Show simple item record

dc.contributor.authorShah, Shailja C
dc.contributor.authorKhalili, Hamed
dc.contributor.authorGower-Rousseau, Corinne
dc.contributor.authorOlen, Ola
dc.contributor.authorBenchimol, Eric I
dc.contributor.authorLynge, Elsebeth
dc.contributor.authorNielsen, Kári R
dc.contributor.authorBrassard, Paul
dc.contributor.authorVutcovici, Maria
dc.contributor.authorBitton, Alain
dc.contributor.authorBernstein, Charles N
dc.contributor.authorLeddin, Desmond
dc.contributor.authorTamim, Hala
dc.contributor.authorStefansson, Tryggvi
dc.contributor.authorLoftus, Edward V
dc.contributor.authorMoum, Bjørn
dc.contributor.authorTang, Whitney
dc.contributor.authorNg, Siew C
dc.contributor.authorGearry, Richard
dc.contributor.authorSincic, Brankica
dc.contributor.authorBell, Sally
dc.contributor.authorSands, Bruce E
dc.contributor.authorLakatos, Peter L
dc.contributor.authorVégh, Zsuzsanna
dc.contributor.authorOtt, Claudia
dc.contributor.authorKaplan, Gilaad G
dc.contributor.authorBurisch, Johan
dc.contributor.authorColombel, Jean-Frederic
dc.date.accessioned2018-11-13T13:41:55Z
dc.date.available2018-11-13T13:41:55Z
dc.date.issued2018-01-01
dc.date.submitted2018-11
dc.identifier.citationSex-Based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-Based Studies From Western Countries. 2018, 155(4):1079-1089.e3 Gastroenterologyen_US
dc.identifier.issn1528-0012
dc.identifier.pmid29958857
dc.identifier.doi10.1053/j.gastro.2018.06.043
dc.identifier.urihttp://hdl.handle.net/2336/620736
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractAlthough the incidence of inflammatory bowel diseases (IBDs) varies with age, few studies have examined variations between the sexes. We therefore used population data from established cohorts to analyze sex differences in IBD incidence according to age at diagnosis. We identified population-based cohorts of patients with IBD for which incidence and age data were available (17 distinct cohorts from 16 regions of Europe, North America, Australia, and New Zealand). We collected data through December 2016 on 95,605 incident cases of Crohn's disease (CD) (42,831 male and 52,774 female) and 112,004 incident cases of ulcerative colitis (UC) (61,672 male and 50,332 female). We pooled incidence rate ratios of CD and UC for the combined cohort and compared differences according to sex using random effects meta-analysis. Female patients had a lower risk of CD during childhood, until the age range of 10-14 years (incidence rate ratio, 0.70; 95% CI, 0.53-0.93), but they had a higher risk of CD thereafter, which was statistically significant for the age groups of 25-29 years and older than 35 years. The incidence of UC did not differ significantly for female vs male patients (except for the age group of 5-9 years) until age 45 years; thereafter, men had a significantly higher incidence of ulcerative colitis than women. In a pooled analysis of population-based studies, we found age at IBD onset to vary with sex. Further studies are needed to investigate mechanisms of sex differences in IBD incidence.en_US
dc.language.isoenen_US
dc.publisherW.B. Saundersen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0016508518346857en_US
dc.subjectEpidemiologyen_US
dc.subjectEstrogenen_US
dc.subjectMenopauseen_US
dc.subjectPubertyen_US
dc.subject.meshInflammatory Bowel Diseasesen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshAge Distributionen_US
dc.titleSex-Based Differences in Incidence of Inflammatory Bowel Diseases-Pooled Analysis of Population-Based Studies From Western Countries.en_US
dc.typeArticleen_US
dc.contributor.department1 Division of Gastroenterology, Mount Sinai Hospital, New York, New York; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: shailja.c.shah@vanderbilt.edu. 2 Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. 3 Public Health Unit, Epimad Registre, Lille University Hospital, France; INSERM LIRIC, UMR 995, Lille University, France. 4 Department of Medicine, Karolinska Institutet, Stockholm, Sweden. 5 CHEO Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada; Department of Pediatrics and School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada. 6 Division of Gastroenterology, University of Copenhagen, Copenhagen, Denmark. 7 Division of Gastroenterology, National Hospital, Tórshavn, Faroe Islands. 8 Department of Medicine, McGill University, Montreal, Quebec, Canada. 9 Department of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada. 10 Division of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada. 11 Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada. 12 Division of Gastroenterology, National University Hospital of Iceland, Reykjavík, Iceland. 13 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, New York. 14 Department of Gastroenterology, Oslo University Hospital and University of Oslo, Oslo, Norway. 15 Department of Medicine and Therapeutics, Institute of Digestive Disease, LKS Institute of Health Science, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong. 16 Division of Gastroenterology, University of Otago, Christchurch, New Zealand. 17 Division of Gastroenterology, University of Rijeka, Rijeka, Croatia. 18 Division of Gastroenterology, St. Vincent's Hospital, Melbourne, Australia. 19 Division of Gastroenterology, Mount Sinai Hospital, New York, New York. 20 Division of Gastroenterology, Semmelweis University, Budapest, Hungary. 21 Division of Gastroenterology, University of Regensburg, Regensburg, Germany. 22 Department of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. 23 Department of Gastroenterology, North Zealand University Hospital, Frederikssund, Denmark.en_US
dc.identifier.journalGastroenterologyen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodeSAM12
dc.source.journaltitleGastroenterology


This item appears in the following Collection(s)

Show simple item record