Evaluation of phenytoin serum levels following a loading dose in the acute hospital setting
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Authors
Selioutski, OlgaGrzesik, Katherine
Vasilyeva, Olga N.
Hilmarsson, Ágúst
Fessler, A. James
Liu, Lynn
Gross, Robert A.
Útgáfudagur
2017-11
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Evaluation of phenytoin serum levels following a loading dose in the acute hospital setting 2017, 52:199 SeizureÚtdráttur
PURPOSE: Due to the complex pharmacokinetic profiles of phenytoin (PHT) and fosphenytoin (FOS), achieving sustained, targeted serum PHT levels in the first day of use is challenging. METHODS: A population based approach was used to analyze total serum PHT (tPHT) level within 2-24h of PHT/FOS loading with or without supplementary maintenance or additional loading doses among PHT-naïve patients in the acute hospital setting. Adequate tPHT serum level was defined as ≥20μg/mL. RESULTS: Among 494 patients with 545 tPHT serum levels obtained in the first 2-24h after the loading dose (LD), tPHT serum levels of eitherLu00FDsing
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10.1016/j.seizure.2017.10.006
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