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dc.contributor.authorMarques, Elisa A
dc.contributor.authorElbejjani, Martine
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorSigurdsson, Gunnar
dc.contributor.authorLang, Thomas
dc.contributor.authorSigurdsson, Sigurdur
dc.contributor.authorAspelund, Thor
dc.contributor.authorMeirelles, Osorio
dc.contributor.authorSiggeirsdottir, Kristin
dc.contributor.authorLauner, Lenore
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorHarris, Tamara B
dc.date.accessioned2017-10-31T15:36:29Z
dc.date.available2017-10-31T15:36:29Z
dc.date.issued2017-06
dc.date.submitted2017
dc.identifier.citationProximal Femur Volumetric Bone Mineral Density and Mortality: 13 Years of Follow-Up of the AGES-Reykjavik Study. 2017, 32 (6):1237-1242 J. Bone Miner. Res.en
dc.identifier.issn1523-4681
dc.identifier.pmid28276125
dc.identifier.doi10.1002/jbmr.3104
dc.identifier.urihttp://hdl.handle.net/2336/620335
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractBone mineral density (BMD) has been linked to mortality, but little is known about the independent contribution of each endosteal bone compartment and also the rate of bone loss to risk of mortality. We examined the relationships between (1) baseline trabecular and cortical volumetric BMD (vBMD) at the proximal femur, and (2) the rate of trabecular and cortical bone loss and all-cause mortality in older adults from the AGES-Reykjavik study. The analysis of trabecular and cortical vBMD and mortality was based on the baseline cohort of 4654 participants (aged ≥66 years) with a median follow-up of 9.4 years; the association between rate of bone loss and mortality was based on 2653 participants with bone loss data (median follow-up of 5.6 years). Analyses employed multivariable Cox-proportional models to estimate hazard ratios (HRs) with time-varying fracture status; trabecular and cortical variables were included together in all models. Adjusted for important confounders, Cox models showed that participants in the lowest quartile of trabecular vBMD had an increased risk of mortality compared to participants in other quartiles (HR = 1.12; 95% confidence interval (CI), 1.01 to 1.25); baseline cortical vBMD was not related to mortality (HR = 1.08; 95% CI, 0.97 to 1.20). After adjustment for time-dependent fracture status, results were attenuated and not statistically significant. A faster loss (quartile 1 versus quartiles 2-4) in both trabecular and cortical bone was associated with higher mortality risk (HR = 1.37 and 1.33, respectively); these associations were independent of major potential confounders including time-dependent incident fractures (HR = 1.32 and 1.34, respectively). Overall, data suggest that faster bone losses over time in both the trabecular and cortical bone compartments are associated with mortality risk and that measurements of change in bone health may be more informative than single-point measurements in explaining mortality differences in older adults. © 2017 American Society for Bone and Mineral Research.
dc.description.sponsorshipNational Institutes of Health Hjartavernd (the Icelandic Heart Association) Althingi (the Icelandic Parliament) Intramural Research Program of the NIH, National Institute on Agingen
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jbmr.3104/pdfen
dc.rightsArchived with thanks to Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Researchen
dc.subjectBeinþynningen
dc.subjectBeinþéttnien
dc.subjectDánarmeinen
dc.subjectDánartíðnien
dc.subjectBeinþéttnimælingaren
dc.subjectEND12en
dc.subject.meshBone Resorptionen
dc.subject.meshBone Densityen
dc.subject.meshMortalityen
dc.titleProximal Femur Volumetric Bone Mineral Density and Mortality: 13 Years of Follow-Up of the AGES-Reykjavik Study.en
dc.typeArticleen
dc.contributor.department1 ] NIA, Intramural Res Program, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA [ 2 ] Iceland Heart Assoc Res Inst, Kopavogur, Iceland Show the Organization-Enhanced name(s) [ 3 ] Univ Iceland, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 4 ] Landspitali Univ Hosp, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 5 ] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA Show the Organization-Enhanced name(s) [ 6 ] Univ Iceland, Ctr Publ Hlth Sci, Reykjavik, Icelanden
dc.identifier.journalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Researchen
dc.rights.accessClosed - Lokaðen
html.description.abstractBone mineral density (BMD) has been linked to mortality, but little is known about the independent contribution of each endosteal bone compartment and also the rate of bone loss to risk of mortality. We examined the relationships between (1) baseline trabecular and cortical volumetric BMD (vBMD) at the proximal femur, and (2) the rate of trabecular and cortical bone loss and all-cause mortality in older adults from the AGES-Reykjavik study. The analysis of trabecular and cortical vBMD and mortality was based on the baseline cohort of 4654 participants (aged ≥66 years) with a median follow-up of 9.4 years; the association between rate of bone loss and mortality was based on 2653 participants with bone loss data (median follow-up of 5.6 years). Analyses employed multivariable Cox-proportional models to estimate hazard ratios (HRs) with time-varying fracture status; trabecular and cortical variables were included together in all models. Adjusted for important confounders, Cox models showed that participants in the lowest quartile of trabecular vBMD had an increased risk of mortality compared to participants in other quartiles (HR = 1.12; 95% confidence interval (CI), 1.01 to 1.25); baseline cortical vBMD was not related to mortality (HR = 1.08; 95% CI, 0.97 to 1.20). After adjustment for time-dependent fracture status, results were attenuated and not statistically significant. A faster loss (quartile 1 versus quartiles 2-4) in both trabecular and cortical bone was associated with higher mortality risk (HR = 1.37 and 1.33, respectively); these associations were independent of major potential confounders including time-dependent incident fractures (HR = 1.32 and 1.34, respectively). Overall, data suggest that faster bone losses over time in both the trabecular and cortical bone compartments are associated with mortality risk and that measurements of change in bone health may be more informative than single-point measurements in explaining mortality differences in older adults. © 2017 American Society for Bone and Mineral Research.


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