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A genome-wide association study yields five novel thyroid cancer risk loci.

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Authors
Gudmundsson, Julius
Thorleifsson, Gudmar
Sigurdsson, Jon K
Stefansdottir, Lilja
Jonasson, Jon G
Gudjonsson, Sigurjon A
Gudbjartsson, Daniel F
Masson, Gisli
Johannsdottir, Hrefna
Halldorsson, Gisli H
Stacey, Simon N
Helgason, Hannes
Sulem, Patrick
Senter, Leigha
He, Huiling
Liyanarachchi, Sandya
Ringel, Matthew D
Aguillo, Esperanza
Panadero, Angeles
Prats, Enrique
Garcia-Castaño, Almudena
De Juan, Ana
Rivera, Fernando
Xu, Li
Kiemeney, Lambertus A
Eyjolfsson, Gudmundur I
Sigurdardottir, Olof
Olafsson, Isleifur
Kristvinsson, Hoskuldur
Netea-Maier, Romana T
Jonsson, Thorvaldur
Mayordomo, Jose I
Plantinga, Theo S
Hjartarson, Hannes
Hrafnkelsson, Jon
Sturgis, Erich M
Thorsteinsdottir, Unnur
Rafnar, Thorunn
de la Chapelle, Albert
Stefansson, Kari
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Issue Date
2017-02-14

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Citation
A genome-wide association study yields five novel thyroid cancer risk loci. 2017, 8:14517 Nat Commun
Abstract
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10(-8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10(-7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.
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Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316879/pdf/ncomms14517.pdf
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Archived with thanks to Nature communications
ae974a485f413a2113503eed53cd6c53
10.1038/ncomms14517
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English Journal Articles (Peer Reviewed)

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