Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Walters, G Bragi
Olafsson, Ingvar H
Karlsson, Karl O
Frigge, Michael L
Magnusson, Olafur T
Thorgeirsson, Thorgeir E
MetadataShow full item record
CitationSequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation. 2017, 8:14265 Nat Commun
AbstractLumbar disc herniation (LDH) is common and often debilitating. Microdiscectomy of herniated lumbar discs (LDHsurg) is performed on the most severe cases to resolve the resulting sciatica. Here we perform a genome-wide association study on 4,748 LDHsurg cases and 282,590 population controls and discover 37 highly correlated markers associating with LDHsurg at 8q24.21 (between CCDC26 and GSDMC), represented by rs6651255[C] (OR=0.81; P=5.6 × 10(-12)) with a stronger effect among younger patients than older. As rs6651255[C] also associates with height, we performed a Mendelian randomization analysis using height polygenic risk scores as instruments to estimate the effect of height on LDHsurg risk, and found that the marker's association with LDHsurg is much greater than predicted by its effect on height. In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.
DescriptionEfst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files
RightsArchived with thanks to Nature communications
- Familial predisposition for lumbar degenerative disc disease. A case-control study.
- Authors: Matsui H, Kanamori M, Ishihara H, Yudoh K, Naruse Y, Tsuji H
- Issue date: 1998 May 1
- Synchronous lumbar disc herniation in adult twins. Case report.
- Authors: Bhardwaj R, Midha R
- Issue date: 2004 Nov
- The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation.
- Authors: Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Rygh LJ, Røe C, Gjerstad J
- Issue date: 2012 Aug
- Preoperative retrolisthesis as a risk factor of postdecompression lumbar disc herniation.
- Authors: Takenaka S, Tateishi K, Hosono N, Mukai Y, Fuji T
- Issue date: 2016 Apr
- The MMP1 rs1799750 2G allele is associated with increased low back pain, sciatica, and disability after lumbar disk herniation.
- Authors: Jacobsen LM, Schistad EI, Storesund A, Pedersen LM, Espeland A, Rygh LJ, Røe C, Gjerstad J
- Issue date: 2013 Nov