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dc.contributor.authorStøve, Heidi Kristine
dc.contributor.authorSandahl, Julie Damgaard
dc.contributor.authorAbrahamsson, Jonas
dc.contributor.authorAsdahl, Peter H
dc.contributor.authorForestier, Erik
dc.contributor.authorHa, Shau-Yin
dc.contributor.authorJahnukainen, Kirsi
dc.contributor.authorJónsson, Ólafur G
dc.contributor.authorLausen, Birgitte
dc.contributor.authorPalle, Josefine
dc.contributor.authorZeller, Bernward
dc.contributor.authorHasle, Henrik
dc.date.accessioned2017-11-16T15:44:29Z
dc.date.available2017-11-16T15:44:29Z
dc.date.issued2017-12
dc.date.submitted2017
dc.identifier.citationExtramedullary leukemia in children with acute myeloid leukemia: A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO). 2017, 64 (12) Pediatr Blood Canceren
dc.identifier.issn1545-5017
dc.identifier.pmid28333413
dc.identifier.doi10.1002/pbc.26520
dc.identifier.urihttp://hdl.handle.net/2336/620354
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractThe prognostic significance of extramedullary leukemia (EML) in childhood acute myeloid leukemia is not clarified.
dc.description.abstractThis population-based study included 315 children from the NOPHO-AML 2004 trial.
dc.description.abstractAt diagnosis, 73 (23%) patients had EML: 39 (12%) had myeloid sarcoma, 22 (7%) had central nervous system disease, and 12 (4%) had both. EML was associated with young age (median age: 2.6 years), a high white blood cell count (median: 40 × 10(9) /l), M5 morphology (40%), and 11q23/MLL (KMT2A) rearrangements (34%). No patient received involved field radiotherapy. Five-year event-free survival did not differ significantly between the EML and the non-EML patients (54% vs. 45%, P = 0.57), whereas 5-year overall survival (OS) was significantly lower in the EML group (64% vs. 73%, P = 0.04). The risk of induction death was significantly higher for EML patients (8% vs. 1%, P = 0.002). There was a trend toward a lower risk of relapse for EML patients (5-year cumulative incidence of relapse 33% vs. 49%, P = 0.16). Traumatic lumbar puncture did not adversely affect survival in this cohort.
dc.description.abstractEML was associated with increased risk of induction death impacting the OS. No patients relapsed at the primary site of the myeloid sarcoma despite management without radiotherapy.
dc.description.sponsorshipDanish Cancer Society Department of Clinical Medicine at Aarhus University Danish Childhood Cancer Foundation Swedish Childhood Cancer Foundationen
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/pbc.26520/epdfen
dc.rightsArchived with thanks to Pediatric blood & canceren
dc.subjectBráðahvítblæðien
dc.subjectHvítblæðien
dc.subjectBörnen
dc.subjectPED12en
dc.subject.meshLeukemia, Myeloid, Acuteen
dc.subject.meshSarcoma, Myeloiden
dc.subject.meshChilden
dc.titleExtramedullary leukemia in children with acute myeloid leukemia: A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO).en
dc.typeArticleen
dc.contributor.department[ 1 ] Aarhus Univ Hosp, Dept Pediat, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark [ 2 ] Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden Show the Organization-Enhanced name(s) [ 3 ] Umea Univ Hosp, Dept Med Biosci & Genet, Umea, Sweden Show the Organization-Enhanced name(s) [ 4 ] Queen Mary Hosp, Hong Kong Pediat Hematol & Oncol Study Grp, Dept Pediat, Hong Kong, Hong Kong, Peoples R China Show the Organization-Enhanced name(s) [ 5 ] Univ Helsinki, Childrens Hosp, Helsinki, Finland Show the Organization-Enhanced name(s) [ 6 ] Helsinki Univ Hosp, Helsinki, Finland [ 7 ] Landspitalinn, Dept Pediat, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 8 ] Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark Show the Organization-Enhanced name(s) [ 9 ] Uppsala Univ, Dept Womans & Childrens Hlth, Uppsala, Sweden Show the Organization-Enhanced name(s) [ 10 ] Oslo Univ Hosp, Dept Pediat Med, Oslo, Norwayen
dc.identifier.journalPediatric blood & canceren
dc.rights.accessLandspitali Access - LSH-aðganguren
html.description.abstractThe prognostic significance of extramedullary leukemia (EML) in childhood acute myeloid leukemia is not clarified.
html.description.abstractThis population-based study included 315 children from the NOPHO-AML 2004 trial.
html.description.abstractAt diagnosis, 73 (23%) patients had EML: 39 (12%) had myeloid sarcoma, 22 (7%) had central nervous system disease, and 12 (4%) had both. EML was associated with young age (median age: 2.6 years), a high white blood cell count (median: 40 × 10(9) /l), M5 morphology (40%), and 11q23/MLL (KMT2A) rearrangements (34%). No patient received involved field radiotherapy. Five-year event-free survival did not differ significantly between the EML and the non-EML patients (54% vs. 45%, P = 0.57), whereas 5-year overall survival (OS) was significantly lower in the EML group (64% vs. 73%, P = 0.04). The risk of induction death was significantly higher for EML patients (8% vs. 1%, P = 0.002). There was a trend toward a lower risk of relapse for EML patients (5-year cumulative incidence of relapse 33% vs. 49%, P = 0.16). Traumatic lumbar puncture did not adversely affect survival in this cohort.
html.description.abstractEML was associated with increased risk of induction death impacting the OS. No patients relapsed at the primary site of the myeloid sarcoma despite management without radiotherapy.


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