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dc.contributor.authorBjörk, Jonas
dc.contributor.authorGrubb, Anders
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorIndridason, Olafur S
dc.contributor.authorLevey, Andrew S
dc.contributor.authorPalsson, Runolfur
dc.contributor.authorNyman, Ulf
dc.date.accessioned2018-08-30T14:48:35Z
dc.date.available2018-08-30T14:48:35Z
dc.date.issued2017-10-05
dc.date.submitted2018-08
dc.identifier.citationNephrology Dialysis Transplantation 2018;33(8):1380-1388en_US
dc.identifier.issn1460-2385
dc.identifier.pmid29040701
dc.identifier.doi10.1093/ndt/gfx272
dc.identifier.urihttp://hdl.handle.net/2336/620676
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractValidation studies comparing glomerular filtration rate (GFR) equations based on standardized creatinine and cystatin C assays in the elderly are needed. The Icelandic Age, Gene/Environment Susceptibility-Kidney cohort was used to compare two pairs of recently developed GFR equations, the revised Lund-Malmö creatinine equation (LMRCr) and the arithmetic mean of the LMRCr and Caucasian, Asian, Paediatric and Adult cystatin C equations (MEANLMR+CAPA), as well as the Full Age Spectrum creatinine equation (FASCr) and its combination with cystatin C (FASCr+Cys), with the corresponding pair of Chronic Kidney Disease Epidemiology Collaboration equations (CKD-EPICr and CKD-EPICr+Cys). A total of 805 individuals, 74-93 years of age, underwent measurement of GFR (mGFR) using plasma clearance of iohexol. Four metrics were used to compare the performance of the GFR equations: bias, precision, accuracy [including the percentage of participants with estimated GFR (eGFR) within 30% of mGFR (P30)] and the ability to detect mGFR <60 mL/min/1.73 m2. All equations had a P30 >90%. LMRCr and FASCr yielded significantly higher precision and P30 than CKD-EPICr, while bias was significantly worse. LMRCr, FASCr and CKD-EPICr showed similar ability to detect mGFR <60 mL/min/1.73 m2 based on the area under the receiver operating characteristic curves. MEANLMR+CAPA, FASCr+Cys and CKD-EPICr+Cys all exhibited consistent improvements compared with the corresponding creatinine-based equations. None of the creatinine-based equations was clearly superior overall in this community-dwelling elderly cohort. The addition of cystatin C improved all of the creatinine-based equations.en_US
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseasesen_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.urlhttps://academic.oup.com/ndt/article-abstract/33/8/1380/4347231?redirectedFrom=fulltexten_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070032/en_US
dc.subjectchronic kidney diseaseen_US
dc.subjectelderlyen_US
dc.subjectglomerular filtration rateen_US
dc.subjectkidney function testsen_US
dc.subjectrenal failureen_US
dc.subject.meshGlomerular Filtration Rateen_US
dc.subject.meshRenal Insufficiency, Chronicen_US
dc.subject.meshRenal Insufficiencyen_US
dc.subject.meshAgeden_US
dc.subject.otheren_US
dc.titleComparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort.en_US
dc.typeArticleen_US
dc.contributor.department1 Clinical Studies Sweden, Forum South, Skåne University Hospital, Lund, Sweden. 2 Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden. 3 Department of Clinical Chemistry, Skåne University Hospital, Lund University, Lund, Sweden. 4 Icelandic Heart Association, Kopavogur, Iceland. 5 University of Iceland, Reykjavik, Iceland. 6 Division of Nephrology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 7 Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA. 8 Department of Translational Medicine, Division of Medical Radiology, Lund University, Malmö, Sweden.en_US
dc.identifier.journalNephrology, dialysis, transplantationen_US
dc.rights.accessClosed - Lokaðen_US
dc.departmentcodeNEP12
dc.source.journaltitleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association


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