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dc.contributor.authorKern, Helmut
dc.contributor.authorHofer, Cristian
dc.contributor.authorLoefler, Stefan
dc.contributor.authorZampieri, Sandra
dc.contributor.authorGargiulo, Paolo
dc.contributor.authorBaba, Alfonc
dc.contributor.authorMarcante, Andrea
dc.contributor.authorPiccione, Francesco
dc.contributor.authorPond, Amber
dc.contributor.authorCarraro, Ugo
dc.date.accessioned2017-08-11T11:06:16Z
dc.date.available2017-08-11T11:06:16Z
dc.date.issued2017-07
dc.date.submitted2017
dc.identifier.citationAtrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Aging. Implications for their recovery by Functional Electrical Stimulation, updated 2017. 2017, 39 (7):660-666 Neurol. Res.en
dc.identifier.issn1743-1328
dc.identifier.pmid28403681
dc.identifier.doi10.1080/01616412.2017.1314906
dc.identifier.urihttp://hdl.handle.net/2336/620262
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractLong-term lower motor neuron denervation of skeletal muscle is known to result in degeneration of muscle with replacement by adipose and fibrotic tissues. However, long-term survival of a subset of skeletal myofibers also occurs.
dc.description.abstractWe performed transverse and longitudinal studies of patients with spinal cord injury (SCI), patients specifically complete Conus and Cauda Equina Syndrome and also of active and sedentary seniors which included analyses of muscle biopsies from the quadriceps m.
dc.description.abstractSurprisingly, we discovered that human denervated myofibers survive years of denervation after full and irreversible disconnection from their motor neurons. We found that atrophic myofibers could be rescued by home-based Functional Electrical Stimulation (h-bFES), using purpose developed stimulators and electrodes. Although denervated myofibers quickly lose the ability to sustain high-frequency contractions, they respond to very long impulses that are able to allow for re-emergence of tetanic contractions. A description of the early muscle changes in humans are hampered by a paucity of patients suffering complete Conus and Cauda Equina Syndrome, but the cohort enrolled in the EU RISE Project has shown that even five years after SCI, severe atrophic myofibers with a peculiar cluster reorganization of myonuclei are present in human muscles and respond to h-bFES.
dc.description.abstractHuman myofibers survive permanent denervation longer than generally accepted and they respond to h-bFES beyond the stage of simple atrophy. Furthermore, long-term denervation/reinnervation events occur in elderly people and are part of the mechanisms responsible for muscle aging and again h-bFES was beneficial in delaying aging decay.
dc.description.sponsorshipEuropean Regional Development Fund-Cross Border Cooperation Program SLOVAKIA-AUSTRIA (Interreg-Iva) project 'Mobilitat im Alter' Austrian Federal Ministry of Science and Research Ludwig Boltzmann Society (Vienna)en
dc.language.isoenen
dc.publisherTaylor & Francisen
dc.relation.urlhttp://www.tandfonline.com/doi/full/10.1080/01616412.2017.1314906?scroll=top&needAccess=trueen
dc.rightsArchived with thanks to Neurological researchen
dc.subjectTaugafrumuren
dc.subjectTaugaboðen
dc.subjectVöðvahreyfingaren
dc.subjectVöðvaren
dc.subjectRafstraumuren
dc.subjectRES12en
dc.subject.meshElectric Stimulation Therapyen
dc.subject.meshMotor Neuronsen
dc.subject.meshMuscle Denervationen
dc.subject.meshSpinal Cord Injuriesen
dc.subject.meshAgeden
dc.titleAtrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Aging. Implications for their recovery by Functional Electrical Stimulation, updated 2017.en
dc.typeArticleen
dc.contributor.department1 a Physiko- und Rheumatherapie , St. Poelten , Austria. 2 b Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation , Vienna , Austria. 3 c Department of Biomedical Sciences , University of Padova , Padova , Italy. 4 d Instutute for Biomedical and Neural Engineering/Biomedical Technology Centre , Reykjavik University and Landspitali , Reykjavik , Iceland. 5 e IRCCS Fondazione Ospedale San Camillo , Venice , Italy. 6 f Anatomy Department , Southern Illinois University School of Medicine , Carbondale , IL , USA.en
dc.identifier.journalNeurological researchen
dc.rights.accessClosed - Lokaðen
html.description.abstractLong-term lower motor neuron denervation of skeletal muscle is known to result in degeneration of muscle with replacement by adipose and fibrotic tissues. However, long-term survival of a subset of skeletal myofibers also occurs.
html.description.abstractWe performed transverse and longitudinal studies of patients with spinal cord injury (SCI), patients specifically complete Conus and Cauda Equina Syndrome and also of active and sedentary seniors which included analyses of muscle biopsies from the quadriceps m.
html.description.abstractSurprisingly, we discovered that human denervated myofibers survive years of denervation after full and irreversible disconnection from their motor neurons. We found that atrophic myofibers could be rescued by home-based Functional Electrical Stimulation (h-bFES), using purpose developed stimulators and electrodes. Although denervated myofibers quickly lose the ability to sustain high-frequency contractions, they respond to very long impulses that are able to allow for re-emergence of tetanic contractions. A description of the early muscle changes in humans are hampered by a paucity of patients suffering complete Conus and Cauda Equina Syndrome, but the cohort enrolled in the EU RISE Project has shown that even five years after SCI, severe atrophic myofibers with a peculiar cluster reorganization of myonuclei are present in human muscles and respond to h-bFES.
html.description.abstractHuman myofibers survive permanent denervation longer than generally accepted and they respond to h-bFES beyond the stage of simple atrophy. Furthermore, long-term denervation/reinnervation events occur in elderly people and are part of the mechanisms responsible for muscle aging and again h-bFES was beneficial in delaying aging decay.


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