Primary aldosteronism: from case detection to histopathology with up to 6 years of follow-up.
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Issue Date
2016-11-23
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Primary aldosteronism: from case detection to histopathology with up to 6 years of follow-up. 2016 J Clin Hypertens (Greenwich)Journal of Clinical Hypertension 2017,19(4):424-430
Abstract
The authors aimed to investigate the clinical characteristics, accuracy of diagnostic tests, and long-term outcomes after interventions in patients diagnosed with primary aldosteronism (PA) in Iceland throughout 5 years. A retrospective chart review was performed for all patients diagnosed with PA during the years 2007-2011 at Landspitali Hospital in Iceland, a referral center for the whole country. Workup after detection included salt loading test, positional test, computed tomography, and adrenal vein sampling. Patients with unilateral disease were offered treatment with adrenalectomy. A total of 33 patients were diagnosed with PA during the study period: 17 patients with bilateral disease and 16 with unilateral disease. Results from salt loading test were positive in 90% of patients. In patients with adenoma, 36% were responsive on their positional test and computed tomography scan showed a nodule in 73%. All patients with unilateral disease had a lateralization index ≥3. After surgery, patients had lower systolic blood pressure (P<.001) and number of hypertensive medications (P<.01).Description
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Archived with thanks to Journal of clinical hypertension (Greenwich, Conn.)ae974a485f413a2113503eed53cd6c53
10.1111/jch.12947
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