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dc.contributor.authorAnttila, Verneri
dc.contributor.authorBulik-Sullivan, Brendan
dc.contributor.authorFinucane, Hilary K.
dc.contributor.authorWalters, Raymond K.
dc.contributor.authorBras, Jose
dc.contributor.authorDuncan, Laramie
dc.contributor.authorEscott-Price, Valentina
dc.contributor.authorFalcone, Guido J.
dc.contributor.authorGormley, Padhraig
dc.contributor.authorMalik, Rainer
dc.contributor.authorPatsopoulos, Nikolaos A.
dc.contributor.authorRipke, Stephan
dc.contributor.authorWei, Zhi
dc.contributor.authorYu, Dongmei
dc.contributor.authorLee, Phil H.
dc.contributor.authorTurley, Patrick
dc.contributor.authorGrenier-Boley, Benjamin
dc.contributor.authorChouraki, Vincent
dc.contributor.authorKamatani, Yoichiro
dc.contributor.authorBerr, Claudine
dc.contributor.authorLetenneur, Luc
dc.contributor.authorHannequin, Didier
dc.contributor.authorAmouyel, Philippe
dc.contributor.authorBoland, Anne
dc.contributor.authorDeleuze, Jean-François
dc.contributor.authorDuron, Emmanuelle
dc.contributor.authorVardarajan, Badri N.
dc.contributor.authorReitz, Christiane
dc.contributor.authorGoate, Alison M.
dc.contributor.authorHuentelman, Matthew J.
dc.contributor.authorKamboh, M. Ilyas
dc.contributor.authorLarson, Eric B.
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorSt George-Hyslop, Peter
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorKukull, Walter A.
dc.contributor.authorFarrer, Lindsay A.
dc.contributor.authorBarnes, Lisa L.
dc.contributor.authorBeach, Thomas G.
dc.contributor.authorDemirci, F. Yesim
dc.contributor.authorHead, Elizabeth
dc.contributor.authorHulette, Christine M.
dc.contributor.authorJicha, Gregory A.
dc.contributor.authorKauwe, John S.K.
dc.contributor.authorKaye, Jeffrey A.
dc.contributor.authorLeverenz, James B.
dc.contributor.authorLevey, Allan I.
dc.contributor.authorLieberman, Andrew P.
dc.contributor.authorPankratz, Vernon S.
dc.contributor.authorPoon, Wayne W.
dc.contributor.authorQuinn, Joseph F.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorSchneider, Lon S.
dc.contributor.authorSmith, Amanda G.
dc.contributor.authorSonnen, Joshua A.
dc.contributor.authorStern, Robert A.
dc.contributor.authorVan Deerlin, Vivianna M.
dc.contributor.authorVan Eldik, Linda J.
dc.contributor.authorHarold, Denise
dc.contributor.authorRusso, Giancarlo
dc.contributor.authorRubinsztein, David C.
dc.contributor.authorBayer, Anthony
dc.contributor.authorTsolaki, Magda
dc.contributor.authorProitsi, Petra
dc.contributor.authorFox, Nick C.
dc.contributor.authorHampel, Harald
dc.contributor.authorOwen, Michael J.
dc.contributor.authorMead, Simon
dc.contributor.authorPassmore, Peter
dc.contributor.authorMorgan, Kevin
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorSchott, Jonathan M.
dc.contributor.authorRossor, Martin
dc.contributor.authorLupton, Michelle K.
dc.contributor.authorHoffmann, Per
dc.contributor.authorKornhuber, Johannes
dc.contributor.authorLawlor, Brian
dc.contributor.authorMcQuillin, Andrew
dc.contributor.authorAl-Chalabi, Ammar
dc.contributor.authorBis, Joshua C
dc.contributor.authorRuiz, Agustin
dc.contributor.authorBoada, Mercè
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorBeiser, Alexa
dc.contributor.authorRice, Kenneth
dc.contributor.authorvan der Lee, Sven J.
dc.contributor.authorDe Jager, Philip L.
dc.contributor.authorGeschwind, Daniel H.
dc.contributor.authorRiemenschneider, Matthias
dc.contributor.authorRiedel-Heller, Steffi
dc.contributor.authorRotter, Jerome I
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorHyman, Bradley T.
dc.contributor.authorCruchaga, Carlos
dc.contributor.authorAlegret, Montserrat
dc.contributor.authorWinsvold, Bendik
dc.contributor.authorPalta, Priit
dc.contributor.authorFarh, Kai-How
dc.contributor.authorCuenca-Leon, Ester
dc.contributor.authorFurlotte, Nicholas
dc.contributor.authorKurth, Tobias
dc.contributor.authorLigthart, Lannie
dc.contributor.authorTerwindt, Gisela M.
dc.contributor.authorFreilinger, Tobias
dc.contributor.authorRan, Caroline
dc.contributor.authorGordon, Scott D.
dc.contributor.authorBorck, Guntram
dc.contributor.authorAdams, Hieab H.H.
