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dc.contributor.authorJarvis, Debbie
dc.contributor.authorNewson, Roger
dc.contributor.authorJanson, Christer
dc.contributor.authorCorsico, Angelo
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorAnto, Josep M
dc.contributor.authorAbramson, Michael J
dc.contributor.authorKirsten, Anne-Marie
dc.contributor.authorZock, Jan Paul
dc.contributor.authorBono, Roberto
dc.contributor.authorDemoly, Pascal
dc.contributor.authorLeynaert, Bénédicte
dc.contributor.authorRaherison, Chantal
dc.contributor.authorPin, Isabelle
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorJogi, Rain
dc.contributor.authorSchlunssen, Vivi
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorWatkins, John
dc.contributor.authorWeyler, Joost
dc.contributor.authorPereira-Vega, Antonio
dc.contributor.authorUrrutia, Isabel
dc.contributor.authorGullón, Jose A
dc.contributor.authorForsberg, Bertil
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorBoezen, H Marike
dc.contributor.authorMartinez-Moratalla Rovira, Jesús
dc.contributor.authorAccordini, Simone
dc.contributor.authorde Marco, Roberto
dc.contributor.authorBurney, Peter
dc.date.accessioned2018-01-31T11:06:01Z
dc.date.available2018-01-31T11:06:01Z
dc.date.issued2018-01
dc.date.submitted2018
dc.identifier.citationPrevalence of asthma-like symptoms with ageing 2018, 73 (1):37 Thoraxen
dc.identifier.issn0040-6376
dc.identifier.issn1468-3296
dc.identifier.doi10.1136/thoraxjnl-2016-209596
dc.identifier.urihttp://hdl.handle.net/2336/620439
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Filesen
dc.description.abstractBACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy. METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates. FINDINGS: Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to 1.11; 3.6%, 95% CI 3.0 to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline. INTERPRETATION: European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.
dc.description.sponsorshipEuropean Commission Asthma Foundation of Victoria Allen and Hanbury's Belgian Science Policy Office National Fund for Scientific Research Aarhus Estonian Science Foundation Ministere de la Sante Glaxo France Insitut Pneumologique d'Aquitaine Contrat de Plan Etat-Region Languedoc-Rousillon Ministre delegue de la sante RNSP, France GSF Bundes minister fur Forschung und Technologie Greek Secretary General of Research and Technology Fisons Astra Boehringer-Ingelheim Ministero dell'Universita e della Ricerca Scientifica e Tecnologica CNR Regione Veneto grant RSF Netherlands Dutch Ministry of Wellbeing, Public Health and Culture Netherlands Asthma Foundation Norwegian Research Council Glaxo Farmaceutica Lda, Sandoz Portugesa Fondo de Investigacion Sanitaria Hospital General de Albacete Hospital General Juan Ramon Jimenez Direccion Regional de Salud Publica (Consejeria de Sanidad del Principado de Asturias) CIRIT Servicio Andaluz de Salud Swedish Medical Research Council Swedish Heart Lung Foundation Swedish Association against Asthma and Allergy Swiss National Science Foundation National Asthma Campaign British Lung Foundation Department of Health South Thames Regional Health Authority National Health and Medical Research Council Antwerp: Fund for Scientific Research University of Antwerp Flemish Health Ministry Tartu Estonian Science Foundation Programme Hospitalier de Recherche Clinique-Direction de la Recherche Clinique (DRC) de Grenoble Ministry of Health Ministere de l'Emploi et de la Solidarite Direction Generale de la Sante Centre Hospitalier Universitaire (CHU) de Grenoble Institut Pneumologique d'Aquitaine Comite des Maladies Respiratoires de l'Isere Montpellier: Aventis (France) Direction Regionale des Affaires Sanitaires et Sociales Languedoc-Roussillon Union Chimique Belge-Pharma (France) Aventis (France) Erfurt GSF-National Research Centre for Environment and Health Deutsche Forschungsgemeinschaft GSF-National Research Centre for Environment and Health Reykjavik, Icelandic Research Council Icelandic University Hospital Fund Pavia GlaxoSmithKline Italy Italian Ministry of University and Scientific and Technological Research (MURST) Local University Funding for Research Azienda Sanitaria Locale 4 Regione Piemonte (Italy) Azienda Ospedaliera Centro Traumatologico Ospedaliero/Centro Traumatologico Ortopedico-Istituto Clinico Ortopedico Regina Maria Adelaide Regione Piemonte Verona: Ministero dell'Universita e della Ricerca Scientifica (MURST) Glaxo Wellcome SPA Bergen: Norwegian Research Council Norwegian Asthma and Allergy Association Glaxo Wellcome AS Norway Research Fund Fondo de Investigacion Santarias Hospital Universitario de Albacete Consejeria de Sanidad Sociedad Espanola de Neumologia y Cirugia Toracica Public Health Service Huelva: Fondo de Investigaciones Santarias Consell Interdepartamentalde Recerca i Innovacio Tecnologica Instituto de Salud Carlos II Red de Centros de Epidemiologia y Salud Publica Red de Bases moleculares y fisiologicas de las Enfermedades Respiratorias Red de Grupos Infancia y Medio Ambiente Basque Health Department Oviedo: Fondo de Investigaciones Sanitaria European Commission Generalitat de Catalunya Swedish Foundation for Health Care Sciences and Allergy Research Swedish Asthma and Allergy Foundation Swedish Cancer and Allergy Foundation Swedish Council for Working Life and Social Research (FAS) Basel Swiss National Science Foundation Swiss Federal Office for Education and Science Swiss National Accident Insurance Fund Asthma UK Medical Research Council Research Foundation Flanders (FWO) Estonian Ministry of Education Programme Hospitalier de Recherche Clinique (PHRC) INSERM U897 Universite Bordeaux Segalen Comite Scientifique AGIR adom Agence Nationale de la Sante, Region Ile de France, domaine d'interet majeur (DIM) Erfurt: German Research Foundation Reykjavik, The Landspitali University Hospital Research Fund University of Iceland Research Fund ResMed Foundation, California, USA Orkuveita Reykjavikur (Geothermal plant) Vegageroin (The Icelandic Road Administration, ICERA) Italian Ministry of Health Chiesi Farmaceutici SpA Cariverona Foundation, Education Ministry (MIUR) Western Norway Regional Health Authorities Bergen Medical Research Foundation Sociedad Espanola de Neumologia y Cirurgia Toracica Swedish Heart and Lung Foundation Swedish Asthma and Allergy Association Swedish Association against Lung and Heart Disease Swedish Research Council for Health, Working Life and Welfare (FORTE) Swedish Council for Working Life and Social Research Vasterbotten Country Council ALF grant Federal Office for Forest, Environment and Landscape Federal Office of Public Health Federal Office of Roads and Transport Canton's Government of Aargan Canton's Government of Basel-Stadt Canton's Government of Basel-Land Canton's Government of Geneva Canton's Government of Luzern Canton's Government of Ticino Canton's Government of Valais Canton's Government of Zurich Swiss Lung League Canton's Lung League of Basel Stadt/Basel Canton's Lung League of Landschaft Canton's Lung League of Geneva Canton's Lung League of Ticino Canton's Lung League of Valais Canton's Lung League of Zurich SUVA Freiwillige Akademische Gesellschaft UBS Wealth Foundation Talecris Biotherapeutics GmbH Abbott Diagnostics Wellcome Trust National Institute for Health Research through the Primary Care Research Network Sociedad Espanola de Neumologia y Cirugia Toracica Hamburg: German Research Foundation Barcelona: Fondo de Investigacion Sanitaria Galdakao: Fondo de Investigacion Sanitaria Huelva: Fondo de Investigacion Sanitaria Oviedo: Fondo de Investigacion Sanitariaen
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.relation.urlhttp://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2016-209596en
dc.rightsArchived with thanks to Thoraxen
dc.subjectAsmaen
dc.subjectAldraðiren
dc.subjectFaraldsfræðien
dc.subjectSjúkdómseinkennien
dc.subjectPAD12en
dc.subject.meshAsthmaen
dc.subject.meshEpidemiologyen
dc.subject.meshAgeden
dc.titlePrevalence of asthma-like symptoms with ageingen
dc.typeArticleen
