Early Introduction of Egg and the Development of Egg Allergy in Children: A Systematic Review and Meta-Analysis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
CitationEarly Introduction of Egg and the Development of Egg Allergy in Children: A Systematic Review and Meta-Analysis. 2018, 177(4):350-359 Int Arch Allergy Immunol
AbstractThe timing of the introduction of egg to an infant's diet is of current interest, as new evidence raises questions regarding the benefit of delaying egg introduction. The objective of this study was to systematically review the existing literature regarding the effect of the early introduction of egg on the development of egg allergy. Literature searches were conducted in MEDLINE, EMBASE, and CENTRAL, and trial protocols were searched in Meta Register and OpenGREY. Only randomized controlled trials (RCTs) comparing early (between 3 and 6 months of age) egg introduction to no early introduction were included. The primary outcome was the development of egg allergy. Of the 416 articles identified and screened, 6 RCTs met the eligibility criteria for data extraction. Allergic outcomes were evaluated in a total of 3,032 participants. A low to moderate level of evidence showed a benefit of the early introduction of egg (relative risk, RR 0.60, 95% CI 0.44-0.82, p = 0.002, mild heterogeneity, I2 = 23%). The absolute risk reduction for a population with an incidence of egg allergy of 9.3% was 37 fewer cases (95% CI 17-52) per 1,000 people. Consumption of < 4,000 mg/week of egg protein had a greater preventive effect than a higher dose. This systematic review and meta-analysis showed an association between the early introduction of egg and a lower risk of egg allergy. Furthermore, the nature and dose of egg protein exposure may play a role. These findings should be addressed in the context of primary studies.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
- Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease: A Systematic Review and Meta-analysis.
- Authors: Ierodiakonou D, Garcia-Larsen V, Logan A, Groome A, Cunha S, Chivinge J, Robinson Z, Geoghegan N, Jarrold K, Reeves T, Tagiyeva-Milne N, Nurmatov U, Trivella M, Leonardi-Bee J, Boyle RJ
- Issue date: 2016 Sep 20
- [Timing of food introduction to the infant diet and risk of food allergy: a systematic review and Meta-analysis].
- Authors: Dai NN, Li XY, Wang S, Wang JJ, Gao YJ, Li ZL
- Issue date: 2021 Jul 2
- Prolonged breastfeeding and delayed introduction of whole cow's milk into the diet are factors associated with egg sensitization: A matched case-control study.
- Authors: Bedolla-Barajas M, Morales-Romero J, Gaxiola-Arredondo BY, Alcalá-Padilla G, Romero-Velarde E
- Issue date: 2018 Nov - Dec
- Position document: IgE-mediated allergy to egg protein.
- Authors: Martorell A, Alonso E, Boné J, Echeverría L, López MC, Martín F, Nevot S, Plaza AM, Food Allergy Committee of SEICAP.
- Issue date: 2013 Sep-Oct
- Early regular egg exposure in infants with eczema: A randomized controlled trial.
- Authors: Palmer DJ, Metcalfe J, Makrides M, Gold MS, Quinn P, West CE, Loh R, Prescott SL
- Issue date: 2013 Aug