Show simple item record

dc.contributor.authorJuliusson, Gunnar
dc.contributor.authorJonasson, Jon Gunnlaugur
dc.contributor.authorJonsdottir, Sara B
dc.contributor.authorGarcia, Henrik G
dc.contributor.authorOlafsdottir, Elinborg
dc.contributor.authorMöller, Pall Helgi
dc.contributor.authorBjörnsson, Einar S
dc.date.accessioned2016-12-07T14:56:01Z
dc.date.available2016-12-07T14:56:01Z
dc.date.issued2016-12
dc.date.submitted2016
dc.identifier.citationBiliary tract malignancies: a population-based study on incidence, prognosis and management of patients. 2016, 51 (12):1520-1525 Scand. J. Gastroenterol.en
dc.identifier.issn1502-7708
dc.identifier.pmid27553174
dc.identifier.doi10.1080/00365521.2016.1218538
dc.identifier.urihttp://hdl.handle.net/2336/620090
dc.descriptionTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractBiliary tract malignancies are uncommon and few population-based studies are available.
dc.description.abstractThis nationwide population-based study in Iceland included all patients diagnosed with intra- and extrahepatic cholangiocarcinoma, gallbladder and ampullary cancer from 1984 to 2012. Patients were identified through the Icelandic Cancer Registry. Clinical information was obtained from patient records.
dc.description.abstractOverall 245 patients were identified: 38 had intrahepatic cholangiocarcinoma, 66 extrahepatic cholangiocarcinoma, 73 gallbladder cancer (GBC) and 68 ampullary cancer. Overall incidence for bile tract malignancies was 1-3 per 100,000 person-years and less than 1 by sub-type. The overall bile tract malignancies in males increased from 1.3 (95% CI 0.8-1.8) to 2.5 (1.9-3.1) per 100,000 inhabitants. The incidence of GBC among females decreased from 1.1 (0.7-1.5) to 0.5 (0.2-0.7). Surgery decreased for extrahepatic cholangiocarcinoma (56 to 23%, p = .027), ampullary cancer (80 to 48%, p = .03) and overall bile tract cancer (61 to 32%, p < .0001) but use of chemotherapy increased (4 to 32%, p < .0001). Five-year relative survival rates for men were 15% and 24% for women. No significant improvement was found in survival.
dc.description.abstractOverall incidence of bile tract malignancies increased in males and GBC decreased in women. Long-term survival is poor and did not improve despite changes in treatment.
dc.language.isoenen
dc.publisherTaylor & Francis Ltden
dc.relationxen
dc.relation.urlhttp://dx.doi.org/ 10.1080/00365521.2016.1218538en
dc.relation.urlhttp://www.tandfonline.com/doi/pdf/10.1080/00365521.2016.1218538?needAccess=trueen
dc.rightsclosedAccessen
dc.subjectGallblaðraen
dc.subjectKrabbameinen
dc.subjectLífslíkuren
dc.subjectGAS12
dc.subject.meshCholangiocarcinomaen
dc.subject.meshGallbladder Neoplasmsen
dc.subject.meshSurvivalen
dc.subject.meshIcelanden
dc.titleBiliary tract malignancies: a population-based study on incidence, prognosis and management of patients.en
dc.typearticleen
dc.contributor.department1a Department of Gastroenterology and Hepatology , Landspitali University Hospital , Reykjavik , Iceland. 2b Department of Pathology , Landspitali University Hospital , Reykjavik , Iceland. 3c Faculty of Medicine , University of Iceland , Reykjavik , Iceland. 4d Icelandic Cancer Registry, Icelandic Cancer Society , Reykjavik , Iceland. 5e Department of Surgery , Landspitali University Hospital , Reykjavik , Iceland.en
dc.identifier.journalScandinavian journal of gastroenterologyen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractBiliary tract malignancies are uncommon and few population-based studies are available.
html.description.abstractThis nationwide population-based study in Iceland included all patients diagnosed with intra- and extrahepatic cholangiocarcinoma, gallbladder and ampullary cancer from 1984 to 2012. Patients were identified through the Icelandic Cancer Registry. Clinical information was obtained from patient records.
html.description.abstractOverall 245 patients were identified: 38 had intrahepatic cholangiocarcinoma, 66 extrahepatic cholangiocarcinoma, 73 gallbladder cancer (GBC) and 68 ampullary cancer. Overall incidence for bile tract malignancies was 1-3 per 100,000 person-years and less than 1 by sub-type. The overall bile tract malignancies in males increased from 1.3 (95% CI 0.8-1.8) to 2.5 (1.9-3.1) per 100,000 inhabitants. The incidence of GBC among females decreased from 1.1 (0.7-1.5) to 0.5 (0.2-0.7). Surgery decreased for extrahepatic cholangiocarcinoma (56 to 23%, p = .027), ampullary cancer (80 to 48%, p = .03) and overall bile tract cancer (61 to 32%, p < .0001) but use of chemotherapy increased (4 to 32%, p < .0001). Five-year relative survival rates for men were 15% and 24% for women. No significant improvement was found in survival.
html.description.abstractOverall incidence of bile tract malignancies increased in males and GBC decreased in women. Long-term survival is poor and did not improve despite changes in treatment.


This item appears in the following Collection(s)

Show simple item record