dc.contributor.department[ 1 ] Imperial Coll, Natl Heart & Lung Inst, Populat Hlth & Occupat Dis, Emmanuel Kaye Bldg, London SW3 6LR, England Show more [ 2 ] Imperial Coll London, PHE Ctr Environm & Hlth, MRC, London, England Show more [ 3 ] Imperial Coll London, Dept Primary Care & Publ Hlth, London, England [ 4 ] Uppsala Univ, Dept Med Sci Resp Allergy & Sleep Res, Uppsala, Sweden Show more [ 5 ] Univ Pavia, Div Resp Dis, Dept Internal Med & Therapeut, IRCCS,Policlin San Matteo Fdn, Pavia, Italy Show more [ 6 ] Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, German Ctr Lung Res, Comprehens Pneumol Ctr Munich,Clin Ctr, Munich, Germany Show more [ 7 ] ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain Show more [ 8 ] Univ Pompeu Fabra, Barcelona, Spain Show more [ 9 ] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain [ 10 ] Inst Municipal Invest Med, Barcelona, Spain Show more [ 11 ] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia [ 12 ] Pulm Res Inst Lung Clin Grosshansdorf, Grosshansdorf, Germany Show more [ 13 ] Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy Show more [ 14 ] Univ Hosp Montpellier, Montpellier, France [ 15 ] Sorbonne Univ, Paris, France Show more [ 16 ] Univ Paris Diderot, INSERM, UMR 1152, Equipe Epidemiol, Paris, France Show more [ 17 ] Bordeaux Univ, INSERM, Bordeaux Populat Hlth Res Ctr, U1219, Bordeaux, France Show more [ 18 ] INSERM, IAB, Team Environm Epidemiol Appl Reprod & Resp Hlth, Grenoble, France Show more [ 19 ] CHU Grenoble Alpes, Dept Pediat, Grenoble, France Show more [ 20 ] Natl Univ Hosp Iceland, Dept Resp Med & Sleep Landspitali, Reykjavik, Iceland Show more [ 21 ] Univ Iceland, Fac Med, Reykjavik, Iceland [ 22 ] Tartu Univ Hosp, Lung Clin, Tartu, Estonia Show more [ 23 ] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark [ 24 ] Natl Res Ctr Working Environm, Copenhagen, Denmark Show more [ 25 ] Univ Bergen, Ctr Int Hlth, Bergen, Norway Show more [ 26 ] Haukeland Hosp, Dept Occupat Med, Bergen, Norway [ 27 ] Publ Hlth Wales, Cardiff, S Glam, Wales Show more [ 28 ] Univ Cardiff, Cardiff, S Glam, Wales Show more [ 29 ] Univ Antwerp, StatUA Stat Ctr, Fac Med & Hlth Sci, Dept Epidemiol & Social Med ESOC, Antwerp, Belgium [ 30 ] Univ Hosp Complex, Resp & Allergy Clin Unit, Huelva, Spain [ 31 ] Galdakao Hosp, Dept Resp, Galdakao, Spain [ 32 ] Hosp Univ San Agustin, Serv Neumol, Aviles, Spain Show more [ 33 ] Univ Umea, Publ Hlth & Clin Med Occupat & Environm Med, Umea, Sweden Show more [ 34 ] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland Show more [ 35 ] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands Show more [ 36 ] Complejo Hosp Univ, Serv Neumol, Albacete, Spain Show more [ 37 ] Univ Castilla La Mancha, Fac Med Albacete, Ciudad Real, Spain Show more [ 38 ] Univ Verona, Dept Diagnost & Publ Hlth, Unit Epidemiol & Med Stat, Verona, Italyen
dc.identifier.journalThoraxen
dc.rights.accessOpen Access - Opinn aðganguren
dc.departmentcodePAD12
refterms.dateFOA2018-09-12T16:58:43Z
html.description.abstractBACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy. METHODS: The European Community Respiratory Health Survey collected information on prevalent asthma-like symptoms from representative samples of adults aged 20-44 years (29 centres in 13 European countries and Australia) at baseline and 10 and 20 years later (n=7844). Net changes in symptom prevalence were determined using generalised estimating equations (accounting for non-response through inverse probability weighting), followed by meta-analysis of centre level estimates. FINDINGS: Over 20 years the prevalence of 'wheeze' and 'wheeze in the absence of a cold' decreased (-2.4%, 95% CI -3.5 to -1.3%; -1.5%, 95% CI -2.4 to -0.6%, respectively) but the prevalence of asthma attacks, use of asthma medication and hay fever/nasal allergies increased (0.6%, 95% CI 0.1 to 1.11; 3.6%, 95% CI 3.0 to 4.2; 2.7%, 95% CI 1.7 to 3.7). Changes were similar in the first 10 years compared with the second 10 years, except for hay fever/nasal allergies (increase seen in the first 10 years only). Decreases in these wheeze-related symptoms were largely seen in the group who gave up smoking, and were seen in those who reported hay fever/nasal allergies at baseline. INTERPRETATION: European adults born between 1946 and 1970 have, over the last 20 years, experienced less wheeze, although they were more likely to report asthma attacks, use of asthma medication and hay fever. Decrease in wheeze is largely attributable to smoking cessation, rather than improved treatment of asthma. It may also be influenced by reductions in atopy with ageing.


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