Serum ferritin and obstructive sleep apnea-epidemiological study.
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Authors
Thorarinsdottir, Elin HArnardottir, Erna S
Benediktsdottir, Bryndis
Janson, Christer
Olafsson, Isleifur
Pack, Allan I
Gislason, Thorarinn
Keenan, Brendan T
Issue Date
2018-01-01
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Serum ferritin and obstructive sleep apnea-epidemiological study. 2018, 22(3):663-672 Sleep and breathingAbstract
Ferritin is an intracellular iron storage protein and a marker of inflammation. Studies have shown that subjects with obstructive sleep apnea (OSA) have higher levels of circulating pro-inflammatory cytokines, but little is known about the association between ferritin and OSA. The aims of the study were to evaluate serum ferritin (S-Ferritin) levels in OSA patients compared to levels in the general population and also examine the effect of obesity level and treatment with positive airway pressure (PAP) on S-Ferritin levels. The OSA subjects (n = 796) were part of the Icelandic Sleep Apnea Cohort. The control subjects (n = 637) were randomly chosen Icelanders who participated in an epidemiological study. Propensity score (PS) methodologies were employed to minimize selection bias and strengthen causal inferences when comparing non-randomized groups. S-Ferritin levels were measured and all participants answered the same detailed questionnaire about sleep and health. Only OSA patients underwent a sleep study and were re-invited for a 2-year follow-up. S-Ferritin levels were significantly higher in OSA males than controls (213.3 vs. 197.3 μg/L, p = 0.007). However, after adjusting for confounders and using our PS methodology, no significant difference was found. S-Ferritin levels were not correlated with severity of OSA, obesity level, or clinical symptoms. Also, no significant change in S-Ferritin levels was found with 2 years of PAP treatment. S-Ferritin levels are comparable in OSA patients and controls and do not change consistently with obesity level or PAP treatment in our sample.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://link.springer.com/article/10.1007/s11325-017-1598-yae974a485f413a2113503eed53cd6c53
10.1007/s11325-017-1598-y
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