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Systems biology as an emerging paradigm in transfusion medicine

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Authors
Yurkovich, James T.
Bordbar, Aarash
Sigurjónsson, Ólafur E.
Yurkovich, James T.
Issue Date
2018-03-07

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Systems biology as an emerging paradigm in transfusion medicine 2018, 12 (1) BMC Systems Biology
Abstract
Blood transfusions are an important part of modern medicine, delivering approximately 85 million blood units to patients annually. Recently, the field of transfusion medicine has started to benefit from the "omic" data revolution and corresponding systems biology analytics. The red blood cell is the simplest human cell, making it an accessible starting point for the application of systems biology approaches.In this review, we discuss how the use of systems biology has led to significant contributions in transfusion medicine, including the identification of three distinct metabolic states that define the baseline decay process of red blood cells during storage. We then describe how a series of perturbations to the standard storage conditions characterized the underlying metabolic phenotypes. Finally, we show how the analysis of high-dimensional data led to the identification of predictive biomarkers.The transfusion medicine community is in the early stages of a paradigm shift, moving away from the measurement of a handful of chosen variables to embracing systems biology and a cell-scale point of view.
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https://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-018-0558-x
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Archived with thanks to BMC Systems Biology
ae974a485f413a2113503eed53cd6c53
10.1186/s12918-018-0558-x
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English Journal Articles (Peer Reviewed)

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