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dc.contributor.authorThorleifsdottir, Ragna Hlin
dc.contributor.authorSigurdardottir, Sigrun Laufey
dc.contributor.authorSigurgeirsson, Bardur
dc.contributor.authorOlafsson, Jón Hjaltalin
dc.contributor.authorSigurdsson, Martin Ingi
dc.contributor.authorPetersen, Hannes
dc.contributor.authorGudjonsson, Johann Eli
dc.contributor.authorJohnston, Andrew
dc.contributor.authorValdimarsson, Helgi
dc.date.accessioned2017-05-12T12:55:50Z
dc.date.available2017-05-12T12:55:50Z
dc.date.issued2017-03-10
dc.date.submitted2017
dc.identifier.citationPatient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial. 2017, 97 (3):340-345 Acta Derm. Venereol.en
dc.identifier.issn1651-2057
dc.identifier.pmid27819714
dc.identifier.doi10.2340/00015555-2562
dc.identifier.urihttp://hdl.handle.net/2336/620183
dc.descriptionEfst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinnen
dc.description.abstractPsoriasis is a chronic inflammatory skin disease with profound effects on patients' health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psoriasis Disability Index, Psoriasis Life Stress Inventory and Psoriasis Area and Severity Index. HRQoL and psoriasis-related stress improved significantly in the tonsillectomy group compared with the control group (p = 0.037 and p = 0.002, respectively), with a mean 50% improvement in HRQoL and a mean 59% improvement in psoriasis-induced stress. Clinical improvement correlated significantly with improved HRQoL (r = 0.297, p = 0.008) and psoriasis-related stress (r = 0.310, p = 0.005). Of the tonsillectomized patients, 87% concluded that the procedure was worthwhile. Tonsillectomy may improve quality of life for selected patients with plaque psoriasis.
dc.description.sponsorshipIcelandic Research Fund Landspitali University Hospital Research Fund NIH National Psoriasis Foundation USA Babcock Memorial Trust A. Alfred Taubman Medical Research Institute as the Kenneth and Frances Eisenberg Emerging Scholar Award Doris Duke Charitable Foundationen
dc.language.isoenen
dc.publisherActa Dermato-Venereologicaen
dc.relation.urlhttps://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-2562en
dc.rightsArchived with thanks to Acta dermato-venereologicaen
dc.subjectSóríasisen
dc.subjectHálskirtlaren
dc.subjectAAI12en
dc.subjectAAA12en
dc.subjectOTO12en
dc.subject.meshAdulten
dc.subject.meshCost of Illnessen
dc.subject.meshDisability Evaluationen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIcelanden
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPatient Reported Outcome Measuresen
dc.subject.meshPsoriasisen
dc.subject.meshQuality of Lifeen
dc.subject.meshRemission Inductionen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshTime Factorsen
dc.subject.meshTonsillectomyen
dc.subject.meshTreatment Outcomeen
dc.titlePatient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial.en
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Iceland, Dermatol Sect, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 2 ] Uppsala Univ, Dept Med Sci, Dermatol, Uppsala, Sweden [ 3 ] Landspitali Natl Univ Hosp Iceland, Dept Immunol, Reykjavik, Iceland [ 4 ] Landspitali Natl Univ Hosp Iceland, Dept Anesthesiol & Crit Care, Reykjavik, Iceland [ 5 ] Landspitali Natl Univ Hosp Iceland, Dept Otolaryngol Head & Neck Surg, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 6 ] Univ Michigan, Sch Med, Dept Dermatol, Ann Arbor, MI USAen
dc.identifier.journalActa dermato-venereologicaen
dc.rights.accessOpen Access - Opinn aðganguren
refterms.dateFOA2018-09-12T16:35:24Z
html.description.abstractPsoriasis is a chronic inflammatory skin disease with profound effects on patients' health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psoriasis Disability Index, Psoriasis Life Stress Inventory and Psoriasis Area and Severity Index. HRQoL and psoriasis-related stress improved significantly in the tonsillectomy group compared with the control group (p = 0.037 and p = 0.002, respectively), with a mean 50% improvement in HRQoL and a mean 59% improvement in psoriasis-induced stress. Clinical improvement correlated significantly with improved HRQoL (r = 0.297, p = 0.008) and psoriasis-related stress (r = 0.310, p = 0.005). Of the tonsillectomized patients, 87% concluded that the procedure was worthwhile. Tonsillectomy may improve quality of life for selected patients with plaque psoriasis.


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