc.subjectOTO12
dc.subject.meshPostural Balanceen
dc.subject.meshPostureen
dc.subject.meshMuscle, Skeletalen
dc.subject.meshDrug Therapyen
dc.subject.meshNeoplasmsen
dc.subject.meshChilden
dc.subject.meshVision, Ocularen
dc.titleDecreased postural control in adult survivors of childhood cancer treated with chemotherapy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Sciences, Lund University, Lund, Sweden. 2Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 3Division of Brain Sciences, Imperial College London, London, United Kingdom. 4Department of Otorhinolaryngology, Landspitali University Hospital, Reykjavik, Iceland. 5Department of Paediatrics, Skåne University Hospital, Lund, Sweden. 6Department of Otorhinolaryngology, Skåne University Hospital, Lund, Sweden.en
dc.identifier.journalScientific reportsen
dc.rights.accessOpen Accessen
refterms.dateFOA2018-09-12T16:19:25Z
html.description.abstractThe objective of cancer treatment is to secure survival. However, as chemotherapeutic agents can affect the central and peripheral nervous systems, patients must undergo a process of central compensation. We explored the effectiveness of this compensation process by measuring postural behaviour in adult survivors of childhood cancer treated with chemotherapy (CTS). We recruited sixteen adults treated with chemotherapy in childhood for malignant solid (non-CNS) tumours and 25 healthy age-matched controls. Subjects performed posturography with eyes open and closed during quiet and perturbed standing. Repeated balance perturbations through calf vibrations were used to study postural adaptation. Subjects were stratified into two groups (treatment before or from 12 years of age) to determine age at treatment effects. Both quiet (p = 0.040) and perturbed standing (p ≤ 0.009) were significantly poorer in CTS compared to controls, particularly with eyes open and among those treated younger. Moreover, CTS had reduced levels of adaptation compared to controls, both with eyes closed and open. Hence, adults treated with chemotherapy for childhood cancer may suffer late effects of poorer postural control manifested as reduced contribution of vision and as reduced adaptation skills. These findings advocate development of chemotherapeutic agents that cause fewer long-term side effects when used for treating children.


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