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorWedenoja, Juho
dc.contributor.authorBuring, Julie E.
dc.contributor.authorSchürks, Markus
dc.contributor.authorHrafnsdottir, Maria
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorPenninx, Brenda
dc.contributor.authorArtto, Ville
dc.contributor.authorKaunisto, Mari
dc.contributor.authorVepsäläinen, Salli
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorKurki, Mitja I.
dc.contributor.authorHämäläinen, Eija
dc.contributor.authorHuang, Hailiang
dc.contributor.authorHuang, Jie
dc.contributor.authorSandor, Cynthia
dc.contributor.authorWebber, Caleb
dc.contributor.authorMuller-Myhsok, Bertram
dc.contributor.authorSchreiber, Stefan
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorLoehrer, Elizabeth
dc.contributor.authorGöbel, Hartmut
dc.contributor.authorMacaya, Alfons
dc.contributor.authorPozo-Rosich, Patricia
dc.contributor.authorHansen, Thomas
dc.contributor.authorWerge, Thomas
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorMetspalu, Andres
dc.contributor.authorKubisch, Christian
dc.contributor.authorFerrari, Michel D.
dc.contributor.authorBelin, Andrea C.
dc.contributor.authorvan den Maagdenberg, Arn M.J.M.
dc.contributor.authorZwart, John-Anker
dc.contributor.authorBoomsma, Dorret
dc.contributor.authorEriksson, Nicholas
dc.contributor.authorOlesen, Jes
dc.contributor.authorChasman, Daniel I.
dc.contributor.authorNyholt, Dale R.
dc.contributor.authorAnney, Richard
dc.contributor.authorAvbersek, Andreja
dc.contributor.authorBaum, Larry
dc.contributor.authorBerkovic, Samuel
dc.contributor.authorBradfield, Jonathan
dc.contributor.authorBuono, Russell
dc.contributor.authorCatarino, Claudia B.
dc.contributor.authorCossette, Patrick
dc.contributor.authorDe Jonghe, Peter
dc.contributor.authorDepondt, Chantal
dc.contributor.authorDlugos, Dennis
dc.contributor.authorFerraro, Thomas N.
dc.contributor.authorFrench, Jacqueline
dc.contributor.authorHjalgrim, Helle
dc.contributor.authorJamnadas-Khoda, Jennifer
dc.contributor.authorKälviäinen, Reetta
dc.contributor.authorKunz, Wolfram S.
dc.contributor.authorLerche, Holger
dc.contributor.authorLeu, Costin
dc.contributor.authorLindhout, Dick
dc.contributor.authorLo, Warren
dc.contributor.authorLowenstein, Daniel
dc.contributor.authorMcCormack, Mark
dc.contributor.authorMøller, Rikke S.
dc.contributor.authorMolloy, Anne
dc.contributor.authorNg, Ping-Wing
dc.contributor.authorOliver, Karen
dc.contributor.authorPrivitera, Michael
dc.contributor.authorRadtke, Rodney
dc.contributor.authorRuppert, Ann-Kathrin
dc.contributor.authorSander, Thomas
dc.contributor.authorSchachter, Steven
dc.contributor.authorSchankin, Christoph
dc.contributor.authorScheffer, Ingrid
dc.contributor.authorSchoch, Susanne
dc.contributor.authorSisodiya, Sanjay M.
dc.contributor.authorSmith, Philip
dc.contributor.authorSperling, Michael
dc.contributor.authorStriano, Pasquale
dc.contributor.authorSurges, Rainer
dc.contributor.authorThomas, G. Neil
dc.contributor.authorVisscher, Frank
dc.contributor.authorWhelan, Christopher D.
dc.contributor.authorZara, Federico
dc.contributor.authorHeinzen, Erin L.
dc.contributor.authorMarson, Anthony
dc.contributor.authorBecker, Felicitas
dc.contributor.authorStroink, Hans
dc.contributor.authorZimprich, Fritz
dc.contributor.authorGasser, Thomas
dc.contributor.authorGibbs, Raphael
dc.contributor.authorHeutink, Peter
dc.contributor.authorMartinez, Maria
dc.contributor.authorMorris, Huw R.
