The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsChoi, M Y
Clarke, A E
St Pierre, Y
Hanly, J G
Urowitz, M B
Wallace, D J
Merrill, J T
Isenberg, D A
Ginzler, E M
Bruce, I N
Dooley, M A
Gladman, D D
Khamashta, M A
Alarcón, G S
Zoma, A A
van Vollenhoven, R F
Lim, S S
Kalunian, K C
Kamen, D L
Peschken, C A
Fritzler, M J
MetadataShow full item record
CitationThe prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients. 2017, 26 (10):1051-1059 Lupus
AbstractAutoantibodies to dense fine speckles 70 (DFS70) are purported to rule out the diagnosis of SLE when they occur in the absence of other SLE-related autoantibodies. This study is the first to report the prevalence of anti-DFS70 in an early, multinational inception SLE cohort and examine demographic, clinical, and autoantibody associations. Patients were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort within 15 months of diagnosis. The association between anti-DFS70 and multiple parameters in 1137 patients was assessed using univariate and multivariate logistic regression. The frequency of anti-DFS70 was 7.1% (95% CI: 5.7-8.8%), while only 1.1% (95% CI: 0.6-1.9%) were monospecific for anti-DFS70. In multivariate analysis, patients with musculoskeletal activity (Odds Ratio (OR) 1.24 [95% CI: 1.10, 1.41]) or with anti-β2 glycoprotein 1 (OR 2.17 [95% CI: 1.22, 3.87]) were more likely and patients with anti-dsDNA (OR 0.53 [95% CI: 0.31, 0.92]) or anti-SSB/La (OR 0.25 [95% CI: 0.08, 0.81]) were less likely to have anti-DFS70. In this study, the prevalence of anti-DFS70 was higher than the range previously published for adult SLE (7.1 versus 0-2.8%) and was associated with musculoskeletal activity and anti-β2 glycoprotein 1 autoantibodies. However, 'monospecific' anti-DFS70 autoantibodies were rare (1.1%) and therefore may be helpful to discriminate between ANA-positive healthy individuals and SLE.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
RightsArchived with thanks to Lupus
- Anti-DFS70/LEDGF antibodies are more prevalent in healthy individuals compared to patients with systemic autoimmune rheumatic diseases.
- Authors: Mahler M, Parker T, Peebles CL, Andrade LE, Swart A, Carbone Y, Ferguson DJ, Villalta D, Bizzaro N, Hanly JG, Fritzler MJ
- Issue date: 2012 Nov
- Prevalence of anti-DFS70 autoantibodies in a Latin American cohort of patients with systemic lupus erythematosus and without autoimmune diseases.
- Authors: Aragón CC, Posso-Osorio I, Puerta G, González JD, Naranjo JC, Echeverri A, Ortíz E, Nieto-Aristizábal I, Barrera MC, Ríos-Serna LJ, Tobón GJ
- Issue date: 2020 Jul
- Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls.
- Authors: Schmeling H, Mahler M, Levy DM, Moore K, Stevens AM, Wick J, McMillan JD, Horneff G, Assassi S, Charles J, Salazar G, Mayes MD, Silverman ED, Klien-Gitelman M, Lee T, Brunner HI, Reed AM, Fritzler MJ
- Issue date: 2015 Dec
- Development and multi-center evaluation of a novel immunoadsorption method for anti-DFS70 antibodies.
- Authors: Bentow C, Rosenblum R, Correia P, Karayev E, Karayev D, Williams D, Kulczycka J, Fritzler MJ, Mahler M
- Issue date: 2016 Jul
- High concomitance of disease marker autoantibodies in anti-DFS70/LEDGF autoantibody-positive patients with autoimmune rheumatic disease.
- Authors: Muro Y, Sugiura K, Morita Y, Tomita Y
- Issue date: 2008 Mar