Strain- and time-dependent alterations in hepatic iron metabolism in a murine model of nonalcoholic steatohepatitis.
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AuthorsBloomer, Steven A
Olivier, Alicia K
Bergmann, Ottar M
Mathahs, M Meleah
Broadhurst, Kimberly A
Brown, Kyle E
MetadataShow full item record
CitationStrain- and time-dependent alterations in hepatic iron metabolism in a murine model of nonalcoholic steatohepatitis. 2016, 34 (8):628-639 Cell Biochem. Funct.
AbstractNonalcoholic steatohepatitis (NASH) is a common liver disease that often accompanies the metabolic syndrome. The latter condition has been linked to iron deficiency and diminished intestinal iron absorption, likely the result of hepcidin upregulation by chronic inflammation. Paradoxically, some NASH patients accumulate excess hepatic iron, which may increase fibrosis and cancer risk. Iron accumulation has been attributed to suppression of hepcidin by oxidative stress. The objective of this study was to investigate the contributions of inflammation and oxidative stress to altered hepatic iron metabolism in a murine model of NASH using inbred strains of mice with differing susceptibilities to injury.
DescriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open To access publisher's full text version of this article click on the hyperlink at the bottom of the page
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