Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2019-01-01
Metadata
Show full item recordCitation
Neuropathological investigation of cell layer thickness and myelination in the hippocampus of people with obstructive sleep apnea. 2019, 42(1). doi: 10.1093/sleep/zsy199 SleepAbstract
Obstructive sleep apnea (OSA) is commonly associated with memory impairments. Although MRI studies have found volumetric differences in the hippocampus of people with OSA compared with controls, MRI lacks the spatial resolution to detect changes in the specific regions of the hippocampus that process different types of memory. The present study performed histopathological investigations on autopsy brain tissue from 32 people with OSA (17 females and 15 males) to examine whether the thickness and myelination of the hippocampus and entorhinal cortex (EC) vary as a function of OSA severity. Increasing OSA severity was found to be related to cortical thinning in the molecular layer of the dentate gyrus (r2 = 0.136, p = 0.038), the CA1 (overall, r2 = 0.135, p = 0.039; layer 1, r2 = 0.157, p = 0.025; layer 2, r2 = 0.255, p = 0.003; and layer 3, r2 = 0.185, p = 0.014) and in some layers of the EC (layer 1, r2 = 0.186, p = 0.028; trend in layer 3, r2 = 0.124, p = 0.078). OSA severity was also related to decreased myelin in the deep layers but not the superficial layers of the EC (layer 6, r2 = 0.282, p = 0.006; deep white matter, r2 = 0.390, p = 0.001). Patients known to have used continuous positive airway pressure (CPAP) treatment showed no significant reductions in cortical thickness when compared with controls, suggesting that CPAP had a protective effect. However, CPAP did not protect against myelin loss. The regions of decreased cortical thickness and demyelination are locations of synaptic connections in both the polysynaptic (episodic and spatial) and direct (semantic) memory pathways and may underpin the impairments observed in episodic, semantic, and spatial memory in people with OSA.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://academic.oup.com/sleep/article/42/1/zsy199/5139668ae974a485f413a2113503eed53cd6c53
10.1093/sleep/zsy199
Scopus Count
Collections
Related articles
- Obstructive sleep apnea and cortical thickness in females and males.
- Authors: Macey PM, Haris N, Kumar R, Thomas MA, Woo MA, Harper RM
- Issue date: 2018
- Volumetric brain magnetic resonance imaging analysis in children with obstructive sleep apnea.
- Authors: Musso MF, Lindsey HM, Wilde EA, Hunter JV, Glaze DG, Goodrich-Hunsaker NJ, Wu TC, Black G, Biekman B, Zhang W, Zhu H, Anand GS, Friedman EM
- Issue date: 2020 Nov
- Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness.
- Authors: Xiong Y, Zhou XJ, Nisi RA, Martin KR, Karaman MM, Cai K, Weaver TE
- Issue date: 2017 May
- Association of Obstructive Sleep Apnea with Episodic Memory and Cerebral Microvascular Pathology: A Preliminary Study.
- Authors: Kerner NA, Roose SP, Pelton GH, Ciarleglio A, Scodes J, Lentz C, Sneed JR, Devanand DP
- Issue date: 2017 Mar
- Obstructive Sleep Apnea is Associated With Early but Possibly Modifiable Alzheimer's Disease Biomarkers Changes.
- Authors: Liguori C, Mercuri NB, Izzi F, Romigi A, Cordella A, Sancesario G, Placidi F
- Issue date: 2017 May 1