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dc.contributor.authorKim, Jinyoung
dc.contributor.authorMohler, Emile R.
dc.contributor.authorKeenan, Brendan T.
dc.contributor.authorMaislin, David
dc.contributor.authorArnardottir, Erna Sif
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorBenediktsdottir, Bryndis
dc.contributor.authorGudmundsdottir, Sigrun
dc.contributor.authorSifferman, Andrea
dc.contributor.authorStaley, Bethany
dc.contributor.authorPack, Frances M.
dc.contributor.authorMaislin, Greg
dc.contributor.authorChirinos, Julio A.
dc.contributor.authorPack, Allan I.
dc.contributor.authorKuna, Samuel T.
dc.date.accessioned2017-10-25T15:43:21Z
dc.date.available2017-10-25T15:43:21Z
dc.date.issued2017-07-27
dc.date.submitted2017
dc.identifier.citationCarotid Artery Wall Thickness in Obese and Non-obese Adults with Obstructive Sleep Apnea Before and Following Positive Airway Pressure Treatment 2017 Sleepen
dc.identifier.issn0161-8105
dc.identifier.issn1550-9109
dc.identifier.doi10.1093/sleep/zsx126
dc.identifier.urihttp://hdl.handle.net/2336/620325
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractSTUDY OBJECTIVES: Debate persists as to whether obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. The purpose of this study was to compare carotid intima-media thickness (IMT), an early sign of atherosclerosis, in obese and nonobese adults with OSA before and following positive airway pressure (PAP) treatment. METHODS: A total of 206 adults newly diagnosed with OSA with an apnea-hypopnea index (AHI) of 15-75 events/hour and 53 controls with AHI <10 were studied. Waist circumference was used to classify participants as obese and nonobese. Bilateral common carotid artery B-mode ultrasound was performed at baseline to assess IMT, arterial diameter, arterial-wall mass, and circumferential wall stress. Measurements were repeated in 118 participants with OSA who completed a 4-month PAP treatment and had an average daily use over that period of ≥4 hours/day. RESULTS: No significant differences in carotid IMT, diameter, or arterial-wall mass were present at baseline between participants with OSA and controls stratified by waist circumference, after adjusting for other cardiovascular risk factors. In participants with OSA, who had adequate PAP adherence over the 4-month treatment, carotid artery diameter significantly increased (mean change [95% confidence interval] = 0.13 [0.06, 0.20] mm; p = .0004), but no significant changes in carotid IMT, arterial-wall mass, and circumferential stress were observed in obese and nonobese participants. CONCLUSIONS: Regardless of obesity status, carotid IMT is not increased in adults with moderate to severe OSA versus controls and does not change following 4 months of PAP treatment.
dc.description.sponsorshipNational Institute of Healthen
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttps://academic.oup.com/sleep/article-lookup/doi/10.1093/sleep/zsx126en
dc.rightsArchived with thanks to Sleepen
dc.subjectÆðakölkunen
dc.subjectKæfisvefnen
dc.subjectPAD12en
dc.subjectNAF12en
dc.subject.meshAtherosclerosisen
dc.subject.meshSleep Apnea, Obstructiveen
dc.subject.meshPositive-Pressure Respirationen
dc.titleCarotid Artery Wall Thickness in Obese and Non-obese Adults with Obstructive Sleep Apnea Before and Following Positive Airway Pressure Treatmenten
dc.typeArticleen
dc.contributor.department[ 1 ] Univ Penn, Sch Nursing, 418 Curie Blvd, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) [ 2 ] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA [ 3 ] Univ Penn, Dept Med, Div Cardiovasc, Sect Vasc Med,Perelman Sch Med, Philadelphia, PA 19104 USA [ 4 ] Landspitali, Dept Resp Med & Sleep, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 5 ] Univ Iceland, Fac Med, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 6 ] Univ Penn, Div Sleep Med, Perelman Sch Med, Philadelphia, PA 19104 USA Show the Organization-Enhanced name(s) [ 7 ] Univ Penn, Dept Med, Renal Electrolyte & Hypertens Div, Perelman Sch Med, Philadelphia, PA 19104 USA [ 8 ] Corporal Michael J Crescenz Vet Affairs Med Ctr, Dept Med, Philadelphia, PA USAen
dc.identifier.journalSleepen
dc.rights.accessClosed - Lokaðen
html.description.abstractSTUDY OBJECTIVES: Debate persists as to whether obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. The purpose of this study was to compare carotid intima-media thickness (IMT), an early sign of atherosclerosis, in obese and nonobese adults with OSA before and following positive airway pressure (PAP) treatment. METHODS: A total of 206 adults newly diagnosed with OSA with an apnea-hypopnea index (AHI) of 15-75 events/hour and 53 controls with AHI <10 were studied. Waist circumference was used to classify participants as obese and nonobese. Bilateral common carotid artery B-mode ultrasound was performed at baseline to assess IMT, arterial diameter, arterial-wall mass, and circumferential wall stress. Measurements were repeated in 118 participants with OSA who completed a 4-month PAP treatment and had an average daily use over that period of ≥4 hours/day. RESULTS: No significant differences in carotid IMT, diameter, or arterial-wall mass were present at baseline between participants with OSA and controls stratified by waist circumference, after adjusting for other cardiovascular risk factors. In participants with OSA, who had adequate PAP adherence over the 4-month treatment, carotid artery diameter significantly increased (mean change [95% confidence interval] = 0.13 [0.06, 0.20] mm; p = .0004), but no significant changes in carotid IMT, arterial-wall mass, and circumferential stress were observed in obese and nonobese participants. CONCLUSIONS: Regardless of obesity status, carotid IMT is not increased in adults with moderate to severe OSA versus controls and does not change following 4 months of PAP treatment.


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