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dc.contributor.authorStyrkarsdottir, Unnur
dc.contributor.authorLund, Sigrun H
dc.contributor.authorThorleifsson, Gudmar
dc.contributor.authorZink, Florian
dc.contributor.authorStefansson, Olafur A
dc.contributor.authorSigurdsson, Jon K
dc.contributor.authorJuliusson, Kristinn
dc.contributor.authorBjarnadottir, Kristbjörg
dc.contributor.authorSigurbjornsdottir, Sara
dc.contributor.authorJonsson, Stefan
dc.contributor.authorNorland, Kristjan
dc.contributor.authorStefansdottir, Lilja
dc.contributor.authorSigurdsson, Asgeir
dc.contributor.authorSveinbjornsson, Gardar
dc.contributor.authorOddsson, Asmundur
dc.contributor.authorBjornsdottir, Gyda
dc.contributor.authorGudmundsson, Reynir L
dc.contributor.authorHalldorsson, Gisli H
dc.contributor.authorRafnar, Thorunn
dc.contributor.authorJonsdottir, Ingileif
dc.contributor.authorSteingrimsson, Eirikur
dc.contributor.authorNorddahl, Gudmundur L
dc.contributor.authorMasson, Gisli
dc.contributor.authorSulem, Patrick
dc.contributor.authorJonsson, Helgi
dc.contributor.authorIngvarsson, Thorvaldur
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorStefansson, Kari
dc.date.accessioned2019-01-02T11:00:59Z
dc.date.available2019-01-02T11:00:59Z
dc.date.issued2018-12-01
dc.date.submitted2019-01
dc.identifier.citationMeta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. 2018, 50(12):1681-1687 Nat Geneten_US
dc.identifier.issn1546-1718
dc.identifier.pmid30374069
dc.identifier.doi10.1038/s41588-018-0247-0
dc.identifier.urihttp://hdl.handle.net/2336/620774
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractOsteoarthritis has a highly negative impact on quality of life because of the associated pain and loss of joint function. Here we describe the largest meta-analysis so far of osteoarthritis of the hip and the knee in samples from Iceland and the UK Biobank (including 17,151 hip osteoarthritis patients, 23,877 knee osteoarthritis patients, and more than 562,000 controls). We found 23 independent associations at 22 loci in the additive meta-analyses, of which 16 of the loci were novel: 12 for hip and 4 for knee osteoarthritis. Two associations are between rare or low-frequency missense variants and hip osteoarthritis, affecting the genes SMO (rs143083812, frequency 0.11%, odds ratio (OR) = 2.8, P = 7.9 × 10en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.urlhttps://www.nature.com/articles/s41588-018-0247-0en_US
dc.subjectSlitgigten_US
dc.subjectGenen_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.subject.meshOsteoarthritisen_US
dc.titleMeta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.en_US
dc.typeArticleen_US
dc.contributor.department1 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. unnur.styrkarsdottir@decode.is. 2 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. 3 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 4 Biochemistry and Molecular Biology, BioMedical Center, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 5 Department of Immunology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 6 Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland. 7 Department of Orthopedic Surgery, Akureyri Hospital, Akureyri, Iceland. 8 Institution of Health Science, University of Akureyri, Akureyri, Iceland. 9 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 10 deCODE genetics/Amgen, Inc., Reykjavik, Iceland. kstefans@decode.is. 11 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. kstefans@decode.is.en_US
dc.identifier.journalNature geneticsen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodeNAF12
dc.departmentcodeRHE12
dc.source.journaltitleNature genetics


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