NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia.

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Authors
Tulstrup, Morten
Grosjean, Marie
Nielsen, Stine Nygaard
Grell, Kathrine
Wolthers, Benjamin Ole
Wegener, Peder Skov
Jonsson, Olafur Gisli
Lund, Bendik
Harila-Saari, Arja
Abrahamsson, Jonas
Vaitkeviciene, Goda
Pruunsild, Kaie
Toft, Nina
Holm, Mette
Hulegårdh, Erik
Liestøl, Sigurd
Griskevicius, Laimonas
Punab, Mari
Wang, Jinhua
Carroll, William L
Zhang, Zeyu
Dalgaard, Marlene D
Gupta, Ramneek
Nersting, Jacob
Schmiegelow, Kjeld
Issue Date
2018-12-01

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Citation
NT5C2 germline variants alter thiopurine metabolism and are associated with acquired NT5C2 relapse mutations in childhood acute lymphoblastic leukaemia. 2018, 32(12):2527-2535 Leukemia
Abstract
The antileukaemic drug 6-mercaptopurine is converted into thioguanine nucleotides (TGN) and incorporated into DNA (DNA-TG), the active end metabolite. In a series of genome-wide association studies, we analysed time-weighted means (
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https://search.proquest.com/docview/2151748244/F7927333457E477APQ/2?accountid=135775
https://www.nature.com/articles/s41375-018-0245-3
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