dc.contributor.authorSharma, Manu
dc.contributor.authorRyten, Mina
dc.contributor.authorMok, Kin Y.
dc.contributor.authorPulit, Sara
dc.contributor.authorBevan, Steve
dc.contributor.authorHolliday, Elizabeth
dc.contributor.authorAttia, John
dc.contributor.authorBattey, Thomas
dc.contributor.authorBoncoraglio, Giorgio
dc.contributor.authorThijs, Vincent
dc.contributor.authorChen, Wei-Min
dc.contributor.authorMitchell, Braxton
dc.contributor.authorRothwell, Peter
dc.contributor.authorSharma, Pankaj
dc.contributor.authorSudlow, Cathie
dc.contributor.authorVicente, Astrid
dc.contributor.authorMarkus, Hugh
dc.contributor.authorKourkoulis, Christina
dc.contributor.authorPera, Joana
dc.contributor.authorRaffeld, Miriam
dc.contributor.authorSilliman, Scott
dc.contributor.authorBoraska Perica, Vesna
dc.contributor.authorThornton, Laura M.
dc.contributor.authorHuckins, Laura M.
dc.contributor.authorWilliam Rayner, N.
dc.contributor.authorLewis, Cathryn M.
dc.contributor.authorGratacos, Monica
dc.contributor.authorRybakowski, Filip
dc.contributor.authorKeski-Rahkonen, Anna
dc.contributor.authorRaevuori, Anu
dc.contributor.authorHudson, James I.
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorMonteleone, Palmiero
dc.contributor.authorKarwautz, Andreas
dc.contributor.authorMannik, Katrin
dc.contributor.authorBaker, Jessica H.
dc.contributor.authorO’Toole, Julie K.
dc.contributor.authorTrace, Sara E.
dc.contributor.authorDavis, Oliver S. P.
dc.contributor.authorHelder, Sietske G.
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorHerpertz-Dahlmann, Beate
dc.contributor.authorDanner, Unna N.
dc.contributor.authorvan Elburg, Annemarie A.
dc.contributor.authorClementi, Maurizio
dc.contributor.authorForzan, Monica
dc.contributor.authorDocampo, Elisa
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorHauser, Joanna
dc.contributor.authorTortorella, Alfonso
dc.contributor.authorMaj, Mario
dc.contributor.authorGonidakis, Fragiskos
dc.contributor.authorTziouvas, Konstantinos
dc.contributor.authorPapezova, Hana
dc.contributor.authorYilmaz, Zeynep
dc.contributor.authorWagner, Gudrun
dc.contributor.authorCohen-Woods, Sarah
dc.contributor.authorHerms, Stefan
dc.contributor.authorJulià, Antonio
dc.contributor.authorRabionet, Raquel
dc.contributor.authorDick, Danielle M.
dc.contributor.authorRipatti, Samuli
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorLundervold, Astri J.
dc.contributor.authorSteen, Vidar M.
dc.contributor.authorPinto, Dalila
dc.contributor.authorScherer, Stephen W.
dc.contributor.authorAschauer, Harald
dc.contributor.authorSchosser, Alexandra
dc.contributor.authorAlfredsson, Lars
dc.contributor.authorPadyukov, Leonid
dc.contributor.authorHalmi, Katherine A.
dc.contributor.authorMitchell, James
dc.contributor.authorStrober, Michael
dc.contributor.authorBergen, Andrew W.
dc.contributor.authorKaye, Walter
dc.contributor.authorSzatkiewicz, Jin Peng
dc.contributor.authorCormand, Bru
dc.contributor.authorRamos-Quiroga, Josep Antoni
dc.contributor.authorSánchez-Mora, Cristina
dc.contributor.authorRibasés, Marta
dc.contributor.authorCasas, Miguel
dc.contributor.authorHervas, Amaia
dc.contributor.authorArranz, Maria Jesús
dc.contributor.authorHaavik, Jan
dc.contributor.authorZayats, Tetyana
dc.contributor.authorJohansson, Stefan
dc.contributor.authorWilliams, Nigel
dc.contributor.authorElia, Josephine
dc.contributor.authorDempfle, Astrid
dc.contributor.authorRothenberger, Aribert
dc.contributor.authorKuntsi, Jonna
dc.contributor.authorOades, Robert D.
