Indoor bacteria and asthma in adults: a multicentre case-control study within ECRHS II.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Kärkkäinen, Päivi M
MetadataShow full item record
CitationIndoor bacteria and asthma in adults: a multicentre case-control study within ECRHS II. 2018, 51 (2) Eur. Respir. J.
AbstractBoth protective and adverse effects of indoor microbial exposure on asthma have been reported, but mostly in children. To date, no study in adults has used non-targeted methods for detection of indoor bacteria followed by quantitative confirmation.A cross-sectional study of 198 asthmatic and 199 controls was conducted within the European Community Respiratory Health Survey (ECRHS) II. DNA was extracted from mattress dust for bacterial analysis using denaturing gradient gel electrophoresis (DGGE). Selected bands were sequenced and associations with asthma confirmed with four quantitative PCR (qPCR) assays.15 out of 37 bands detected with DGGE, which had at least a suggestive association (p<0.25) with asthma, were sequenced. Of the four targeted qPCRs,Clostridiumcluster XI confirmed the protective association with asthma. The association was dose dependent (aOR 0.43 (95% CI 0.22-0.84) for the fourthversusfirst quartile, p for trend 0.009) and independent of other microbial markers. Few significant associations were observed for the three other qPCRs used.In this large international study, the level ofClostridiumcluster XI was independently associated with a lower risk of prevalent asthma. Results suggest the importance of environmental bacteria also in adult asthma, but need to be confirmed in future studies.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
RightsArchived with thanks to The European respiratory journal
- Bacterial Exposures and Associations with Atopy and Asthma in Children.
- Authors: Valkonen M, Wouters IM, Täubel M, Rintala H, Lenters V, Vasara R, Genuneit J, Braun-Fahrländer C, Piarroux R, von Mutius E, Heederik D, Hyvärinen A
- Issue date: 2015
- Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort.
- Authors: Valkonen M, Täubel M, Pekkanen J, Tischer C, Rintala H, Zock JP, Casas L, Probst-Hensch N, Forsberg B, Holm M, Janson C, Pin I, Gislason T, Jarvis D, Heinrich J, Hyvärinen A
- Issue date: 2018 Jan
- Predicted risk of childhood allergy, asthma, and reported symptoms using measured phthalate exposure in dust and urine.
- Authors: Hsu NY, Lee CC, Wang JY, Li YC, Chang HW, Chen CY, Bornehag CG, Wu PC, Sundell J, Su HJ
- Issue date: 2012 Jun
- Predictors of microbial agents in dust and respiratory health in the Ecrhs.
- Authors: Tischer C, Zock JP, Valkonen M, Doekes G, Guerra S, Heederik D, Jarvis D, Norbäck D, Olivieri M, Sunyer J, Svanes C, Täubel M, Thiering E, Verlato G, Hyvärinen A, Heinrich J
- Issue date: 2015 May 2
- The association between endotoxin and beta-(1 → 3)-D-glucan in house dust with asthma severity among schoolchildren.
- Authors: Oluwole O, Rennie DC, Senthilselvan A, Dyck R, Afanasieva A, Kirychuk S, Katselis G, Lawson JA
- Issue date: 2018 May