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dc.contributor.authorEinarsdottir, Anna Bryndis
dc.contributor.authorOlafsdottir, Olof Birna
dc.contributor.authorHjaltason, Haukur
dc.contributor.authorHardarson, Sveinn Hakon
dc.date.accessioned2018-10-30T11:29:12Z
dc.date.available2018-10-30T11:29:12Z
dc.date.issued2018-08-01
dc.date.submitted2018-10
dc.identifier.citationRetinal oximetry is affected in multiple sclerosis. 2018, 96(5): 528-530 Acta ophthalmologicaen_US
dc.identifier.issn1755-3768
dc.identifier.pmid29338134
dc.identifier.doi10.1111/aos.13682
dc.identifier.urihttp://hdl.handle.net/2336/620714
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractStructural and physiological abnormalities have been reported in the retina in patients with multiple sclerosis (MS). Retinal oximetry has recently detected changes in retinal oxygen metabolism in Alzheimer's disease and mild cognitive impairment. Our goal was to determine whether oxygen saturation in retinal blood vessels of patients with patients is different from that of a healthy population. Oxygen saturation of haemoglobin was measured in retinal blood vessels, using imaging with spectrophotometric noninvasive retinal oximeter. Eight MS patients with history of optic neuritis were measured and compared to 22 healthy individuals matched in age and gender. Venular oxygen saturation was increased in patients with MS compared to healthy individuals (70.7 ± 3.4% versus 66.2 ± 4.7; p = 0.021, mean ± SD). The arteriovenous (AV) difference was lower in patients with MS compared to healthy (26.6 ± 3.6% versus 30.5 ± 4.8%; p = 0.049). There was no difference measured in arterioles when patients with MS (97.3 ± 1.7%) and healthy individuals (96.7 ± 2.8%) were compared. Increased venular oxygen saturation and lower AV difference in patients with MS may indicate reduced oxygen uptake. This may be due to less oxygen demand following atrophy and may be a useful objective biomarker for MS. Further studies are needed to confirm and expand these findings.en_US
dc.description.sponsorshipAssociation for Research in Vision and Ophthalmologyen_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/aos.13682en_US
dc.subjectbiomarkeren_US
dc.subjectblood vesselsen_US
dc.subjectmultiple sclerosisen_US
dc.subjectoxygenen_US
dc.subjectretinaen_US
dc.subjectretinal oximetryen_US
dc.subjectMS sjúkdómuren_US
dc.subjectSjónhimnaen_US
dc.subjectSúrefnien_US
dc.subject.meshOxygenen_US
dc.subject.meshOximetryen_US
dc.subject.meshRetinaen_US
dc.subject.meshMultiple Sclerosisen_US
dc.titleRetinal oximetry is affected in multiple sclerosis.en_US
dc.typeArticleen_US
dc.contributor.department1 Department of Neurology, Landspitali - National University Hospital, Reykjavik, Iceland. 2 Department of Neurology, Odense University Hospital, Odense, Denmark. 3 Department of Ophthalmology, Landspitali - National University Hospital, Reykjavik, Iceland. 4 University of Iceland, Reykjavik, Iceland.en_US
dc.identifier.journalActa ophthalmologicaen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeNAF12
dc.departmentcodeNEU12
dc.source.journaltitleActa ophthalmologica


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