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorFranke, Barbara
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorArias Vasquez, Alejandro
dc.contributor.authorDoyle, Alysa E.
dc.contributor.authorReif, Andreas
dc.contributor.authorLesch, Klaus-Peter
dc.contributor.authorFreitag, Christine
dc.contributor.authorRivero, Olga
dc.contributor.authorPalmason, Haukur
dc.contributor.authorRomanos, Marcel
dc.contributor.authorLangley, Kate
dc.contributor.authorRietschel, Marcella
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorDalsgaard, Soeren
dc.contributor.authorBørglum, Anders D.
dc.contributor.authorWaldman, Irwin
dc.contributor.authorWilmot, Beth
dc.contributor.authorMolly, Nikolas
dc.contributor.authorBau, Claiton H.D.
dc.contributor.authorCrosbie, Jennifer
dc.contributor.authorSchachar, Russell
dc.contributor.authorLoo, Sandra K.
dc.contributor.authorMcGough, James J.
dc.contributor.authorGrevet, Eugenio H.
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorRobinson, Elise
dc.contributor.authorWeiss, Lauren A.
dc.contributor.authorBacchelli, Elena
dc.contributor.authorBailey, Anthony
dc.contributor.authorBal, Vanessa
dc.contributor.authorBattaglia, Agatino
dc.contributor.authorBetancur, Catalina
dc.contributor.authorBolton, Patrick
dc.contributor.authorCantor, Rita
dc.contributor.authorCelestino-Soper, Patrícia
dc.contributor.authorDawson, Geraldine
dc.contributor.authorDe Rubeis, Silvia
dc.contributor.authorDuque, Frederico
dc.contributor.authorGreen, Andrew
dc.contributor.authorKlauck, Sabine M.
dc.contributor.authorLeboyer, Marion
dc.contributor.authorLevitt, Pat
dc.contributor.authorMaestrini, Elena
dc.contributor.authorMane, Shrikant
dc.contributor.authorDe-Luca, Daniel Moreno-
dc.contributor.authorParr, Jeremy
dc.contributor.authorRegan, Regina
dc.contributor.authorReichenberg, Abraham
dc.contributor.authorSandin, Sven
dc.contributor.authorVorstman, Jacob
dc.contributor.authorWassink, Thomas
dc.contributor.authorWijsman, Ellen
dc.contributor.authorCook, Edwin
dc.contributor.authorSantangelo, Susan
dc.contributor.authorDelorme, Richard
dc.contributor.authorRogé, Bernadette
dc.contributor.authorMagalhaes, Tiago
dc.contributor.authorArking, Dan
dc.contributor.authorSchulze, Thomas G.
dc.contributor.authorThompson, Robert C.
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorMatthews, Keith
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMorris, Derek
dc.contributor.authorBlackwood, Douglas
dc.contributor.authorMcIntosh, Andrew
dc.contributor.authorBergen, Sarah E
dc.contributor.authorSchalling, Martin
dc.contributor.authorJamain, Stéphane
dc.contributor.authorMaaser, Anna
dc.contributor.authorFischer, Sascha B.
dc.contributor.authorReinbold, Céline S.
dc.contributor.authorFullerton, Janice M.
dc.contributor.authorGrigoroiu-Serbanescu, Maria
dc.contributor.authorGuzman-Parra, José
dc.contributor.authorMayoral, Fermin
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorCichon, Sven
dc.contributor.authorMühleisen, Thomas W.
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorSchumacher, Johannes
dc.contributor.authorBauer, Michael
dc.contributor.authorMitchell, Philip B.
dc.contributor.authorGershon, Elliot S.
dc.contributor.authorRice, John
dc.contributor.authorPotash, James B.
dc.contributor.authorZandi, Peter P.
dc.contributor.authorCraddock, Nick
dc.contributor.authorFerrier, I. Nicol
dc.contributor.authorAlda, Martin
dc.contributor.authorRouleau, Guy A.
dc.contributor.authorTurecki, Gustavo
dc.contributor.authorOphoff, Roel
dc.contributor.authorPato, Carlos
dc.contributor.authorAnjorin, Adebayo
dc.contributor.authorStahl, Eli
dc.contributor.authorLeber, Markus
dc.contributor.authorCzerski, Piotr M.
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorCruceanu, Cristiana
dc.contributor.authorJones, Ian R.
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorAndlauer, Till F.M.
