A genome-wide association study yields five novel thyroid cancer risk loci.
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Sigurdsson, Jon K
Jonasson, Jon G
Gudjonsson, Sigurjon A
Gudbjartsson, Daniel F
Halldorsson, Gisli H
Stacey, Simon N
Ringel, Matthew D
De Juan, Ana
Kiemeney, Lambertus A
Eyjolfsson, Gudmundur I
Netea-Maier, Romana T
Mayordomo, Jose I
Plantinga, Theo S
Sturgis, Erich M
de la Chapelle, Albert
MetadataShow full item record
CitationA genome-wide association study yields five novel thyroid cancer risk loci. 2017, 8:14517 Nat Commun
AbstractThe great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10(-8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10(-7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.
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