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dc.contributor.authorZhu, Yeyi
dc.contributor.authorOlsen, Sjurdur F
dc.contributor.authorMendola, Pauline
dc.contributor.authorHalldorsson, Thorhallur I
dc.contributor.authorRawal, Shristi
dc.contributor.authorHinkle, Stefanie N
dc.contributor.authorYeung, Edwina H
dc.contributor.authorChavarro, Jorge E
dc.contributor.authorGrunnet, Louise G
dc.contributor.authorGranström, Charlotta
dc.contributor.authorBjerregaard, Anne A
dc.contributor.authorHu, Frank B
dc.contributor.authorZhang, Cuilin
dc.date.accessioned2017-11-23T14:58:00Z
dc.date.available2017-11-23T14:58:00Z
dc.date.issued2017-10
dc.date.submitted2017
dc.identifier.citationMaternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort study 2017, 46 (5):1499 International Journal of Epidemiologyen
dc.identifier.issn0300-5771
dc.identifier.issn1464-3685
dc.identifier.doi10.1093/ije/dyx095
dc.identifier.urihttp://hdl.handle.net/2336/620360
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen
dc.description.abstractBACKGROUND: Artificial sweeteners are widely replacing caloric sweeteners. Data on long-term impact of artificially sweetened beverage (ASB) consumption during pregnancy on offspring obesity risk are lacking. We prospectively investigated intake of ASBs and sugar-sweetened beverages (SSBs) during pregnancy in relation to offspring growth through age 7 years among high-risk children born to women with gestational diabetes. METHODS: In a prospective study of 918 mother-singleton child dyads from the Danish National Birth Cohort, maternal dietary intake was assessed by a food frequency questionnaire during pregnancy. Offspring body mass index z-scores (BMIZ) and overweight/obesity status were derived using weight and length/height at birth, 5 and 12 months and 7 years. Linear regression and Poisson regression with robust standard errors were used, adjusting for major risk factors. RESULTS: Approximately half of women reported consuming ASBs during pregnancy and 9% consumed daily. Compared to never consumption, daily ASB intake during pregnancy was positively associated with offspring large-for-gestational age [adjusted relative risk (aRR) 1.57; 95% CI: 1.05, 2.35 at birth], BMIZ (adjusted β 0.59; 95% CI: 0.23, 0.96) and overweight/obesity (aRR 1.93; 95% CI; 1.24, 3.01) at 7 years. Per-serving-per-day substitution of ASBs with water during pregnancy was related to a lower overweight/obesity risk at 7 years (aRR 0.83; 95% CI: 0.76, 0.91), whereas SSB substitution with ASBs was not related to a lower risk (aRR 1.14; 95% CI: 1.00, 1.31). CONCLUSIONS: Our findings illustrated positive associations between intrauterine exposure to ASBs and birth size and risk of overweight/obesity at 7 years. Data with longer follow-up are warranted.
dc.description.sponsorshipIntramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Danish Research Councilen
dc.language.isoenen
dc.publisherOxford University Pressen
dc.relation.urlhttp://academic.oup.com/ije/article/46/5/1499/3861466en
dc.rightsArchived with thanks to International Journal of Epidemiologyen
dc.subjectSætuefnien
dc.subjectDrykkiren
dc.subjectGosdrykkiren
dc.subjectMeðgangaen
dc.subjectOffitaen
dc.subjectNUR12en
dc.subject.meshNon-Nutritive Sweetenersen
dc.subject.meshBeveragesen
dc.subject.meshPregnancyen
dc.subject.meshObesityen
dc.titleMaternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort studyen
dc.typeArticleen
dc.contributor.department[ 1 ] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, 6710 Rockledge Dr, Bethesda, MD 20819 USA Show the Organization-Enhanced name(s) [ 2 ] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA [ 3 ] Statens Serum Inst, Ctr Fetal Programming, Copenhagen, Denmark Show the Organization-Enhanced name(s) [ 4 ] Landspitali Univ Hosp, Unit Nutr Res, Reykjavik, Iceland Show the Organization-Enhanced name(s) [ 5 ] Univ Iceland, Fac Food Sci & Nutr, Reykjavik, Iceland [ 6 ] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA [ 7 ] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA [ 8 ] Rigshosp Univ Hosp, Dept Endocrinol, Copenhagen, Denmarken
dc.identifier.journalInternational Journal of Epidemiologyen
dc.rights.accessClosed - Lokaðen
html.description.abstractBACKGROUND: Artificial sweeteners are widely replacing caloric sweeteners. Data on long-term impact of artificially sweetened beverage (ASB) consumption during pregnancy on offspring obesity risk are lacking. We prospectively investigated intake of ASBs and sugar-sweetened beverages (SSBs) during pregnancy in relation to offspring growth through age 7 years among high-risk children born to women with gestational diabetes. METHODS: In a prospective study of 918 mother-singleton child dyads from the Danish National Birth Cohort, maternal dietary intake was assessed by a food frequency questionnaire during pregnancy. Offspring body mass index z-scores (BMIZ) and overweight/obesity status were derived using weight and length/height at birth, 5 and 12 months and 7 years. Linear regression and Poisson regression with robust standard errors were used, adjusting for major risk factors. RESULTS: Approximately half of women reported consuming ASBs during pregnancy and 9% consumed daily. Compared to never consumption, daily ASB intake during pregnancy was positively associated with offspring large-for-gestational age [adjusted relative risk (aRR) 1.57; 95% CI: 1.05, 2.35 at birth], BMIZ (adjusted β 0.59; 95% CI: 0.23, 0.96) and overweight/obesity (aRR 1.93; 95% CI; 1.24, 3.01) at 7 years. Per-serving-per-day substitution of ASBs with water during pregnancy was related to a lower overweight/obesity risk at 7 years (aRR 0.83; 95% CI: 0.76, 0.91), whereas SSB substitution with ASBs was not related to a lower risk (aRR 1.14; 95% CI: 1.00, 1.31). CONCLUSIONS: Our findings illustrated positive associations between intrauterine exposure to ASBs and birth size and risk of overweight/obesity at 7 years. Data with longer follow-up are warranted.


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