Reproductive fitness and genetic risk of psychiatric disorders in the general population.
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Authors
Mullins, NiamhIngason, Andrés
Porter, Heather
Euesden, Jack
Gillett, Alexandra
Ólafsson, Sigurgeir
Gudbjartsson, Daniel F
Lewis, Cathryn M
Sigurdsson, Engilbert
Saemundsen, Evald
Gudmundsson, Ólafur Ó
Frigge, Michael L
Kong, Augustine
Helgason, Agnar
Walters, G Bragi
Gustafsson, Omar
Stefansson, Hreinn
Stefansson, Kari
Issue Date
2017-06-13
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Reproductive fitness and genetic risk of psychiatric disorders in the general population. 2017, 8:15833 Nat CommunAbstract
The persistence of common, heritable psychiatric disorders that reduce reproductive fitness is an evolutionary paradox. Here, we investigate the selection pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, major depression and attention deficit hyperactivity disorder (ADHD) using genomic data from 150,656 Icelanders, excluding those diagnosed with these psychiatric diseases. Polygenic risk of autism and ADHD is associated with number of children. Higher polygenic risk of autism is associated with fewer children and older age at first child whereas higher polygenic risk of ADHD is associated with having more children. We find no evidence for a selective advantage of a high polygenic risk of schizophrenia or bipolar disorder. Rare copy-number variants conferring moderate to high risk of psychiatric illness are associated with having fewer children and are under stronger negative selection pressure than common sequence variants.Description
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Archived with thanks to Nature communicationsae974a485f413a2113503eed53cd6c53
10.1038/ncomms15833
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