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorStreit, Fabian
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorAir, Tracy
dc.contributor.authorSinnamon, Grant
dc.contributor.authorWray, Naomi R.
dc.contributor.authorMacIntyre, Donald J.
dc.contributor.authorPorteous, David
dc.contributor.authorHomuth, Georg
dc.contributor.authorRivera, Margarita
dc.contributor.authorGrove, Jakob
dc.contributor.authorMiddeldorp, Christel M.
dc.contributor.authorHickie, Ian
dc.contributor.authorPergadia, Michele
dc.contributor.authorMehta, Divya
dc.contributor.authorSmit, Johannes H.
dc.contributor.authorJansen, Rick
dc.contributor.authorde Geus, Eco
dc.contributor.authorDunn, Erin
dc.contributor.authorLi, Qingqin S.
dc.contributor.authorNauck, Matthias
dc.contributor.authorSchoevers, Robert A.
dc.contributor.authorBeekman, Aartjan TF
dc.contributor.authorKnowles, James A.
dc.contributor.authorViktorin, Alexander
dc.contributor.authorArnold, Paul
dc.contributor.authorBarr, Cathy L.
dc.contributor.authorBedoya-Berrio, Gabriel
dc.contributor.authorBienvenu, O. Joseph
dc.contributor.authorBrentani, Helena
dc.contributor.authorBurton, Christie
dc.contributor.authorCamarena, Beatriz
dc.contributor.authorCappi, Carolina
dc.contributor.authorCath, Danielle
dc.contributor.authorCavallini, Maria
dc.contributor.authorCusi, Daniele
dc.contributor.authorDarrow, Sabrina
dc.contributor.authorDenys, Damiaan
dc.contributor.authorDerks, Eske M.
dc.contributor.authorDietrich, Andrea
dc.contributor.authorFernandez, Thomas
dc.contributor.authorFigee, Martijn
dc.contributor.authorFreimer, Nelson
dc.contributor.authorGerber, Gloria
dc.contributor.authorGrados, Marco
dc.contributor.authorGreenberg, Erica
dc.contributor.authorHanna, Gregory L.
dc.contributor.authorHartmann, Andreas
dc.contributor.authorHirschtritt, Matthew E.
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHuang, Alden
dc.contributor.authorHuyser, Chaim
dc.contributor.authorIllmann, Cornelia
dc.contributor.authorJenike, Michael
dc.contributor.authorKuperman, Samuel
dc.contributor.authorLeventhal, Bennett
dc.contributor.authorLochner, Christine
dc.contributor.authorLyon, Gholson J.
dc.contributor.authorMacciardi, Fabio
dc.contributor.authorMadruga-Garrido, Marcos
dc.contributor.authorMalaty, Irene A.
dc.contributor.authorMaras, Athanasios
dc.contributor.authorMcGrath, Lauren
dc.contributor.authorMiguel, Eurípedes C.
dc.contributor.authorMir, Pablo
dc.contributor.authorNestadt, Gerald
dc.contributor.authorNicolini, Humberto
dc.contributor.authorOkun, Michael S.
dc.contributor.authorPakstis, Andrew
dc.contributor.authorPaschou, Peristera
dc.contributor.authorPiacentini, John
dc.contributor.authorPittenger, Christopher
dc.contributor.authorPlessen, Kerstin
dc.contributor.authorRamensky, Vasily
dc.contributor.authorRamos, Eliana M.
dc.contributor.authorReus, Victor
dc.contributor.authorRichter, Margaret A.
dc.contributor.authorRiddle, Mark A.
dc.contributor.authorRobertson, Mary M.
dc.contributor.authorRoessner, Veit
dc.contributor.authorRosário, Maria
dc.contributor.authorSamuels, Jack F.
dc.contributor.authorSandor, Paul
dc.contributor.authorStein, Dan J.
dc.contributor.authorTsetsos, Fotis
dc.contributor.authorVan Nieuwerburgh, Filip
dc.contributor.authorWeatherall, Sarah
dc.contributor.authorWendland, Jens R.
dc.contributor.authorWolanczyk, Tomasz
dc.contributor.authorWorbe, Yulia
dc.contributor.authorZai, Gwyneth
dc.contributor.authorGoes, Fernando S.
dc.contributor.authorMcLaughlin, Nicole
dc.contributor.authorNestadt, Paul S.
dc.contributor.authorGrabe, Hans-Jorgen
dc.contributor.authorDepienne, Christel
dc.contributor.authorKonkashbaev, Anuar
dc.contributor.authorLanzagorta, Nuria
dc.contributor.authorValencia-Duarte, Ana
dc.contributor.authorBramon, Elvira
dc.contributor.authorBuccola, Nancy
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCairns, Murray
dc.contributor.authorChong, Siow A.
