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dc.contributor.authorThorhallsdottir, Anna Kristin
dc.contributor.authorGislason, David
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorClausen, Michael
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorJanson, Christer
dc.contributor.authorBenediktsdottir, Bryndis
dc.date.accessioned2017-01-26T14:48:59Z
dc.date.available2017-01-26T14:48:59Z
dc.date.issued2016-11-30
dc.date.submitted2017
dc.identifier.citationExhaled nitric oxide in a middle-aged Icelandic population cohort. 2016, 10 (4):046015 J Breath Resen
dc.identifier.issn1752-7163
dc.identifier.pmid27902492
dc.identifier.doi10.1088/1752-7155/10/4/046015
dc.identifier.urihttp://hdl.handle.net/2336/620101
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open To access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractThe prevalence of atopy and asthma is relatively low in Iceland. The purpose of this study was to describe exhaled nitric oxide (FeNO) levels in the general population in correlation with demographic characteristics, smoking status, asthma, rhinitis, atopic status and lung function tests. Altogether 403 subjects, from the European Community Respiratory Health Survey (ECRHS) III who answered the main questionnaire and were checked by FeNO measurements, lung function testing, skin prick testing and measurement of total IgE and specific IgE were included. The geometric mean (95% CI) of FeNO was 16.2 ppb (15.2-17.1) and the prevalence of higher FeNO (⩾25 ppb) was 19.5% in the random sample. Subjects with higher FeNO levels were less likely to be current smokers and more likely to have asthma and rhinitis. Having higher FeNO values was also associated with higher total IgE, having specific IgE to at least one allergen and being skin prick test positive. Current smokers had significantly lower levels of FeNO, geometric mean (95% CI) 9.6 ppb (8.4-11.0), than ex-smokers 18.2 ppb (16.6-20.0) and never smokers 17.3 ppb (16.1-18.5). In multivariable models, having asthma (OR (95% CI) 2.10 (1.20-3.67)), having a specific IgE (OR 2.30 (1.25-4.23)) and being skin prick test positive (OR 2.06 (1.18-3.60)) were independently positively associated with a higher FeNO (⩾25) whereas current smoking was independently negatively associated with a higher FeNO (OR 0.19 (0.06-0.63)). Higher levels of FeNO (⩾25 ppb) were found in one out of five Icelanders; FeNO was positively associated with asthma and allergy and negatively with smoking.
dc.description.sponsorshipLandspitali University Science Fund Icelandic General Practitioner's Science Fund Icelandic Asthma and Allergy Foundationen
dc.language.isoenen
dc.publisherIOP Pub.en
dc.relationxxxen
dc.relation.urlhttp://iopscience.iop.org/article/10.1088/1752-7155/10/4/046015/pdfen
dc.rightsclosedAccessen
dc.subjectÖndunarfærasjúkdómaren
dc.subjectAsmaen
dc.subjectOfnæmien
dc.subjectPAD12
dc.subject.meshNitric Oxideen
dc.subject.meshSmokingen
dc.subject.meshAsthmaen
dc.subject.meshRhinitisen
dc.subject.meshImmunoglobulin Een
dc.subject.meshSkin Testsen
dc.subject.meshIcelanden
dc.titleExhaled nitric oxide in a middle-aged Icelandic population cohort.en
dc.typearticleen
dc.contributor.departmentPrimary Hlth Care Ctr, Gardabaer, Iceland [ 2 ] Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 3 ] Univ Iceland, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 4 ] Uppsala Univ, Dept Med Sci, Clin Physiol, S-75236 Uppsala, Sweden Show the Organization-Enhanced name(s) [ 5 ] Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, S-75236 Uppsala, Swedenen
dc.identifier.journalJournal of breath researchen
dc.rights.accessClosed - Lokaðen
html.description.abstractThe prevalence of atopy and asthma is relatively low in Iceland. The purpose of this study was to describe exhaled nitric oxide (FeNO) levels in the general population in correlation with demographic characteristics, smoking status, asthma, rhinitis, atopic status and lung function tests. Altogether 403 subjects, from the European Community Respiratory Health Survey (ECRHS) III who answered the main questionnaire and were checked by FeNO measurements, lung function testing, skin prick testing and measurement of total IgE and specific IgE were included. The geometric mean (95% CI) of FeNO was 16.2 ppb (15.2-17.1) and the prevalence of higher FeNO (⩾25 ppb) was 19.5% in the random sample. Subjects with higher FeNO levels were less likely to be current smokers and more likely to have asthma and rhinitis. Having higher FeNO values was also associated with higher total IgE, having specific IgE to at least one allergen and being skin prick test positive. Current smokers had significantly lower levels of FeNO, geometric mean (95% CI) 9.6 ppb (8.4-11.0), than ex-smokers 18.2 ppb (16.6-20.0) and never smokers 17.3 ppb (16.1-18.5). In multivariable models, having asthma (OR (95% CI) 2.10 (1.20-3.67)), having a specific IgE (OR 2.30 (1.25-4.23)) and being skin prick test positive (OR 2.06 (1.18-3.60)) were independently positively associated with a higher FeNO (⩾25) whereas current smoking was independently negatively associated with a higher FeNO (OR 0.19 (0.06-0.63)). Higher levels of FeNO (⩾25 ppb) were found in one out of five Icelanders; FeNO was positively associated with asthma and allergy and negatively with smoking.


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