Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Indridason, Olafur S
Levey, Andrew S
MetadataShow full item record
CitationNephrology Dialysis Transplantation 2018;33(8):1380-1388
AbstractValidation studies comparing glomerular filtration rate (GFR) equations based on standardized creatinine and cystatin C assays in the elderly are needed. The Icelandic Age, Gene/Environment Susceptibility-Kidney cohort was used to compare two pairs of recently developed GFR equations, the revised Lund-Malmö creatinine equation (LMRCr) and the arithmetic mean of the LMRCr and Caucasian, Asian, Paediatric and Adult cystatin C equations (MEANLMR+CAPA), as well as the Full Age Spectrum creatinine equation (FASCr) and its combination with cystatin C (FASCr+Cys), with the corresponding pair of Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPICr and CKD-EPICr+Cys). A total of 805 individuals, 74-93 years of age, underwent measurement of GFR (mGFR) using plasma clearance of iohexol. Four metrics were used to compare the performance of the GFR equations: bias, precision, accuracy [including the percentage of participants with estimated GFR (eGFR) within 30% of mGFR (P30)] and the ability to detect mGFR <60 mL/min/1.73 m2. All equations had a P30 >90%. LMRCr and FASCr yielded significantly higher precision and P30 than CKD-EPICr, while bias was significantly worse. LMRCr, FASCr and CKD-EPICr showed similar ability to detect mGFR <60 mL/min/1.73 m2 based on the area under the receiver operating characteristic curves. MEANLMR+CAPA, FASCr+Cys and CKD-EPICr+Cys all exhibited consistent improvements compared with the corresponding creatinine-based equations. None of the creatinine-based equations was clearly superior overall in this community-dwelling elderly cohort. The addition of cystatin C improved all of the creatinine-based equations.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
- GFR estimation based on standardized creatinine and cystatin C: a European multicenter analysis in older adults.
- Authors: Björk J, Bäck SE, Ebert N, Evans M, Grubb A, Hansson M, Jones I, Lamb EJ, Martus P, Schaeffner E, Sjöström P, Nyman U
- Issue date: 2018 Feb 23
- Combining Cystatin C and Creatinine Yields a Reliable Glomerular Filtration Rate Estimation in Older Adults in Contrast to β-Trace Protein and β2-Microglobulin.
- Authors: Werner K, Pihlsgård M, Elmståhl S, Legrand H, Nyman U, Christensson A
- Issue date: 2017
- A comparison between 2017 FAS and 2012 CKD-EPI equations: a multi-center validation study in Chinese adult population.
- Authors: Yong Z, Li F, Pei X, Liu X, Song D, Zhang X, Zhao W
- Issue date: 2019 Jan
- Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children.
- Authors: Björk J, Nyman U, Berg U, Delanaye P, Dubourg L, Goffin K, Grubb A, Hansson M, Littmann K, Åsling-Monemi K, Bökenkamp A, Pottel H
- Issue date: 2019 Jun
- Improved glomerular filtration rate estimation using new equations combined with standardized cystatin C and creatinine in Chinese adult chronic kidney disease patients.
- Authors: Guo X, Qin Y, Zheng K, Gong M, Wu J, Shou W, Cheng X, Xia L, Xu E, Li X, Qiu L
- Issue date: 2014 Sep