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dc.contributor.authorSigurdsson, Samuel
dc.contributor.authorEythorsson, Elias
dc.contributor.authorHrafnkelsson, Birgir
dc.contributor.authorErlendsdóttir, Helga
dc.contributor.authorKristinsson, Karl G
dc.contributor.authorHaraldsson, Ásgeir
dc.date.accessioned2018-11-13T11:17:23Z
dc.date.available2018-11-13T11:17:23Z
dc.date.issued2018-09-28
dc.date.submitted2018-11
dc.identifier.citationReduction in All-Cause Acute Otitis Media in Children <3 Years of Age in Primary Care Following Vaccination With 10-Valent Pneumococcal Haemophilus influenzae Protein-D Conjugate Vaccine: A Whole-Population Study. 2018, 67(8):1213-1219 Clinical infectious diseasesen_US
dc.identifier.issn1537-6591
dc.identifier.pmid29617959
dc.identifier.doi10.1093/cid/ciy233
dc.identifier.urihttp://hdl.handle.net/2336/620735
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractThe 10-valent pneumococcal conjugate vaccine (PHiD-CV10) was introduced in Iceland in 2011, without catch-up. The aim of this study was to estimate vaccine impact (VI) on acute otitis media (AOM). In this whole-population study, all primary care visits due to AOM from 2005 to 2015 in children <3 years of age were included. Birth cohorts were grouped as vaccine noneligible (VNEC) or vaccine eligible (VEC). Crude incidence rates (IRs) were compared between the VNEC and VEC. A Cox regression model for repeated events was used to model the individual-level data. VI was calculated as (hazard ratio [HR] - 1) × 100%. Included were 53150 children, with 140912 person-years of follow-up and 58794 AOM episodes. Both IR and the mean number of episodes differed significantly between VNEC and VEC; 43 compared to 38 episodes per 100 person-years and 1.61 episodes per child compared to 1.37. IR was significantly reduced in all age brackets, with the largest reduction in children <4 months of age (40% [95% confidence interval {CI}, 31%-49%). The VI on all-cause AOM was 22% (95% CI, 12%-31%). The impact was mediated through its effect on the first (HR, 0.84 [95% CI, .82-.86]) and second (HR, 0.95 [95% CI, .93-.98]) episodes. The impact of PHiD-CV10 on all-cause AOM was considerable, mediated mainly by preventing the first two episodes of AOM. A decrease in the IR of AOM in children too young to receive direct vaccine protection was demonstrated, suggesting herd effect.en_US
dc.description.sponsorshipGlaxoSmithKline Biologicals SA Landspitali University Hospital Research Funden_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.urlhttps://academic.oup.com/cid/article/67/8/1213/4956759en_US
dc.subjectEyrnabólgaen_US
dc.subjectBólusetningaren_US
dc.subject.meshOtitis Mediaen_US
dc.subject.meshVaccinesen_US
dc.subject.meshHaemophilus Vaccinesen_US
dc.titleReduction in All-Cause Acute Otitis Media in Children <3 Years of Age in Primary Care Following Vaccination With 10-Valent Pneumococcal Haemophilus influenzae Protein-D Conjugate Vaccine: A Whole-Population Study.en_US
dc.typeArticleen_US
dc.contributor.department1 Faculty of Medicine, University of Iceland. 2 Department of Mathematics, University of Iceland. 3 Department of Clinical Microbiology, Reykjavík. 4 Children's Hospital Iceland, Landspítali University Hospital, Reykjavík.en_US
dc.identifier.journalClinical infectious diseasesen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodePED12
dc.departmentcodeBAC12
dc.departmentcodeNAF12
dc.source.journaltitleClinical infectious diseases : an official publication of the Infectious Diseases Society of America


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