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Formulations and toxicologic in vivo studies of aqueous cyclosporin A eye drops with cyclodextrin nanoparticles.

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Authors
Jóhannsdóttir, Sunna
Kristinsson, Johannes K
Fülöp, Zoltán
Ásgrímsdóttir, Gudrún
Stefánsson, Einar
Loftsson, Thorsteinn
Issue Date
2017-08-30

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Formulations and toxicologic in vivo studies of aqueous cyclosporin A eye drops with cyclodextrin nanoparticles. 2017, 529 (1-2):486-490 Int J Pharm
Abstract
Cyclosporin A (CyA) is an immunosuppressive drug used topically to treat ocular inflammatory disorder such as dry eye disease (DES). It is a lipophilic cyclic peptide with molecular weight of 1202.6Da. The aim of this study was to develop surfactant free aqueous 0.2% (w/v) CyA eye drops where the drug is present in an aqueous vehicle containing CyA/cyclodextrin (CyA/CD) nanoparticles and then do three-month toxicological testing in rabbits. Five formulations of different CD concentrations were studied, all of them contained 12.5% (w/v) of α-cyclodextrin (αCD) and various amounts of γ-cyclodextrin (γCD) (ranging from 0 to 12.5% w/v). αCD was used to solubilize the drug and γCD to promote formation of complex aggregates. CyA/CD complex aggregates were formed in all the formulations tested. However, the formulation containing 12.5% (w/v) αCD and 12.5% (w/v) γCD created more CyA/CD nanoparticles of suitable size and was therefore tested in vivo. The eye drops did not cause ocular irritation or toxic side effects upon topical administration to rabbits once or twice a day for three months.
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https://ac.els-cdn.com/S0378517317306439/1-s2.0-S0378517317306439-main.pdf?_tid=d4ff21bc-9fa1-11e7-a775-00000aacb361&acdnat=1506090487_75f435e1176a531cd1c789db50bd26da
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Archived with thanks to International journal of pharmaceutics
ae974a485f413a2113503eed53cd6c53
10.1016/j.ijpharm.2017.07.044
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