Genetics of cardiovascular diseases: lessons learned from a decade of genomics research in Iceland.
dc.contributor.author | Arnar, David O | |
dc.contributor.author | Andersen, Karl | |
dc.contributor.author | Thorgeirsson, Gudmundur | |
dc.date.accessioned | 2017-01-30T15:30:32Z | |
dc.date.available | 2017-01-30T15:30:32Z | |
dc.date.issued | 2016 | |
dc.date.submitted | 2017 | |
dc.identifier.citation | Genetics of cardiovascular diseases: lessons learned from a decade of genomics research in Iceland., 50 (5-6):260-265 Scand. Cardiovasc. J. | en |
dc.identifier.issn | 1651-2006 | |
dc.identifier.pmid | 27572422 | |
dc.identifier.doi | 10.1080/14017431.2016.1230679 | |
dc.identifier.uri | http://hdl.handle.net/2336/620102 | |
dc.description | Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/Open To access publisher's full text version of this article click on the hyperlink at the bottom of the page | en |
dc.description.abstract | In the past 10 years, large-scale genotyping has led to discoveries of sequence variants that confer the risk of many common and complex diseases. Due to pioneering work done, in large part, at deCODE genetics in Reykjavik, discoveries from Iceland have contributed substantially to key advances in population genetics. In cardiovascular medicine, a number of discoveries have been made, uncovering sequence variants that are associated with disorders such as coronary artery disease, atrial fibrillation, sick sinus syndrome, peripheral vascular disease, aortic aneurysm, and ischemic stroke. Thus, a wealth of genetic data has been accumulated in cardiology and has enhanced our understanding of a number of diseases. In many cases, these findings offer new mechanistic clues into the pathophysiology of complex cardiovascular diseases and may point toward novel therapeutic approaches in drug therapy. The next important step is to begin to transform these findings into practical clinical knowledge with the aim of improving the delivery of cardiovascular health care. | |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.relation.url | http://www.tandfonline.com/doi/pdf/10.1080/14017431.2016.1230679?needAccess=true | en |
dc.rights | Archived with thanks to Scandinavian cardiovascular journal : SCJ | en |
dc.subject | Blóðrásarsjúkdómar | en |
dc.subject | Arfgengi | en |
dc.subject | Erfðafræði | en |
dc.subject | CAR12 | |
dc.subject.mesh | Genetics | en |
dc.subject.mesh | Atrial Fibrillation | en |
dc.subject.mesh | Coronary Artery Disease | en |
dc.subject.mesh | Genome-Wide Association Study | en |
dc.subject.mesh | Precision Medicine | en |
dc.subject.mesh | Sick Sinus Syndrome | en |
dc.subject.mesh | Iceland | en |
dc.title | Genetics of cardiovascular diseases: lessons learned from a decade of genomics research in Iceland. | en |
dc.type | Article | en |
dc.contributor.department | [ 1 ] Landspitali, Div Cardiol, Dept Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 2 ] Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland [ 3 ] deCODE Genet, Reykjavik, Iceland | en |
dc.identifier.journal | Scandinavian cardiovascular journal : SCJ | en |
dc.rights.access | Closed - Lokað | en |
html.description.abstract | In the past 10 years, large-scale genotyping has led to discoveries of sequence variants that confer the risk of many common and complex diseases. Due to pioneering work done, in large part, at deCODE genetics in Reykjavik, discoveries from Iceland have contributed substantially to key advances in population genetics. In cardiovascular medicine, a number of discoveries have been made, uncovering sequence variants that are associated with disorders such as coronary artery disease, atrial fibrillation, sick sinus syndrome, peripheral vascular disease, aortic aneurysm, and ischemic stroke. Thus, a wealth of genetic data has been accumulated in cardiology and has enhanced our understanding of a number of diseases. In many cases, these findings offer new mechanistic clues into the pathophysiology of complex cardiovascular diseases and may point toward novel therapeutic approaches in drug therapy. The next important step is to begin to transform these findings into practical clinical knowledge with the aim of improving the delivery of cardiovascular health care. |