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dc.contributor.authorCaers, J.
dc.contributor.authorPaiva, B.
dc.contributor.authorZamagni, E.
dc.contributor.authorLeleu, X.
dc.contributor.authorBladé, J.
dc.contributor.authorKristinsson, S. Y.
dc.contributor.authorTouzeau, C.
dc.contributor.authorAbildgaard, N.
dc.contributor.authorTerpos, E.
dc.contributor.authorHeusschen, R.
dc.contributor.authorOcio, E.
dc.contributor.authorDelforge, M.
dc.contributor.authorSezer, O.
dc.contributor.authorBeksac, M.
dc.contributor.authorLudwig, H.
dc.contributor.authorMerlini, G.
dc.contributor.authorMoreau, P.
dc.contributor.authorZweegman, S.
dc.contributor.authorEngelhardt, M.
dc.contributor.authorRosiñol, L.
dc.date.accessioned2018-02-09T11:20:04Z
dc.date.available2018-02-09T11:20:04Z
dc.date.issued2018-01-16
dc.date.submitted2018
dc.identifier.citationDiagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel 2018, 11 (1) Journal of Hematology & Oncologyen
dc.identifier.issn1756-8722
dc.identifier.doi10.1186/s13045-017-0549-1
dc.identifier.urihttp://hdl.handle.net/2336/620465
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Filesen
dc.description.abstractSolitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Before treatment initiation, whole body positron emission tomography-computed tomography or magnetic resonance imaging should be performed to exclude the presence of additional malignant lesions. For decades, treatment has been based on high-dose radiation, but studies exploring the potential benefit of systemic therapies for high-risk patients are urgently needed. In this review, a panel of expert European hematologists updates the recommendations on the diagnosis and management of patients with solitary plasmacytoma.
dc.description.sponsorshipBelgian Foundation against Cancer Fonds National de la Recherche Scientifique Deutsche Krebshilfe Asociacion Espanola Contra el Canceren
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttps://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0549-1en
dc.rightsArchived with thanks to Journal of Hematology & Oncologyen
dc.subjectKrabbameinslækningaren
dc.subjectBlóðsjúkdómaren
dc.subjectHEM12en
dc.subject.meshPlasmacytomaen
dc.subject.meshMagnetic Resonance Imagingen
dc.subject.meshTherapeuticsen
dc.titleDiagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panelen
dc.typeArticleen
dc.contributor.departmentShow more [ 1 ] CHU Liege, Dept Hematol, Liege, Belgium Show more [ 2 ] Clin Univ Navarra, CIMA, Pamplona, Spain Show more [ 3 ] Clin Univ Navarra, Inst Invest Sanitaria Navarra IDISNA, CIBERONC, Pamplona, Spain Show more [ 4 ] Bologna Univ, Seragnoli Inst Hematol, Sch Med, Bologna, Italy Show more [ 5 ] Univ Hosp Poitiers, Hop Miletrie, Poitiers, France Show more [ 6 ] Hosp Clin Barcelona, Dept Hematol, IDIBAPS, Barcelona, Spain Show more [ 7 ] Landspitali Natl Univ Hosp, Dept Hematol, Reykjavik, Iceland Show more [ 8 ] Univ Hosp Hotel Dieu, Dept Hematol, Nantes, France Show more [ 9 ] Odense Univ Hosp, Dept Hematol, Odense, Denmark Show more [ 10 ] Univ Athens, Sch Med, Dept Clin Therapeut, Athens, Greece Show more [ 11 ] Hosp Univ Salamanca, Ctr Invest Canc, Inst Invest Biomed Salamanca, Salamanca, Spain Show more [ 12 ] Univ Hosp Leuven, Dept Hematol, Leuven, Belgium [ 13 ] Univ Kilinikum Eppendorf, Dept Haematol Oncol & Bone Marrow Transplantat, Hamburg, Germany Show more [ 14 ] Univ Ankara, Dept Hematol, Ankara, Turkey Show more [ 15 ] Wilhelminen Hosp, Dept Med 1, Vienna, Austria Show more [ 16 ] Univ Pavia, Fdn Ist Ricovero & Cura Carattere Sci IRCCS, Amyloidosis Res & Treatment Ctr, Policlin San Matteo,Dept Mol Med, Pavia, Italy Show more [ 17 ] Vrije Univ Amsterdam, Dept Hematol, Med Ctr, Amsterdam, Netherlands Show more [ 18 ] Univ Freiburg, Dept Hematol & Oncol, Med Ctr, Freiburg, Germanyen
dc.identifier.journalJournal of Hematology & Oncologyen
dc.rights.accessOpen Access - Opinn aðganguren
dc.departmentcodeHEM12
refterms.dateFOA2018-09-12T17:02:57Z
html.description.abstractSolitary plasmacytoma is an infrequent form of plasma cell dyscrasia that presents as a single mass of monoclonal plasma cells, located either extramedullary or intraosseous. In some patients, a bone marrow aspiration can detect a low monoclonal plasma cell infiltration which indicates a high risk of early progression to an overt myeloma disease. Before treatment initiation, whole body positron emission tomography-computed tomography or magnetic resonance imaging should be performed to exclude the presence of additional malignant lesions. For decades, treatment has been based on high-dose radiation, but studies exploring the potential benefit of systemic therapies for high-risk patients are urgently needed. In this review, a panel of expert European hematologists updates the recommendations on the diagnosis and management of patients with solitary plasmacytoma.


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