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dc.contributor.authorMagnusson, Skuli
dc.contributor.authorBaldursson, Baldur Tumi
dc.contributor.authorKjartansson, Hilmar
dc.contributor.authorRolfsson, Ottar
dc.contributor.authorSigurjonsson, Gudmundur Fertram
dc.date.accessioned2017-05-15T09:45:57Z
dc.date.available2017-05-15T09:45:57Z
dc.date.issued2017-03
dc.date.submitted2017
dc.identifier.citationRegenerative and Antibacterial Properties of Acellular Fish Skin Grafts and Human Amnion/Chorion Membrane: Implications for Tissue Preservation in Combat Casualty Care. 2017, 182 (S1):383-388 Mil Meden
dc.identifier.issn1930-613X
dc.identifier.pmid28291503
dc.identifier.doi10.7205/MILMED-D-16-00142
dc.identifier.urihttp://hdl.handle.net/2336/620185
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractImprovised explosive devices and new directed energy weapons are changing warfare injuries from penetrating wounds to large surface area thermal and blast injuries. Acellular fish skin is used for tissue repair and during manufacturing subjected to gentle processing compared to biologic materials derived from mammals. This is due to the absence of viral and prion disease transmission risk, preserving natural structure and composition of the fish skin graft.
dc.description.abstractThe aim of this study was to assess properties of acellular fish skin relevant for severe battlefield injuries and to compare those properties with those of dehydrated human amnion/chorion membrane.
dc.description.abstractWe evaluated cell ingrowth capabilities of the biological materials with microscopy techniques. Bacterial barrier properties were tested with a 2-chamber model.
dc.description.abstractThe microstructure of the acellular fish skin is highly porous, whereas the microstructure of dehydrated human amnion/chorion membrane is mostly nonporous. The fish skin grafts show superior ability to support 3-dimensional ingrowth of cells compared to dehydrated human amnion/chorion membrane (p < 0.0001) and the fish skin is a bacterial barrier for 24 to 48 hours.
dc.description.abstractThe unique biomechanical properties of the acellular fish skin graft make it ideal to be used as a conformal cover for severe trauma and burn wounds in the battlefield.
dc.description.sponsorshipOffice of Naval Research and Kerecis Limited, Eyrargata,Isafjordur, Icelanden
dc.language.isoenen
dc.publisherAssociation of Military Surgeonsen
dc.relation.urlhttp://web.a.ebscohost.com/ehost/results?sid=44806424-7574-405d-8886-f15ae485cb15%40sessionmgr4007&vid=0&hid=4209&bquery=(SO+(Military+Medicine))AND(DT+2017)AND(TI+regenerative+and+antibacterial+properties+of+acellular+fish+skin+grafts+and+human+amnion%2fchorion+membrane)&bdata=JmRiPWFwaCZ0eXBlPTEmc2l0ZT1laG9zdC1saXZlen
dc.rightsArchived with thanks to Military medicineen
dc.subjectSáragræðslaen
dc.subjectFiskroðen
dc.subjectEAM12en
dc.subjectDAV12en
dc.subject.meshWound Healingen
dc.subject.meshFishesen
dc.subject.meshSkin, Artificialen
dc.titleRegenerative and Antibacterial Properties of Acellular Fish Skin Grafts and Human Amnion/Chorion Membrane: Implications for Tissue Preservation in Combat Casualty Care.en
dc.typeArticleen
dc.contributor.department[ 1 ] Kerecis Ltd, Eyrargata 2, IS-400 Isafjordur, Iceland Show the Organization-Enhanced name(s) [ 2 ] Univ Iceland, Ctr Syst Biol, Sturlugata 8, IS-101 Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 3 ] Natl Univ Hosp Iceland, IS-101 Reykjavik, Icelanden
dc.identifier.journalMilitary medicineen
dc.rights.accessNational Consortium - Landsaðganguren
html.description.abstractImprovised explosive devices and new directed energy weapons are changing warfare injuries from penetrating wounds to large surface area thermal and blast injuries. Acellular fish skin is used for tissue repair and during manufacturing subjected to gentle processing compared to biologic materials derived from mammals. This is due to the absence of viral and prion disease transmission risk, preserving natural structure and composition of the fish skin graft.
html.description.abstractThe aim of this study was to assess properties of acellular fish skin relevant for severe battlefield injuries and to compare those properties with those of dehydrated human amnion/chorion membrane.
html.description.abstractWe evaluated cell ingrowth capabilities of the biological materials with microscopy techniques. Bacterial barrier properties were tested with a 2-chamber model.
html.description.abstractThe microstructure of the acellular fish skin is highly porous, whereas the microstructure of dehydrated human amnion/chorion membrane is mostly nonporous. The fish skin grafts show superior ability to support 3-dimensional ingrowth of cells compared to dehydrated human amnion/chorion membrane (p < 0.0001) and the fish skin is a bacterial barrier for 24 to 48 hours.
html.description.abstractThe unique biomechanical properties of the acellular fish skin graft make it ideal to be used as a conformal cover for severe trauma and burn wounds in the battlefield.


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