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dc.contributor.authorMelvinsdottir, Inga H
dc.contributor.authorLund, Sigrun H
dc.contributor.authorAgnarsson, Bjarni A
dc.contributor.authorSigvaldason, Kristinn
dc.contributor.authorGudbjartsson, Tomas
dc.contributor.authorGeirsson, Arnar
dc.date.accessioned2017-03-27T12:42:04Z
dc.date.available2017-03-27T12:42:04Z
dc.date.issued2016-12
dc.date.submitted2017
dc.identifier.citationThe incidence and mortality of acute thoracic aortic dissection: results from a whole nation study. 2016, 50 (6):1111-1117 Eur J Cardiothorac Surgen
dc.identifier.issn1873-734X
dc.identifier.pmid27334108
dc.identifier.doi10.1093/ejcts/ezw235
dc.identifier.urihttp://hdl.handle.net/2336/620124
dc.descriptionNeðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenTo access publisher's full text version of this article click on the hyperlink at the bottom of the pageen
dc.description.abstractAcute thoracic aortic dissection (ATAD) is a devastating condition associated with a high mortality rate. Recent reports suggest that its incidence is rising. Utilizing nationwide data comprising the whole Icelandic population, we aimed to determine the incidence, mortality rate and time-dependent mortality risk of ATAD.
dc.description.abstractData were retrospectively collected using centralized hospital discharge registries, autopsy records and Cause of Death Registry in Iceland from 1992 to 2013.
dc.description.abstractAge- and gender-adjusted incidence of ATAD was 2.53/100 000/year, and no significant change in incidence was observed during the study period. The mean age was 66.9 ± 13.6 years and 66.0% (101/153) were Stanford type A. Of the whole group, 17.6% (27/153) died prior to hospital arrival, whereas the risk of death for patients who arrived alive to a hospital was 21.4% (27/126) within 24 h and 45.2% (57/126) at 30 days. During the course of the study, patients with type A dissection were more likely to undergo an operation and the management of type B dissection changed from open to endovascular repair. The 30-day mortality rate declined every year and the 5-year survival rate improved in the last third of the study.
dc.description.abstractThe incidence of ATAD was 2.53/100 000/year and remained constant throughout the study, contradicting recent perceptions of a rising incidence. ATAD, type A in particular, remains a highly lethal condition: Over half of all patients die within 30 days of the index event. A reduced 30-day mortality rate and an increased long-term survival rate indicate improved overall outcomes in patients with this complex condition.
dc.description.sponsorshipLandspitali University Hospital Scientific Fund University of Iceland Research Funden
dc.language.isoenen
dc.publisherOXFORD UNIV PRESS INCen
dc.relation.urlhttps://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ejcts/50/6/10.1093_ejcts_ezw235/2/ezw235.pdf?Expires=1490957648&Signature=ZPy7uIoLyT~iSBqrhbjGvtGKSOgOOeOCT7RBfm-v9FzdLntkMHdMLGhJJ9QAH~tuUf3OmGIUdmwQb-WG58xN8gbTiqI38yVnS1mET~hQHV969-RnpO4U546EKRVv~2D1SOAalbgAHGuGf-v1QcvalIfsE-3UcIYpfueycN-lg3lmOwOyEIrz6L5BjXKycRdLP5KkhmH9XvzmJg1a8A40DPU6dGKBC5HRGOHD8Qodz8GVySai2UpcdWvVoLtYhj3Iy97NdA1Ggfr2yUAL4otZSVK-5DztkF5gmK~v2ZhRVIhiMs6xMpYsyr2FWAqOvSP-K1wTL-2pYd1jrJ7W1Gd5QA__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Qen
dc.rightsArchived with thanks to European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgeryen
dc.subjectÆðasjúkdómaren
dc.subjectÆðaskurðlækningaren
dc.subjectPTT12en
dc.subjectAAA12en
dc.subjectTAS12en
dc.subject.meshAortic Aneurysm, Thoracicen
dc.subject.meshAortic Ruptureen
dc.titleThe incidence and mortality of acute thoracic aortic dissection: results from a whole nation study.en
dc.typeArticleen
dc.contributor.department[ 1 ] Landspitali Univ Hosp, Dept Cardiothorac Surg, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital Show the Organization-Enhanced name(s) [ 2 ] Univ Iceland, Fac Med, Reykjavik, Iceland Hide the Organization-Enhanced name(s) [ 3 ] Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital Hide the Organization-Enhanced name(s) [ 4 ] Landspitali Univ Hosp, Dept Anesthesiol, Reykjavik, Iceland Organization-Enhanced Name(s) Landspitali National University Hospital Show the Organization-Enhanced name(s) [ 5 ] Yale Univ, Sch Med, Sect Cardiac Surg, New Haven, CT USA [ 6 ] Vet Affairs Connecticut Healthcare Syst, Dept Surg, West Haven, CT USAen
dc.identifier.journalEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgeryen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractAcute thoracic aortic dissection (ATAD) is a devastating condition associated with a high mortality rate. Recent reports suggest that its incidence is rising. Utilizing nationwide data comprising the whole Icelandic population, we aimed to determine the incidence, mortality rate and time-dependent mortality risk of ATAD.
html.description.abstractData were retrospectively collected using centralized hospital discharge registries, autopsy records and Cause of Death Registry in Iceland from 1992 to 2013.
html.description.abstractAge- and gender-adjusted incidence of ATAD was 2.53/100 000/year, and no significant change in incidence was observed during the study period. The mean age was 66.9 ± 13.6 years and 66.0% (101/153) were Stanford type A. Of the whole group, 17.6% (27/153) died prior to hospital arrival, whereas the risk of death for patients who arrived alive to a hospital was 21.4% (27/126) within 24 h and 45.2% (57/126) at 30 days. During the course of the study, patients with type A dissection were more likely to undergo an operation and the management of type B dissection changed from open to endovascular repair. The 30-day mortality rate declined every year and the 5-year survival rate improved in the last third of the study.
html.description.abstractThe incidence of ATAD was 2.53/100 000/year and remained constant throughout the study, contradicting recent perceptions of a rising incidence. ATAD, type A in particular, remains a highly lethal condition: Over half of all patients die within 30 days of the index event. A reduced 30-day mortality rate and an increased long-term survival rate indicate improved overall outcomes in patients with this complex condition.


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