A genome-wide association study yields five novel thyroid cancer risk loci.
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Authors
Gudmundsson, JuliusThorleifsson, Gudmar
Sigurdsson, Jon K
Stefansdottir, Lilja
Jonasson, Jon G
Gudjonsson, Sigurjon A
Gudbjartsson, Daniel F
Masson, Gisli
Johannsdottir, Hrefna
Halldorsson, Gisli H
Stacey, Simon N
Helgason, Hannes
Sulem, Patrick
Senter, Leigha
He, Huiling
Liyanarachchi, Sandya
Ringel, Matthew D
Aguillo, Esperanza
Panadero, Angeles
Prats, Enrique
Garcia-Castaño, Almudena
De Juan, Ana
Rivera, Fernando
Xu, Li
Kiemeney, Lambertus A
Eyjolfsson, Gudmundur I
Sigurdardottir, Olof
Olafsson, Isleifur
Kristvinsson, Hoskuldur
Netea-Maier, Romana T
Jonsson, Thorvaldur
Mayordomo, Jose I
Plantinga, Theo S
Hjartarson, Hannes
Hrafnkelsson, Jon
Sturgis, Erich M
Thorsteinsdottir, Unnur
Rafnar, Thorunn
de la Chapelle, Albert
Stefansson, Kari
Issue Date
2017-02-14
Metadata
Show full item recordCitation
A genome-wide association study yields five novel thyroid cancer risk loci. 2017, 8:14517 Nat CommunAbstract
The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with Pcombined<3 × 10(-8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR=1.20, P=3.2 × 10(-7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.Description
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Archived with thanks to Nature communicationsae974a485f413a2113503eed53cd6c53
10.1038/ncomms14517
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