Genome-wide association meta-analysis yields 20 loci associated with gallstone disease.
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Authors
Ferkingstad, EgilOddsson, Asmundur
Gretarsdottir, Solveig
Benonisdottir, Stefania
Thorleifsson, Gudmar
Deaton, Aimee M
Jonsson, Stefan
Stefansson, Olafur A
Norddahl, Gudmundur L
Zink, Florian
Arnadottir, Gudny A
Gunnarsson, Bjarni
Halldorsson, Gisli H
Helgadottir, Anna
Jensson, Brynjar O
Kristjansson, Ragnar P
Sveinbjornsson, Gardar
Sverrisson, David A
Masson, Gisli
Olafsson, Isleifur
Eyjolfsson, Gudmundur I
Sigurdardottir, Olof
Holm, Hilma
Jonsdottir, Ingileif
Olafsson, Sigurdur
Steingrimsdottir, Thora
Rafnar, Thorunn
Bjornsson, Einar S
Thorsteinsdottir, Unnur
Gudbjartsson, Daniel F
Sulem, Patrick
Stefansson, Kari
Útgáfudagur
2018-11-30
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Genome-wide association meta-analysis yields 20 loci associated with gallstone disease. 2018, 9(1):5101 Nat CommunÚtdráttur
Gallstones are responsible for one of the most common diseases in the Western world and are commonly treated with cholecystectomy. We perform a meta-analysis of two genome-wide association studies of gallstone disease in Iceland and the UK, totaling 27,174 cases and 736,838 controls, uncovering 21 novel gallstone-associated variants at 20 loci. Two distinct low frequency missense variants in SLC10A2, encoding the apical sodium-dependent bile acid transporter (ASBT), associate with an increased risk of gallstone disease (Pro290Ser: OR = 1.36 [1.25-1.49], P = 2.1 × 10Lu00FDsing
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10.1038/s41467-018-07460-y
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