NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

Cast your vote
 
Your vote was cast
Thank you for your feedback
Authors
Tulstrup, Morten
Grosjean, Marie
Nielsen, Stine Nygaard
Grell, Kathrine
Wolthers, Benjamin Ole
Wegener, Peder Skov
Jonsson, Olafur Gisli
Lund, Bendik
Harila-Saari, Arja
Abrahamsson, Jonas
Issue Date
2018-12-01

Metadata
Show full item record
Citation
NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia. 2018, 32(12):2527-2535 Leukemia
Abstract
The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (
Description
To access publisher's full text version of this article click on the hyperlink below
Additional Links
https://search.proquest.com/docview/2151748244/F7927333457E477APQ/2?accountid=135775
https://www.nature.com/articles/s41375-018-0245-3
Collections