Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

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Authors
Gudmundsson, Julius
Sigurdsson, Jon K
Stefansdottir, Lilja
Agnarsson, Bjarni A
Isaksson, Helgi J
Stefansson, Olafur A
Gudjonsson, Sigurjon A
Gudbjartsson, Daniel F
Masson, Gisli
Frigge, Michael L
Issue Date
2018-11-08

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Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA. 2018, 9(1):4568 Nat Commun
Abstract
Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P < 0.0022). Furthermore, there is a strong genetic correlation, r
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https://www.nature.com/articles/s41467-018-06920-9
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