Show simple item record

dc.contributor.authorSpauwen, Peggy J J
dc.contributor.authorMurphy, Rachel A
dc.contributor.authorJónsson, Pálmi V
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorGarcia, Melissa E
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorvan Boxtel, Martin P J
dc.contributor.authorLopez, Oscar L
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHarris, Tamara B
dc.contributor.authorLauner, Lenore J
dc.date.accessioned2017-05-15T15:23:35Z
dc.date.available2017-05-15T15:23:35Z
dc.date.issued2017-03-01
dc.date.submitted2017
dc.identifier.citationAssociations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study. 2017, 46 (2):250-257 Age Ageingen
dc.identifier.issn1468-2834
dc.identifier.pmid28399220
dc.identifier.doi10.1093/ageing/afw219
dc.identifier.urihttp://hdl.handle.net/2336/620188
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractstudies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life.
dc.description.abstractwe studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykjavik Study of whom 485 (9.4%) were diagnosed with mild cognitive impairment (MCI) and 307 (5.9%) with dementia. Visceral fat, abdominal and thigh subcutaneous fat, and thigh muscle were assessed by computed tomography. MCI and dementia were based on clinical assessment and a consensus meeting; those without MCI or dementia were categorised as normal. Multinomial regression models assessed the associations stratified by sex and in additional analyses by midlife body mass index (BMI).
dc.description.abstractamong women, there was a decreased likelihood of dementia per SD increase in abdominal subcutaneous fat (OR 0.72; 95% CI: 0.59-0.88), thigh subcutaneous fat (0.81; 0.67-0.98) and thigh muscle (0.63; 0.52-0.76), but not visceral fat, adjusting for demographics, vascular risk factors, stroke and depression. Inverse associations of fat with dementia were attenuated by weight change from midlife and were strongest in women with midlife BMI <25. In men, one SD increase in thigh muscle was associated with a decreased likelihood of dementia (0.75; 0.61-0.92). BC was not associated with MCI in men or women.
dc.description.abstracta higher amount of abdominal and thigh subcutaneous fat were associated with a lower likelihood of dementia in women only, while more thigh muscle was associated with a lower likelihood of dementia in men and women.
dc.description.sponsorshipNational Institutes of Health National Institute on Aging Intramural Research Program 'Hjartavernd' (the Icelandic Heart Association) 'Althingi' (the Icelandic Parliament) Internationale Stichting Alzheimer Onderzoeken
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttps://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ageing/46/2/10.1093_ageing_afw219/2/afw219.pdf?Expires=1494954847&Signature=cVNWDx-oi9dipOi1MJksHp72OW6XhRVBKXbMqvV9gjCwPpmQ4~212CZOGeXYwa4SpRkN4o2tcjrzMe8VxBD0VEmgj3imwt3nfikwDjb4Nb1ztp3ppRyVHTmv5HYG5aP8RkduL69XE728PqBdoByysqDi3mLxvqYxTJZFmYzSl3SAwTMcvYajeuC-u5q7AhzidC2LaAqLpmODy1JTIAJJhkP-4BYOKOAmpwbGzUtVzlQzKFMMi6KEUM7M3be4PycKesiJwo0GHSO7HYEdfmYVTpUEXC0YuBNxXoAEG635ib8V1of-Z5LSx8VHmOaPN2g0Jyjr7FCBbhLLBOOrmkYIDA__&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Qen
dc.rightsArchived with thanks to Age and ageingen
dc.subjectHoldafaren
dc.subjectAldraðiren
dc.subjectElliglöpen
dc.subjectGER12en
dc.subject.meshBody Compositionen
dc.subject.meshAgeden
dc.subject.meshAged, 80 and overen
dc.subject.meshDementiaen
dc.titleAssociations of fat and muscle tissue with cognitive status in older adults: the AGES-Reykjavik Study.en
dc.typeArticleen
dc.contributor.department1 Department of Psychiatry and Neuropsychology, Maastricht University Medical Center and School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands. 2 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA. 3 Department of Geriatrics, Landspitali National University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 4 Icelandic Heart Association Research Institute, Kopavogur, Iceland. 5 Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.en
dc.identifier.journalAge and ageingen
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractstudies on the association of dementia with specific body composition (BC) components are scarce. Our aim was to investigate associations of BC measures with different levels of cognitive function in late-life.
html.description.abstractwe studied 5,169 participants (mean age 76 years, 42.9% men) in the AGES-Reykjavik Study of whom 485 (9.4%) were diagnosed with mild cognitive impairment (MCI) and 307 (5.9%) with dementia. Visceral fat, abdominal and thigh subcutaneous fat, and thigh muscle were assessed by computed tomography. MCI and dementia were based on clinical assessment and a consensus meeting; those without MCI or dementia were categorised as normal. Multinomial regression models assessed the associations stratified by sex and in additional analyses by midlife body mass index (BMI).
html.description.abstractamong women, there was a decreased likelihood of dementia per SD increase in abdominal subcutaneous fat (OR 0.72; 95% CI: 0.59-0.88), thigh subcutaneous fat (0.81; 0.67-0.98) and thigh muscle (0.63; 0.52-0.76), but not visceral fat, adjusting for demographics, vascular risk factors, stroke and depression. Inverse associations of fat with dementia were attenuated by weight change from midlife and were strongest in women with midlife BMI <25. In men, one SD increase in thigh muscle was associated with a decreased likelihood of dementia (0.75; 0.61-0.92). BC was not associated with MCI in men or women.
html.description.abstracta higher amount of abdominal and thigh subcutaneous fat were associated with a lower likelihood of dementia in women only, while more thigh muscle was associated with a lower likelihood of dementia in men and women.


This item appears in the following Collection(s)

Show simple item record