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dc.contributor.authorRenault, K M
dc.contributor.authorCarlsen, E M
dc.contributor.authorHædersdal, S
dc.contributor.authorNilas, L
dc.contributor.authorSecher, N J
dc.contributor.authorEugen-Olsen, J
dc.contributor.authorCortes, D
dc.contributor.authorOlsen, S F
dc.contributor.authorHalldorsson, T I
dc.contributor.authorNørgaard, K
dc.date.accessioned2017-07-04T14:00:11Z
dc.date.available2017-07-04T14:00:11Z
dc.date.issued2017-04
dc.date.submitted2017
dc.identifier.citationImpact of lifestyle intervention for obese women during pregnancy on maternal metabolic and inflammatory markers. 2017, 41 (4):598-605 Int J Obes (Lond)en
dc.identifier.issn1476-5497
dc.identifier.pmid28093573
dc.identifier.doi10.1038/ijo.2017.9
dc.identifier.urihttp://hdl.handle.net/2336/620249
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractOffspring of obese mothers have increased risk of developing obesity and related short- and long-term disease. The cause is multifactorial and may partly be explained by the unfavorable intrauterine environment. Intervention during pregnancy leading to a healthier lifestyle among obese may alter this.
dc.description.abstractTo assess the effect of lifestyle intervention on markers of maternal metabolism and inflammation in 'the TOP (Treatment of Obese Pregnant Women) study', a randomized controlled trial.
dc.description.abstractIn the TOP-study 425 participants with body mass index ⩾30 kg/m(2) were randomized to intervention with dietary advices and physical activity assessed by pedometer (PA+D), physical activity assessed by pedometer (PA) or control (C). Of 389 participants completing the study 376 had available blood samples. Serum was analyzed for insulin, c-peptide, lipid profile, leptin, high-sensitivity CRP (hsCRP) and Soluble urokinase Plasminogen Activator Receptor (suPAR), in week 18-20 and 28-30, and simultaneously a 2-h oral glucose-tolerance-test was performed. Diet was assessed in gestational week 11-14 and 36-37 using a validated 360-item Food Frequency Questionnaire.
dc.description.abstractMedian levels of hsCRP in gestational week 28-30 were lower in each of the intervention groups (8.3 mg/l in PA+D group, P=0.03; and 8.8 mg/l in PA group, P=0.02) versus the control group (11.5 mg/l). Obtaining 11 000 steps per day as aimed for resulted in a 21% lower hsCRP compared to non-compliant women. Women reporting high carbohydrate intake had around 30% higher hsCRP concentrations in late gestation than women reporting the lowest intake. There were no differences in lipid profile or any of the metabolic markers in gestational week 28-30 when comparing the intervention and control groups.
dc.description.abstractLifestyle intervention in obese women can reduce hsCRP representing a marker of inflammation during pregnancy. The effect may partly be mediated by more physical activity and partly by changes in intake of carbohydrates and the glycaemic load.
dc.description.sponsorshipSygekassernes Helsefond Brodrene Hartmann Fonden Danish Council for Strategic Researchen
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.relation.urlhttps://www.nature.com/ijo/journal/v41/n4/pdf/ijo20179a.pdfen
dc.rightsArchived with thanks to International journal of obesity (2005)en
dc.subjectLífshættiren
dc.subjectMeðferðen
dc.subjectMeðgangaen
dc.subjectBarnshafandi konuren
dc.subjectOffitaen
dc.subjectEfnaskiptasjúkdómaren
dc.subjectNUR12en
dc.subject.meshHealthy Lifestyleen
dc.subject.meshPregnancyen
dc.subject.meshObesityen
dc.subject.meshMetabolismen
dc.titleImpact of lifestyle intervention for obese women during pregnancy on maternal metabolic and inflammatory markers.en
dc.typeArticleen
dc.contributor.department1 Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. 2 Obstetric Clinic, JMC, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 3 Department of Pediatrics, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. 4 Center for Diabetes Research, Copenhagen University Hospital Gentofte, Hellerup, Denmark. 5 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. 6 The Research Unit Women's and Children's Health, the Juliane Marie Centre, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. 7 Clinical Research Centre, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. 8 Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. 9 Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. 10 Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. 11 Unit for Nutrition Research, Landspitali University Hospital, Reykjavik, Iceland. 12 Department of Endocrinology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.en
dc.identifier.journalInternational journal of obesity (2005)en
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractOffspring of obese mothers have increased risk of developing obesity and related short- and long-term disease. The cause is multifactorial and may partly be explained by the unfavorable intrauterine environment. Intervention during pregnancy leading to a healthier lifestyle among obese may alter this.
html.description.abstractTo assess the effect of lifestyle intervention on markers of maternal metabolism and inflammation in 'the TOP (Treatment of Obese Pregnant Women) study', a randomized controlled trial.
html.description.abstractIn the TOP-study 425 participants with body mass index ⩾30 kg/m(2) were randomized to intervention with dietary advices and physical activity assessed by pedometer (PA+D), physical activity assessed by pedometer (PA) or control (C). Of 389 participants completing the study 376 had available blood samples. Serum was analyzed for insulin, c-peptide, lipid profile, leptin, high-sensitivity CRP (hsCRP) and Soluble urokinase Plasminogen Activator Receptor (suPAR), in week 18-20 and 28-30, and simultaneously a 2-h oral glucose-tolerance-test was performed. Diet was assessed in gestational week 11-14 and 36-37 using a validated 360-item Food Frequency Questionnaire.
html.description.abstractMedian levels of hsCRP in gestational week 28-30 were lower in each of the intervention groups (8.3 mg/l in PA+D group, P=0.03; and 8.8 mg/l in PA group, P=0.02) versus the control group (11.5 mg/l). Obtaining 11 000 steps per day as aimed for resulted in a 21% lower hsCRP compared to non-compliant women. Women reporting high carbohydrate intake had around 30% higher hsCRP concentrations in late gestation than women reporting the lowest intake. There were no differences in lipid profile or any of the metabolic markers in gestational week 28-30 when comparing the intervention and control groups.
html.description.abstractLifestyle intervention in obese women can reduce hsCRP representing a marker of inflammation during pregnancy. The effect may partly be mediated by more physical activity and partly by changes in intake of carbohydrates and the glycaemic load.


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