dc.contributor.authorCohen, David
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorCrowley, James
dc.contributor.authorDavidson, Michael
dc.contributor.authorDeLisi, Lynn
dc.contributor.authorDinan, Timothy
dc.contributor.authorDonohoe, Gary
dc.contributor.authorDrapeau, Elodie
dc.contributor.authorDuan, Jubao
dc.contributor.authorHaan, Lieuwe
dc.contributor.authorHougaard, David
dc.contributor.authorKarachanak-Yankova, Sena
dc.contributor.authorKhrunin, Andrey
dc.contributor.authorKlovins, Janis
dc.contributor.authorKučinskas, Vaidutis
dc.contributor.authorLee Chee Keong, Jimmy
dc.contributor.authorLimborska, Svetlana
dc.contributor.authorLoughland, Carmel
dc.contributor.authorLönnqvist, Jouko
dc.contributor.authorMaher, Brion
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMurphy, Kieran C.
dc.contributor.authorMurray, Robin
dc.contributor.authorNenadic, Igor
dc.contributor.authorvan Os, Jim
dc.contributor.authorPantelis, Christos
dc.contributor.authorPato, Michele
dc.contributor.authorPetryshen, Tracey
dc.contributor.authorQuested, Digby
dc.contributor.authorRoussos, Panos
dc.contributor.authorSanders, Alan R.
dc.contributor.authorSchall, Ulrich
dc.contributor.authorSchwab, Sibylle G.
dc.contributor.authorSim, Kang
dc.contributor.authorSo, Hon-Cheong
dc.contributor.authorStögmann, Elisabeth
dc.contributor.authorSubramaniam, Mythily
dc.contributor.authorToncheva, Draga
dc.contributor.authorWaddington, John
dc.contributor.authorWalters, James
dc.contributor.authorWeiser, Mark
dc.contributor.authorCheng, Wei
dc.contributor.authorCloninger, Robert
dc.contributor.authorCurtis, David
dc.contributor.authorGejman, Pablo V.
dc.contributor.authorHenskens, Frans
dc.contributor.authorMattingsdal, Morten
dc.contributor.authorOh, Sang-Yun
dc.contributor.authorScott, Rodney
dc.contributor.authorWebb, Bradley
dc.contributor.authorBreen, Gerome
dc.contributor.authorChurchhouse, Claire
dc.contributor.authorBulik, Cynthia M.
dc.contributor.authorDaly, Mark
dc.contributor.authorDichgans, Martin
dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorHolmans, Peter
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorKoeleman, Bobby
dc.contributor.authorMathews, Carol A.
dc.contributor.authorPrice, Alkes
dc.contributor.authorScharf, Jeremiah
dc.contributor.authorSklar, Pamela
dc.contributor.authorWilliams, Julie
dc.contributor.authorWood, Nicholas W.
dc.contributor.authorCotsapas, Chris
dc.contributor.authorPalotie, Aarno
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorSullivan, Patrick
dc.contributor.authorRosand, Jonathan
dc.contributor.authorCorvin, Aiden
dc.contributor.authorNeale, Benjamin M.
dc.date.accessioned2018-08-13T10:54:29Z
dc.date.available2018-08-13T10:54:29Z
dc.date.issued2018-06-22
dc.date.submitted2018
dc.identifier.citationAnalysis of shared heritability in common disorders of the brain 2018, 360 (6395):eaap8757 Scienceen
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.doi10.1126/science.aap8757
dc.identifier.urihttp://hdl.handle.net/2336/620652
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Filesen
dc.description.abstractDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
dc.description.sponsorshipNIMH NIH HHS NIAen
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Scienceen
dc.relation.urlhttp://www.sciencemag.org/lookup/doi/10.1126/science.aap8757en
dc.rightsArchived with thanks to Scienceen
dc.subjectHeilabilunen
dc.subjectArfgengien
dc.subjectGenarannsókniren
dc.subject.meshBrain Diseasesen
dc.subject.meshGenome-Wide Association Studyen
dc.subject.otheren
dc.titleAnalysis of shared heritability in common disorders of the brainen
dc.typeArticleen
dc.contributor.department[152 ] Landspitali Natl Univ Hosp, Reykjavik, Icelanden
dc.identifier.journalScienceen
dc.rights.accessOpen Access - Opinn aðganguren
dc.departmentcodeMAO12
refterms.dateFOA2018-09-12T17:25:07Z
html.description.abstractDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.


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